2007
DOI: 10.1136/jcp.2006.041004
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Overexpression of the obesity hormone leptin in human colorectal cancer

Abstract: Results indicate that leptin is overexpressed in human colorectal cancer, which suggests that the hormone might contribute to colorectal cancer development and progression.

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Cited by 102 publications
(109 citation statements)
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“…Recent reports show that leptin is overexpressed in various cancer cells and plays a role in the development and/or progression of variety of malignancies including colon, gastric, endometrial, and breast cancers (Hu et al 2002, Ishikawa et al 2004, Hong et al 2006, Koda et al 2007a. These findings were further supported by experimental evidence that leptin can stimulate growth and prevent apoptosis in different cellular cancer models (Garofalo & Surmacz 2006, Hoda et al 2007, Ogunwobi & Beales 2007.…”
Section: Discussionsupporting
confidence: 69%
“…Recent reports show that leptin is overexpressed in various cancer cells and plays a role in the development and/or progression of variety of malignancies including colon, gastric, endometrial, and breast cancers (Hu et al 2002, Ishikawa et al 2004, Hong et al 2006, Koda et al 2007a. These findings were further supported by experimental evidence that leptin can stimulate growth and prevent apoptosis in different cellular cancer models (Garofalo & Surmacz 2006, Hoda et al 2007, Ogunwobi & Beales 2007.…”
Section: Discussionsupporting
confidence: 69%
“…In contrast, Stattin et al suggested that leptin is simply an innocent bystander, serving merely as a correlate of other obesity-induced adverse alterations in metabolism that may be the true cause of CRC (16). In human CRC tissue, but not in normal mucosa or adenomas, leptin and its receptor are overexpressed, which correlates with the expression of the proneoplastic transcriptional regulator, hypoxia-inducible factor 1, and a more advanced tumor phenotype (21,22). Moreover, leptin is gradually expressed in the progression of normal cells to adenomas and subsequently to carcinomas, suggesting that leptin may be involved in multistep colorectal carcinogenesis (3).…”
Section: Discussionmentioning
confidence: 99%
“…Besides this migratory activity, another type of locomotion was inducible by physiological extracellular ligands such as the neurotransmitter norepinephrine. In obese individuals, serum levels of leptin are markedly increased, and a recent study indicates that leptin is overexpressed in human colorectal cancer, which suggests that the hormone might contribute to colorectal cancer development and progression (Koda et al 2007). Therefore, we have Figure 4 Role of PKCa and PKCd in the migration of SW480 colon carcinoma cells.…”
Section: Discussionmentioning
confidence: 99%