Overexpression of TRIM44 is an independent marker for predicting poor prognosis in epithelial ovarian cancer

Liu, Shuang; Yin, Hexuan; Ji, Hongying; Zhu, Jiaqi; Ma, Rong

doi:10.3892/etm.2018.6541

Cited by 22 publications

(24 citation statements)

References 12 publications

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“…To elucidate the underlying mechanism of miR-192-5p involved in cell biological function in lung cancer, the TargetScan and miRNA databases were used to identify that miR-192-5p may combine with TRIM44. TRIM44 has been reported to be upregulated in many types of tumours, and TRIM44 is involved in tumour formation and progression 27,32,33 . Accumulating evidence has revealed that TRIM44 enhances the proliferation, migration, and invasion of lung cancer.…”

Section: Discussionmentioning

confidence: 99%

miR-192-5p suppresses the progression of lung cancer bone metastasis by targeting TRIM44

Zou

Zhu

Lian

et al. 2019

Sci Rep

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Lung cancer is the leading cause of cancer-related deaths worldwide, with 50-70% of patients suffering from bone metastasis. Accumulating evidence has demonstrated that miRNAs are involved in cell proliferation, migration, and invasion in malignancy, such as lung cancer bone metastasis. In the present study, we demonstrated that reduced miR-192-5p and increased TRIM44 levels were associated with the proliferation, migration and invasion of lung cancer. Furthermore, the potential functions of miR-192-5p were explored in A549 and NCI-H1299 cells. We found that miR-192-5p upregulation suppressed tumour behaviours in lung cancer cells. To further investigate whether miR-192-5p is associated with TRIM44, we used TargetScan software to predict the binding site between miR-192-5p and TRIM44. Luciferase activity assays were performed to verify this prediction. In addition, the significant role of miR-192-5p in negatively regulating TRIM44 expression was manifested by our research group. our results suggest that miR-192-5p inhibited the proliferation, migration and invasion of lung cancer through TRIM44.

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Section: Discussionmentioning

confidence: 99%

miR-192-5p suppresses the progression of lung cancer bone metastasis by targeting TRIM44

Zou

Zhu

Lian

et al. 2019

Sci Rep

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“…Over the past decades, efforts have been made to identify accurate biomarkers for gynecological cancer. For instance, upregulation of TRIM44 predicts poor prognosis in epithelial ovarian cancer (25), and LYL1 amplification predicts a shorter survival time of patients with UCEC (26). However, the prognosis of patients with gynecological cancer remains poor.…”

Section: Discussionmentioning

confidence: 99%

Identification of hub genes and key pathways associated with the progression of gynecological cancer

Zhang

Wang

2019

Oncol Lett

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Gynecological cancer is the leading cause of cancer mortality in women. However, the mechanisms underlying gynecological cancer progression have remained largely unclear. In the present study, 799 dysregulated genes were identified in ovarian serous cystadenocarcinoma (OV), 488 dysregulated genes in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), and 621 dysregulated genes in uterine corpus endometrial carcinoma (UCEC). Bioinformatics analysis revealed that mRNA splicing and cell proliferation-associated biological processes served important roles in OV progression. Metabolism-associated biological processes played important roles in CESC progression, and protein phosphorylation and small GTPase-mediated signal transduction served important roles in UCEC progression. The present study also constructed OV, CESC and UCEC progression-associated protein-protein interaction networks to reveal the associations among these genes. Furthermore, Kaplan-Meier curve analysis showed that progression-related genes were associated with the duration of overall survival. Finally, NARS2 and TPT1 in OV, SMYD2, EGLN1, TNFRSF10D, FUT11, SYTL3, MMP8 and EREG in CESC, and SLC5A1, TXN, KDM4B, TXNDC11, HSDL2, COX16, MGAT4A, DAGLA, ELOVL7, THRB and PCOLCE2 in UCEC were identified as hub genes in cancer progression. Therefore, this study may assist in the identification of novel mechanisms underlying cancer progression and new biomarkers for gynecological cancer prognosis and therapy.

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“…From a clinicopathological point of view, we previously showed that TRIM44 overexpression was associated with poor prognosis in testicular germ cell tumors . Other studies include an immunohistochemical (IHC) analysis that demonstrated that overexpression of TRIM44 was an independent predictor of poor prognosis in a series of 109 patients with epithelial ovarian cancer . Another IHC study revealed that TRIM44 overexpression was significantly associated with histological grade, depth of myometrial invasion and lymph node metastasis in endometrial carcinoma .…”

Section: Discussionmentioning

confidence: 99%

“…22 Other studies include an immunohistochemical (IHC) analysis that demonstrated that overexpression of TRIM44 was an independent predictor of poor prognosis in a series of 109 patients with epithelial ovarian cancer. 47 Another IHC study revealed that TRIM44 overexpression was significantly associated with histological grade, depth of myometrial invasion and lymph node metastasis in endometrial carcinoma. 48 In esophageal squamous cell carcinoma, overexpression of TRIM44 was associated with the status of lymph node metastasis and poor overall survival.…”

Section: Discussionmentioning

confidence: 99%

TRIM44 promotes cell proliferation and migration by inhibiting FRK in renal cell carcinoma

et al. 2020

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TRIM44 has oncogenic roles in various cancers. However, TRIM44 expression and its function in renal cell carcinoma (RCC) are still unknown. Here in this study, we investigated the clinical significance of TRIM44 and its biological function in RCC. TRIM44 overexpression was significantly associated with clinical M stage, histologic type (clear cell) and presence of lymphatic invasion (P = .047, P = .005, and P = .028, respectively). Moreover, TRIM44 overexpression was significantly associated with poor prognosis in terms of cancer‐specific survival (P = .019). Gain‐of‐function and loss‐of‐function studies using TRIM44 and siTRIM44 transfection showed that TRIM44 promotes cell proliferation and cell migration in two RCC cell lines, Caki1 and 769P. To further investigate the role of TRIM44 in RCC, we performed integrated microarray analysis in Caki1 and 769P cells and explored the data in the Oncomine database. Interestingly, FRK was identified as a promising candidate target gene of TRIM44, which was downregulated in RCC compared with normal renal tissues. We found that cell proliferation was inhibited by TRIM44 knockdown and then recovered by siFRK treatment. Taken together, the present study revealed the association between high expression of TRIM44 and poor prognosis in RCC patients and that TRIM44 promotes cell proliferation by regulating FRK.

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Overexpression of TRIM44 is an independent marker for predicting poor prognosis in epithelial ovarian cancer

Cited by 22 publications

References 12 publications

miR-192-5p suppresses the progression of lung cancer bone metastasis by targeting TRIM44

miR-192-5p suppresses the progression of lung cancer bone metastasis by targeting TRIM44

Identification of hub genes and key pathways associated with the progression of gynecological cancer

TRIM44 promotes cell proliferation and migration by inhibiting FRK in renal cell carcinoma

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