Overexpression of the cancer stem cell marker CD117 predicts poor prognosis in epithelial ovarian cancer patients: evidence from meta-analysis

Abstract

05-3.26). EOC patients with high CD117 expression had significantly worse OS (hazard ratio [HR] =1.39, 95% CI =1.03-1.90) than patients with low CD117 expression. However, no significant correlation was found between CD117 expression and disease-free survival (HR =1.31, 95% CI =0.79-2.17). In subgroup analysis, CD117 was identified as a significant prognostic factor for overall survival in European patients (HR =1.59, 95% CI =1.13-2.23), younger patients (,60 years) (HR =1.59, 95% CI =1.10-2.30), studies with sample sizes 200 (HR =1.84, 95% CI =1.32-2.56), and the mixed histological types (HR =1.47; 95% CI =1.08-2.00). Conclusion: Our meta-analysis suggests that CD117 is associated with EOC progression and can serve as a promising prognostic predictor for EOC patients. However, larger scale multicenter clinical trials are still needed to further validate our results.

Stable expansion of high‐grade serous ovarian cancer organoids requires a low‐Wnt environment

“…The high degree of consistency in MYCN regulation in KD FT and HGSOC organoids from independent donor samples warrants further studies to investigate its potential role as a stemness marker in HGSOC. Also, while we show that surface expression of CD133 correlates with in vitro growth capacity of HGSOC organoids, the exact functional relationship between stemness regulation in the organoid culture and other previously described ovarian cancer stem cell markers CD117, ALDH1 and CD24 (Gao et al, 2010;Kryczek et al, 2012;Yang et al, 2017a) is yet to be tested.…”

Ovarian Cancers: Genetic Abnormalities, Tumor Heterogeneity and Progression, Clonal Evolution and Cancer Stem Cells

“…CD117 + /CD44 + cells isolated from the ascitic fluid of ovarian cancer patients are very sensitive to the anti-cancer stem cell antibiotic salinomycin: this drug added alone induced an inhibition of stemness markers of CD117 + /CD44 + cells, such as SOX2 and OCT 3-4 and added together with paclitaxel induced apoptosis of these cells [ 244 ]. About 25% of HGS-OvCa patients display overexpression of CD117; a meta-analysis on more than 1200 patients reported in literature clearly showed that CD117 overexpression was associated with reduced overall survival [ 245 ].…”

Surface markers of cancer stem-like cells of ovarian cancer and their clinical relevance

“…A meta-analysis of selected CD117 studies showed the relation between CD117 status and several clinical parameters including: age, FIGO stage, tumor grade, histological type. High CD117 expression meant worse OS but no correlation with DFS was found [ 66 ].…”