Overview of epidemiology and disease burden of hepatitis B in the European region

Roure, C.

doi:10.1016/0264-410x(95)80041-b

Cited by 32 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Frequencies of HGV infection of 1–4% have been reported in volunteer blood donor populations from a number of different geographical locations 1 , 6 , 8 , 9 , 11 . In Thailand, where hepatitis B infection is relatively common, we have detected HGV in 5% of voluntary blood donors, a prevalence similar to that found in HBV‐non‐endemic areas such as Australia and Europe 17 –20 …”

Section: Discussionsupporting

confidence: 75%

High prevalence of hepatitis G virus infection in multiply transfused children with thalassaemia

Poovorawan

Theamboonlers

Chongsrisawat

et al. 1998

J of Gastro and Hepatol

View full text Add to dashboard Cite

We investigated the prevalence of hepatitis G virus (HGV) RNA in relation to the frequency of blood transfusions in thalassaemic children and in volunteer blood donors in Thailand. Furthermore, we studied the frequency of coinfection with hepatitis B virus (HBV) and/or hepatitis C virus (HCV) as well as a possible relationship to the alanine aminotransferase (ALT) status of the blood samples, taken at random from thalassaemic children who have received multiple blood transfusions and from volunteer blood donors. The results show detectable HGV-RNA in 32.6% of transfusion patients and in 5% of blood donors. The prevalence of HGV-RNA peaked between the 11th and 50th transfusion. The relationship between HGV infection and ALT status was not statistically relevant.

show abstract

Section: Discussionsupporting

confidence: 75%

High prevalence of hepatitis G virus infection in multiply transfused children with thalassaemia

Poovorawan

Theamboonlers

Chongsrisawat

et al. 1998

J of Gastro and Hepatol

View full text Add to dashboard Cite

show abstract

“…Previous studies had shown that Romania is a high endemic region for HBV infection (> 7% population prevalence for all hepatitis B markers),[5] mostly acquired in childhood by either maternal-fetal or parenteral routes. The frequency of asymptomatic hepatitis cases has important public health consequences concerning the transmission route and the effective prophylactic measures.…”

Section: Discussionmentioning

confidence: 99%

High Prevalence of Hepatitis B Virus Markers in Romanian Adolescents With Human Immunodeficiency Virus Infection

Ruță¹,

Mătuşa²,

Sultana³

et al. 2005

Journal of the International AIDS Society

View full text Add to dashboard Cite

BackgroundWe evaluated the frequency of hepatitis coinfection in Romanian adolescents who were diagnosed with human immunodeficiency virus (HIV) infection prior to 1995.MethodsOne hundred sixty-one adolescents (13–18 years of age) with symptomatic HIV infection, but without signs of hepatic dysfunction, and 356 age-matched, HIV-uninfected controls underwent laboratory testing for markers of parenterally acquired hepatitis virus infection.ResultsSeventy-eight percent of HIV-infected adolescents had markers of past or present hepatitis B virus (HBV) infection, as compared with 32% of controls (P = .0001). The prevalence of HBV replicative markers was more than 5-fold higher in HIV-infected adolescents as compared with controls: 43.4% vs 7.9% (P = .0001), respectively, for hepatitis B surface antigen (HBsAg); and 11.2% vs 2.2% (P = .0001), respectively, for hepatitis B e antigen (HBeAg). The prevalence of HBsAg chronic carriers and the presence of HBV replicative markers was significantly higher in patients with immunologically defined AIDS (CD4+ cell counts < 200 cells/mcL): 59.6% vs 34.6% (P = .02) for HBsAg and 22.8% vs 5.7%, (P = .002) for HBV DNA. After 1 year of follow-up, the proportion of those who cleared the HBeAg was considerably lower in severely immunosuppressed coinfected patients: 4.7% vs 37.1% (P = .003). Four additional HIV-infected adolescents became HBsAg-positive over the term of follow-up (incidence rate, 24.9/1000 person-years), despite a record of immunization against hepatitis B.ConclusionA substantial percentage of HIV-infected and HIV-uninfected Romanian adolescents have evidence of past or present HBV infection. In HIV-infected adolescents, the degree of immunosuppression is correlated with persistence of HBV replicative markers, even in the absence of clinical or biochemical signs of liver disease.

show abstract

“…Of these, about 90 000 will become chronically infected carriers and about 22 000 will die from cirrhosis and liver cancer 4. Unexpectedly high prevalences of hepatitis B carriage have been found in many parts of central and eastern Europe and the newly independent states of the former Soviet Union.…”

Section: Size Of the Problemmentioning

confidence: 99%

“…In the Central Asian republics of the former Soviet Union and in some countries of central and eastern Europe (such as Albania, Bulgaria, Moldova, Romania), hepatitis B is a serious threat to community health, with an estimated annual incidence of 520 infections/100 000. These countries have intermediate or high endemicity 4. The remaining countries of central and eastern Europe have an estimated annual incidence of 130 infections/100 000.…”

Section: Size Of the Problemmentioning

confidence: 99%

Integration of hepatitis B vaccination into national immunisation programmes

Damme

Kane

Meheus

1997

BMJ

141

View full text Add to dashboard Cite

Hepatitis B is a major public health problem even though safe and effective vaccines have been available for over 10 years. Because hepatitis B infection is largely asymptomatic with long term complications occurring after many years it has not received the attention it deserves. Strategies to immunise those at high risk have failed to control the disease. Delegates to the World Health Assembly of the World Health Organisation recommended in May 1992 that all countries should integrate hepatitis B vaccination into their national immunisation programmes by 1997. Some western European countries remain unconvinced that the burden of disease warrants the expense of universal vaccination. However, epidemiological data and economic evaluation show that universal hepatitis B vaccination is cost effective in countries with low endemicity and that it will control hepatitis B, reinforcing the necessity for action.

show abstract

Overview of epidemiology and disease burden of hepatitis B in the European region

Cited by 32 publications

References 0 publications

High prevalence of hepatitis G virus infection in multiply transfused children with thalassaemia

High prevalence of hepatitis G virus infection in multiply transfused children with thalassaemia

High Prevalence of Hepatitis B Virus Markers in Romanian Adolescents With Human Immunodeficiency Virus Infection

Integration of hepatitis B vaccination into national immunisation programmes

Contact Info

Product

Resources

About