Overexpression of the stathmin gene in a subset of human breast cancer

Bièche, Ivan; Lachkar, Sylvie; Becette, Véronique; Cifuentes‐Diaz, Carmen; Sobel, A; Lidereau, Rosette; Curmi, Patrick A.

doi:10.1038/bjc.1998.565

Cited by 91 publications

(89 citation statements)

References 51 publications

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“…These results suggested that the expression of stathmin could contribute to cancer progression/prognosis, and that stathmin may have potential as a biomarker and a therapeutic target for OSCC. These results were in accordance with the high level of stathmin expression in many types of cancer, including leukemia and lymphoma, 65 prostate carcinoma, 66 ovarian carcinoma, 67 Wilms tumor, 68 breast carcinoma, 69 and adenoid cystic carcinoma of the salivary glands. 70 To identify potential biomarkers for laryngeal SCC, Sewell et al compared the protein profile of laryngeal cancer tissue with normal mucosal samples using 2D gel electrophoresis and MS. 44 The differentially expressed proteins were stratifin, S100 calcium-binding protein A9, p21-ARC, stathmin, and enolase.…”

Section: Tissue Biomarker Studiessupporting

confidence: 71%

Head and neck cancer

Rezende

Freire

Franco

2010

Cancer

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Tumors of the head and neck comprise an important neoplasia group, the incidence of which is increasing in many parts of the world. Recent advances in diagnostic and therapeutic techniques for these lesions have yielded novel molecular targets, uncovered signal pathway dominance, and advanced early cancer detection. Proteomics is a powerful tool for investigating the distribution of proteins and small molecules within biological systems through the analysis of different types of samples. The proteomic profiles of different types of cancer have been studied, and this has provided remarkable advances in cancer understanding. This review covers recent advances for head and neck cancer; it encompasses the risk factors, pathogenesis, proteomic tools that can help in understanding cancer, and new proteomic findings in this type of cancer. Cancer 2010;116:4914-25.

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Section: Tissue Biomarker Studiessupporting

confidence: 71%

Head and neck cancer

Rezende

Freire

Franco

2010

Cancer

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“…It is a critical regulator of microtubule dynamics during cell cycle progression and governs preferential microtubule growth around chromosomes during spindle assembly (48). Stathmin is expressed at elevated levels in various human tumors (49,50), and it is expressed at higher levels in proliferating cells as compared with non-proliferating cells (51). The Stathmin promoter contains three E2F-binding sites (47), and a recent study indicates that Stathmin levels are regulated by E2F (33).…”

Section: Discussionmentioning

confidence: 99%

E2F Mediates Sustained G2 Arrest and Down-regulation of Stathmin and AIM-1 Expression in Response to Genotoxic Stress

Polager

Ginsberg

2003

Journal of Biological Chemistry

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Exposure of cells to genotoxic agents results in activation of checkpoint pathways leading to cell cycle arrest. These arrest pathways allow repair of damaged DNA before its replication and segregation, thus preventing accumulation of mutations. The tumor suppressor retinoblastoma (RB) is required for the G 1 /S checkpoint function. In addition, regulation of the G 2 checkpoint by the tumor suppressor p53 is RB-dependent. However, the molecular mechanism underlying the involvement of RB and its related proteins p107 and p130 in the G 2 checkpoint is not fully understood. We show here that sustained G 2 /M arrest induced by the genotoxic agent doxorubicin is E2F-dependent and involves a decrease in expression of two mitotic regulators, Stathmin and AIM-1. Abrogation of E2F function by dominant negative E2F abolishes the doxorubicin-induced down-regulation of Stathmin and AIM-1 and leads to premature exit from G 2 . Expression of the E7 papilloma virus protein, which dissociates complexes containing E2F and RB family members, also prevents the down-regulation of these mitotic genes and leads to premature exit from G 2 after genotoxic stress. Furthermore, genotoxic stress increases the levels of nuclear E2F-4 and p130 as well as their in vivo binding to the Stathmin promoter. Thus, functional complexes containing E2F and RB family members appear to be essential for repressing expression of critical mitotic regulators and maintaining the G 2 /M checkpoint.

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“…54,55 Stathmin is expressed at high levels in a wide variety of human malignancies. [56][57][58][59] We identified overexpression of stathmin in ACC tissue. Further, we detected stathmin protein expression in 2 cases with NSG, 10 cases of PA and 10 cases of ACC using immunohistochemistry (Fig.…”

Section: Figurementioning

confidence: 99%

Protein expression profiling identifies maspin and stathmin as potential biomarkers of adenoid cystic carcinoma of the salivary glands

Nakashima

Uzawa

Kasamatsu

et al. 2005

Intl Journal of Cancer

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Adenoid cystic carcinoma (ACC) is one of the most common malignant tumors of the salivary glands. It tends to grow slowly but is associated with a poor prognosis compared to other malignant salivary gland tumors. To identify specific markers of ACC, we examined protein expression profiling in ACC xenograft and normal salivary glands (NSG) using fluorescent 2-dimensional differential in-gel electrophoresis (2-D-DIGE), an emerging technique for comparative proteomics, that improves the reproducibility and reliability of differential protein expression analysis between the samples. To identify the proteins, matrix-assisted laser desorption/ionization time-of-flight peptide mass fingerprinting was carried out. Using these strategies, we detected 4 upregulated proteins and 5 downregulated proteins in ACC xenograft. Maspin and stathmin were selected for further analyses. Western blotting and immunohistochemical staining showed a higher expression of these proteins in ACC xenograft and clinical ACC tissue compared to NSG. Furthermore, Expression of these proteins was correlated with the histologic grading of ACC (n 5 10). Therefore, our data indicate that maspin and stathmin may be not only useful biomarkers of ACC but also markers of biologic behavior in this tumor. ' 2005 Wiley-Liss, Inc.

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Overexpression of the stathmin gene in a subset of human breast cancer

Cited by 91 publications

References 51 publications

Head and neck cancer

Head and neck cancer

E2F Mediates Sustained G2 Arrest and Down-regulation of Stathmin and AIM-1 Expression in Response to Genotoxic Stress

Protein expression profiling identifies maspin and stathmin as potential biomarkers of adenoid cystic carcinoma of the salivary glands

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