Overexpression of the peripheral benzodiazepine receptor is a relevant prognostic factor in stage III colorectal cancer

Grabowski, Patricia; Maaser, Kerstin; Schindler, Isabell; Foss, Hans‐Dieter; Stein, H; Carayon, Pierre; Gavish, Moshe; Riecken, Ernts-Otto; Zeitz, Martin; Scheruebl, Hans

doi:10.1016/s0016-5085(08)80171-0

Cited by 1 publication

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“…In order to provide information concerning the inflammatory processes in IBD, 18 F-FDG PET imaging has been used in preclinical studies [25, 61, 62] and clinical studies [61, 63–67], especially in pediatric populations [64, 65, 68], and exhibited good diagnostic performances in patients with suspected IBD [58, 69]. Despite the well-known TSPO overexpression in colon cancer [70] and the knowledge that TSPO regulates the growth of colorectal cancer cells [71] which is also an unfavorable prognostic factor in stage III colorectal cancer [72], the involvement of TSPO in IBDs and dysplasia has not yet been completely investigated. After 7 days of treatment by dextran sodium sulfate (DSS), in a way to induce IBD in a rat model, Ostuni and colleagues [73] reported a TSPO overexpression, assessed by immunohistochemistry, in the rat colon of treated animals.…”

Section: Tspo Pet Imaging Of Psidsmentioning

confidence: 99%

TSPO PET Imaging: From Microglial Activation to Peripheral Sterile Inflammatory Diseases?

Largeau

Dupont

Guilloteau

et al. 2017

Contrast Media & Molecular Imaging

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Peripheral sterile inflammatory diseases (PSIDs) are a heterogeneous group of disorders that gathers several chronic insults involving the cardiovascular, respiratory, gastrointestinal, or musculoskeletal system and wherein inflammation is the cornerstone of the pathophysiology. In PSID, timely characterization and localization of inflammatory foci are crucial for an adequate care for patients. In brain diseases, in vivo positron emission tomography (PET) exploration of inflammation has matured over the last 20 years, through the development of radiopharmaceuticals targeting the translocator protein-18 kDa (TSPO) as molecular biomarkers of activated microglia. Recently, TSPO has been introduced as a possible molecular target for PSIDs PET imaging, making this protein a potential biomarker to address disease heterogeneity, to assist in patient stratification, and to contribute to predicting treatment response. In this review, we summarized the major research advances recently made in the field of TSPO PET imaging in PSIDs. Promising preliminary results have been reported in bowel, cardiovascular, and rheumatic inflammatory diseases, consolidated by preclinical studies. Limitations of TSPO PET imaging in PSIDs, regarding both its large expression in healthy peripheral tissues, unlike in central nervous system, and the production of peripheral radiolabeled metabolites, are also discussed, regarding their possible consequences on TSPO PET signal's quantification.

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