Overexpression of S100A13 protein is associated with tumor angiogenesis and poor survival in patients with early‐stage non‐small cell lung cancer

Abstract

BackgroundS100A13 plays a key role in tumor growth and metastasis. The purpose of this study was to investigate the prognostic significance of S100A13 expression, microvessel density (MVD), and survival in early stage non‐small cell lung cancer (NSCLC).MethodsIn silico analysis was performed to determine the associations between S100A13 and NSCLC. The data of 82 patients with early‐stage NSCLC who underwent radical resection were evaluated. Paraffin‐embedded tumor specimens were stained with S100A13 and CD31 (a specific endothelial marker) using immunohistochemical methods. Prognostic significance was assessed by univariate and multivariate analyses.ResultsS100A13 messenger RNA was overexpressed in NSCLC, especially in advanced stage. Of the 82 NSCLC specimens examined, 37 (45.1%) cases exhibited S100A13 overexpression and 31 (37.8%) showed high MVD. Univariate analysis indicated that gender, age, smoking status, histology type, tumor differentiation, and T stage were not significantly associated with prognosis. However, the overall and disease‐free survival rates of patients with S100A13 overexpression and high MVD were significantly lower than in the remaining cases. Multivariate analysis demonstrated that only S100A13 overexpression was an independent factor for poor prognosis in early‐stage NSCLC. Statistical analysis demonstrated that the MVD was significantly higher in tumors with high (67.6%, 25/37) compared to low S100A13 expression (13.3%, 6/45) (P < 0.01).ConclusionsHigh S100A13 expression is closely associated with high intratumoral angiogenesis and poor prognosis in patients with stage I NSCLC. Immunohistochemical evaluation of S100A13 expression, along with an examination of the perioperative extent of angiolymphatic invasion, has value for predicting prognosis.

The design and development of covalent protein-protein interaction inhibitors for cancer treatment

“…The cancer-related proteins are abnormally expressed (overexpressed, low expressed, or mutant) in cancer cells compared to normal cells. For example, S100A13 overexpression contributed to tumor metastasis and poor survival in patients with early-stage non-small cell lung cancer [16]. Low TMEFF2 expression was associated with larger tumor size and advanced stage and poor differentiation in pancreatic cancer cells [17].…”

Development of a prognostic model based on an immunogenomic landscape analysis of medulloblastoma

“…And the transcellular neutrophil diapedesis across the blood-brain barrier is dependent on endothelial ICAM2 48 . S100 Calcium Binding Protein A13 (S100A13) is an acidic-Ca2+ binding protein of the S100 family, which has been proved to be a powerfully angiogenic biomarker for several tumors [49][50][51] .…”

Identification of lung adenocarcinoma biomarkers based on bioinformatic analysis and human samples

“…The downregulated genes were mainly overrepresented in cell division, nuclear division, DNA replication and second-messenger-mediated signaling, and the upregulated genes were mainly involved in cell cycle process, DNA metabolic process, the transforming growth factor (TGF)-β signaling pathway and angiogenesis. Previous articles have revealed that dysregulation of angiogenesis and activation of the TGF-β signaling pathway are associated with the carcinogenesis and progression of lung adenocarcinoma (36)(37)(38). In addition, DNA damage and metabolic process abnormalities often play a significant role in cell cycle regulation dysfunction and are associated with malignant tumors (39).…”