2011
DOI: 10.1002/jso.21809
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Overexpression of the orphan receptor Nur77 and its translocation induced by PCH4 may inhibit malignant glioma cell growth and induce cell apoptosis

Abstract: In conclusion, PCH4, a derivative of BP, induced Nur77-mediated apoptosis via the JNK pathway and this mechanism, which is different from that of BP, may explain the increase in the anti-tumor effects on GBM.

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Cited by 39 publications
(31 citation statements)
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“…Since it is well established that certain genes/proteins listed in Table 2 can exert different roles according to the cellular context [1] [110] [162] (see file S2 for more details), we also tried to avoid considering functional results obtained from excessive pathological stimuli, which could alter the physiological native role of a gene/protein. For instance in [60] the neurons were treated with Camptothecin to cause DNA damage and the Cbp/p300-interacting transactivator 2 , also known as Cited2 , was related to the activation of apoptosis: we found these circumstances too dissimilar from the gabazine-treatment of the present work and therefore we decided not to consider this as a functional evidence.…”
Section: Resultsmentioning
confidence: 99%
“…Since it is well established that certain genes/proteins listed in Table 2 can exert different roles according to the cellular context [1] [110] [162] (see file S2 for more details), we also tried to avoid considering functional results obtained from excessive pathological stimuli, which could alter the physiological native role of a gene/protein. For instance in [60] the neurons were treated with Camptothecin to cause DNA damage and the Cbp/p300-interacting transactivator 2 , also known as Cited2 , was related to the activation of apoptosis: we found these circumstances too dissimilar from the gabazine-treatment of the present work and therefore we decided not to consider this as a functional evidence.…”
Section: Resultsmentioning
confidence: 99%
“…Several drugs already in clinical use are now recognized to induce nuclear export of NR4A1, including 5-fluorouracil (5-FU) and certain NSAIDs (15). Novel drugs targeting nuclear export of NR4A1 include n-butylenephthalide (BP) and cytosporone B. BP and its derivatives (PCH4) have shown therapeutic potential in glioblastoma multiforme, in vitro and in vivo, and in oral squamous cell carcinoma in vitro (32). PCH4 induces apoptosis in oral squamous cell carcinoma and glioblastoma multiforme cell lines in a mechanism dependent on PCH4-mediated increased NR4A1 expression and cytoplasmic translocation (32,33).…”
Section: Nr4a Receptors: Identified Roles In Human Cancermentioning
confidence: 99%
“…Novel drugs targeting nuclear export of NR4A1 include n-butylenephthalide (BP) and cytosporone B. BP and its derivatives (PCH4) have shown therapeutic potential in glioblastoma multiforme, in vitro and in vivo, and in oral squamous cell carcinoma in vitro (32). PCH4 induces apoptosis in oral squamous cell carcinoma and glioblastoma multiforme cell lines in a mechanism dependent on PCH4-mediated increased NR4A1 expression and cytoplasmic translocation (32,33). Cytosporone B, a compound isolated from fungi, is a ligand for NR4A1 and induces apoptosis by transactivation of NR4A1 target genes and by inducing expression and mitochondrial localization of NR4A1 in vivo and in vitro (34).…”
Section: Nr4a Receptors: Identified Roles In Human Cancermentioning
confidence: 99%
“…The natural compound n-butylidenephthalide (BP), isolated from the chloroform extract of Angelica sinensis, has been reported to have antitumor activity in glioblastoma multiforme (GBM), [1][2][3][4] prostate cancer, 5,6 oral squamous cell carcinoma, 7 lung cancer, 8 and hepatoma. 9 In particular, BP has been developed to treat brain tumors due to its ability to permeate through the blood-brain barrier and enter into the brain.…”
Section: Introductionmentioning
confidence: 99%
“…1 BP induces Nur77-mediated apoptosis via the protein kinase C/JNK pathway. 4,7,9,10 BP downregulates the expression of S-phase kinase-associated protein (Skp2), which leads to an increase in p16 and p21 expression, causing G 0 /G 1 arrest. 2 BP inhibits telomerase activity by repressing hTERT transcriptional activity via the downregulation of Sp1 or AP-2 expression.…”
Section: Introductionmentioning
confidence: 99%