Overlapping tumor‐specific expression of p53, p16<sup>INK4a</sup>, and sirtuin 1 in Bowen's disease: A case report

Takada, Toru

doi:10.1002/ccr3.3400

Clinical Case Reports

2020

DOI: 10.1002/ccr3.3400

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Overlapping tumor‐specific expression of p53, p16^INK4a, and sirtuin 1 in Bowen's disease: A case report

Toru Takada¹

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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2023

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Current Views on the Pathogenesis and Early Diagnosis of Actinic Keratosis

A.A.,

G.B.,

O.G.

2023

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The article provides an overview of the epidemiology and pathogenesis of actinic keratosis (AK) and its clinical differentiation from cutaneous squamous cell carcinoma (SCC). The authors present varying perspectives on the prognosis of the disease's development and its pathogenetic link to SCC, highlighting the significance of early diagnosis of the malignant transformation. Researchers suggest several markers, such as p16, p53, and p63, to identify the malignant transition in its early stages. The authors support their hypothesis by offering that mutations in genes that express these proteins directly impact the progression of the disease. Another group of authors, recognizing the significant role of inflammation in the pathogenesis of AK, suggest determining the level of various cytokines, emphasizing the essential role of UV radiation in triggering the entire pathogenetic cascade of AK development. Meanwhile, most authors acknowledge that various proteins act as early immunohistochemical (IHC) markers of an unfavorable disease prognosis. They describe the pathogenetic mechanisms of the effect of markers such as p16, p53, p63, and Bcl-2. Research is underway to identify new markers, such as claudin and T-cadherin. In August 2023, a search was conducted on the PubMed Clinical Queries database using keywords such as "actinic keratosis", "pathogenesis of actinic keratosis", and "progression of actinic keratosis to squamous cell carcinoma" to look for early markers of malignancy. The search strategy included clinical trials, observational studies, case reports, and literature reviews published in the last decade. However, sources without peer review, such as educational and methodological guidelines, recommendations, and conference proceedings, were excluded. The information obtained through this search was used to compile this article, and promising directions for the search for early malignancy markers were identified. Keywords: Actinic keratosis, pathogenesis, clinical forms, early diagnostic markers, progression, squamous cell carcinoma, precancerous skin diseases.

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Current Views on the Pathogenesis and Early Diagnosis of Actinic Keratosis

A.A.,

G.B.,

O.G.

2023

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Overlapping tumor‐specific expression of p53, p16^INK4a, and sirtuin 1 in Bowen's disease: A case report

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 1 publication

References 25 publications

Current Views on the Pathogenesis and Early Diagnosis of Actinic Keratosis

Current Views on the Pathogenesis and Early Diagnosis of Actinic Keratosis

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Overlapping tumor‐specific expression of p53, p16INK4a, and sirtuin 1 in Bowen's disease: A case report

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 1 publication

References 25 publications

Current Views on the Pathogenesis and Early Diagnosis of Actinic Keratosis

Current Views on the Pathogenesis and Early Diagnosis of Actinic Keratosis

Contact Info

Product

Resources

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Overlapping tumor‐specific expression of p53, p16^INK4a, and sirtuin 1 in Bowen's disease: A case report