Overlap syndromes with sarcoidosis

James, David G.; Sharma, Om P.

doi:10.1136/pgmj.61.719.769

Cited by 25 publications

(11 citation statements)

References 19 publications

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“…Sarcoidosis mainly involves the lungs, even though other organs may be involved. Moreover, sarcoidosis has been associated with different autoimmune disorders, such as primary biliary cirrhosis, Crohn's disease, and Sjogren's syndrome [1].…”

mentioning

confidence: 99%

Sarcoidosis and coeliac disease: do not forget the association!

et al. 2011

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mentioning

confidence: 99%

Sarcoidosis and coeliac disease: do not forget the association!

et al. 2011

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“…The incidence of sarcoidosis is 1·0–35·5 in 100 000/year 2. It can be difficult to differentiate from other diagnoses as the presenting symptoms and features overlap extensively with other diseases 3 4. Sarcoidosis presents with non-specific symptoms including fever, fatigue and weight loss, as well as specific symptoms related to the organ involved 5.…”

Section: Discussionmentioning

confidence: 99%

Is this still just sarcoidosis, or should we a-DRESS a different diagnosis?

et al. 2015

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An Afro-Caribbean woman presented with worsening breathlessness, weight loss, lethargy and fevers, developing a bilateral florid erythematous rash on her legs. She was recently diagnosed with rheumatoid arthritis and bilateral hilar lymphadenopathy was found on thoracic CT imaging. She was tachycardic and investigations revealed pancytopenia, eosinophilia, raised serum ACE, acute kidney injury and deranged liver function tests. Biopsy of the lymphadenopathy revealed mixed lymphoid cells and liver biopsy revealed extramedullary haematopoiesis, with hypercellular marrow found on bone marrow biopsy. Cardiac MRI was normal, excluding cardiac sarcoid. The patient developed status epilepticus and phenytoin was started. She subsequently developed skin desquamation, in keeping with toxic epidermal necrosis. Skin biopsies revealed atypical granulomas and multinucleated giant cells, which subsequently resolved on steroid treatment. This case highlights an overlap syndrome, with an unclear diagnosis between sarcoidosis, drug reaction or rash with eosinophilia and systemic symptoms and/or hypereosinophilic syndrome and Still's disease. Hence varied serological and clinical features can complicate the distinction between diagnoses.

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“…Entre los años 1950 y 1953 se realizaron 52 371 autopsias en el hospital universitario de la Universidad de California en Los Ángeles (UCLA), se registraron 503 casos de amiloidosis y 116 casos de sarcoidosis; en siete de las autopsias se encontraron de forma concomitante ambas entidades (5). A continuación, presentamos el caso de un paciente en el que documentamos ambas enfermedades de forma concomitante.…”

Section: Médico Generalunclassified