Overview of Embolotherapy: Agents, Indications, Applications, and Nursing Management

Schwaner, Sandra L.; Haug, Stephen B.; Matsumoto, Alan H.

doi:10.1016/j.cpen.2010.02.006

Cited by 3 publications

(2 citation statements)

References 51 publications

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“…Liquid materials have been used for arteriovenous embolization, which are more suitable for vascular pedicles with rapid flow rate 5 . Thrombin, sclerosants (such as Ethanol, Sodium Tetradecyl Sulfate) and embolic polymers (such as NBCA glue, Ethylene Vinyl Alcohol/Onyx) were the conventional liquid embolic agents 6 . The most reported liquid embolic agent used in the TACE for HCC was lipiodol, which has been used in clinical trials 7 .…”

Section: Introductionmentioning

confidence: 99%

Phytantriol based liquid crystal provide sustained release of anticancer drug as a novel embolic agent

Qin

Mei

Shan

et al. 2015

Drug Development and Industrial Pharmacy

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Phytantriol has received increasing amount of attention in drug delivery system, however, the ability of the phytantriol based liquid crystal as a novel embolic agent to provide a sustained release delivery system is yet to be comprehensively demonstrated. The purpose of this study was to prepare a phytantriol-based cubic phase precursor solution loaded with anticancer drug hydroxycamptothecine (HCPT) and evaluate its embolization properties, in vitro drug release and cytotoxicity. Phase behavior of the phytantriol-solvent-water system was investigated by visual inspection and polarized light microscopy, and no phase transition was observed in the presence of HCPT within the studied dose range. Water uptake by the phytantriol matrices was determined gravimetrically, suggesting that the swelling complied with the second order kinetics. In vitro evaluation of embolic efficacy indicated that the isotropic solution displayed a satisfactory embolization effect. In vitro drug release results showed a sustained-release up to 30 days and the release behavior was affected by the initial composition and drug loading. Moreover, the in vitro cytotoxicity and anticancer activity were evaluated by MTT assay. No appreciable mortality was observed for NIH 3T3 cells after 48 h exposure to blank formulations, and the anticancer activity of HCPT-loaded formulations to HepG2 and SMMC7721 cells was strongly dependent on the drug loading and treatment time. Taken together, these results indicate that phytantriol-based cubic phase embolic gelling solution is a promising potential carrier for HCPT delivery to achieve a sustained drug release by vascular embolization, and this technology may be potential for clinical applications.

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Section: Introductionmentioning

confidence: 99%

Phytantriol based liquid crystal provide sustained release of anticancer drug as a novel embolic agent

Qin

Mei

Shan

et al. 2015

Drug Development and Industrial Pharmacy

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“…Permanent agents are designed to provide irreversible blood flow obstruction to target lesions or final organs. In particular for the permanent embolic agent, the most used materials are coils, plugs, detachable balloons (solid agents), polyvinyl alcohol, compressible microspheres, thrombin, dehydrated alcohol, sodium tetradecyl sulfate, glues, and onyx (liquid agents) [23,24].…”

Section: Introductionmentioning

confidence: 99%

Well Defined Poly(Methyl Methacrylate)-Fe3O4/Poly(Vinyl Pivalate) Core–Shell Superparamagnetic Nanoparticles: Design and Evaluation of In Vitro Cytotoxicity Activity Against Cancer Cells

et al. 2020

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The objective of this work is to develop and characterize polymeric nanoparticles with core–shell morphology through miniemulsion polymerization combined with seeded emulsion polymerization, aiming at the application in the treatment of vascular tumors via intravascular embolization. The synthesis of the core–shell nanocomposites was divided into two main steps: (i) Formation of the core structure, consisting of poly(methyl methacrylate)/magnetic oxide coated with oleic acid (OM-OA) via miniemulsion and (ii) shell structure produced through seeded emulsion polymerization of vinyl pivalate. Nanocomposites containing about 8 wt.% of OM-OA showed high colloidal stability, mean diameter of 216.8 nm, spherical morphology, saturation magnetization (Ms) of 4.65 emu·g−1 (57.41 emu·g−1 of Fe3O4), preserved superparamagnetic behavior and glass transition temperature (Tg) of 111.8 °C. TEM micrographs confirmed the obtaining of uniformly dispersed magnetic nanoparticles in the PMMA and that the core–shell structure was obtained by seeded emulsion with Ms of 1.35 emu·g−1 (56.25 emu·g−1 of Fe3O4) and Tg of 114.7 °C. In vitro cytotoxicity assays against murine tumor of melanoma (B16F10) and human Keratinocytes (HaCaT) cell lines were carried out showing that the core–shell magnetic polymeric materials (a core, consisting of poly(methyl methacrylate)/Fe3O4 and, a shell, formed by poly(vinyl pivalate)) presented high cell viabilities for both murine melanoma tumor cell lines, B16F10, and human keratinocyte cells, HaCaT.

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Embolizacion prequirúrgica del hemangiopericitoma en la región lumbosacra

Nielsen¹,

Padilla²,

Feldman³

et al. 2014

Revista Argentina de Radiología

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Overview of Embolotherapy: Agents, Indications, Applications, and Nursing Management

Cited by 3 publications

References 51 publications

Phytantriol based liquid crystal provide sustained release of anticancer drug as a novel embolic agent

Phytantriol based liquid crystal provide sustained release of anticancer drug as a novel embolic agent

Well Defined Poly(Methyl Methacrylate)-Fe3O4/Poly(Vinyl Pivalate) Core–Shell Superparamagnetic Nanoparticles: Design and Evaluation of In Vitro Cytotoxicity Activity Against Cancer Cells

Embolizacion prequirúrgica del hemangiopericitoma en la región lumbosacra

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