Overview of Epidemiology of Bile Duct and Gallbladder Cancer Focusing on the JACC Study

Matsuba, Tsuyoshi; Qiu, Dongmei; Kurosawa, Michiko; Lin, Yingsong; Inaba, Yutaka; Kikuchi, Shogo; Yagyu, Kiyoko; Motohashi, Yutaka; Tamakoshi, Akiko

doi:10.2188/jea.15.s150

Cited by 23 publications

(18 citation statements)

References 13 publications

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“…The two patients were younger than the peak age (50 years or older) of cholangiocarcinoma onset 10,11) . The risk factors for cholangiocarcinoma include liver fluke infection, primary sclerosing cholangitis, biliary malformation, biliary stone, viral hepatitis, heavy drinking and smoking, and exposure to chemicals such as thorotrast 12) .…”

Section: Discussionmentioning

confidence: 89%

Two Offset Printing Workers with Cholangiocarcinoma

Kumagai

2014

Journal of Occupational Health

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Section: Discussionmentioning

confidence: 89%

Two Offset Printing Workers with Cholangiocarcinoma

Kumagai

2014

Journal of Occupational Health

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“…Although gallstones are a risk factor common to all three subsites of biliary cancer, differences in the magnitude of risks and in the prevalence and type of stones were notable. Molecular changes, including somatic mutations (such as K-ras and P16) and loss of heterozygosity, in these subsites have been described (Rashid et al, 2002;Ueki et al, 2004;Matsuba et al, 2005). Aetiologic heterogeneity is further supported by ethnic and geographic patterns between cancer subsites, with gallbladder cancer incidence especially high in native Americans and in Korea, India, and Eastern Europe, and the incidence of bile duct cancer highest in Japan .…”

Section: Discussionmentioning

confidence: 99%

Gallstones and the risk of biliary tract cancer: a population-based study in China

et al. 2007

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We conducted a population-based study of 627 patients with biliary tract cancers (368 of gallbladder, 191 bile duct, and 68 ampulla of Vater), 1037 with biliary stones, and 959 healthy controls randomly selected from the Shanghai population, all personally interviewed. Gallstone status was based on information from self-reports, imaging procedures, surgical notes, and medical records. Among controls, a transabdominal ultrasound was performed to detect asymptomatic gallstones. Gallstones removed from cancer cases and gallstone patients were classified by size, weight, colour, pattern, and content of cholesterol, bilirubin, and bile acids. Of the cancer patients, 69% had gallstones compared with 23% of the population controls. Compared with subjects without gallstones, odds ratios associated with gallstones were 23.8 (95% confidence interval (CI), 17.0 -33.4), 8.0 (95% CI 5.6 -11.4), and 4.2 (95% CI 2.5 -7.0) for cancers of the gallbladder, extrahepatic bile ducts, and ampulla of Vater, respectively, persisting when restricted to those with gallstones at least 10 years prior to cancer. Biliary cancer risks were higher among subjects with both gallstones and self-reported cholecystitis, particularly for gallbladder cancer (OR ¼ 34.3, 95% CI 19.9 -59.2). Subjects with bile duct cancer were more likely to have pigment stones, and with gallbladder cancer to have cholesterol stones (Po0.001). Gallstone weight in gallbladder cancer was significantly higher than in gallstone patients (4.9 vs 2.8 grams; P ¼ 0.001). We estimate that in Shanghai 80% (95% CI 75 -84%), 59% (56 -61%), and 41% (29 -59%) of gallbladder, bile duct, and ampulla of Vater cancers, respectively, could be attributed to gallstones. Cancers of the biliary tract encompass those arising from the gallbladder, extrahepatic bile ducts, and ampulla of Vater. Biliary cancer is relatively uncommon in most parts of the world, although high-risk populations and upward incidence trends have been reported in certain areas . Although gallstones are a well-documented risk factor for gallbladder cancer (Diehl, 1983(Diehl, , 1991Zatonski et al, 1997;Lazcano-Ponce et al, 2001;Hsing et al, 2006), their role in cancers of the extrahepatic bile duct and ampulla of Vater is less established.From 1972 to 1994, biliary tract cancer was the most rapidly rising malignancy in Shanghai , involving all three subsites, both sexes, and all age groups. We therefore conducted a population-based case -control study there in 1997 to 2001 to assess the role of gallstones for each biliary cancer subsite. MATERIALS AND METHODS Cancer casesThe study was approved by the Institutional Review Boards at both the National Cancer Institute and the Shanghai Cancer Institute. Informed consent was obtained for all subjects. Patients with primary biliary tract cancer (ICD9 156), newly diagnosed between June 1997 and May 2001, were identified through a rapid-reporting system established between the Shanghai Cancer Institute and 42 collaborating hospitals in 10 urban districts of Shanghai (henceforth r...

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“…The workers were in their 30 s to 50 s when they were diagnosed. Given the low prevalence of cholangiocarcinoma in these age groups among the general population 6,7) , the fact that two workers were identified with this cancer in each of the small plants strongly suggests that some This study aimed to identify chemicals used by printing workers with cholangiocarcinoma, as well as the levels of exposure to the chemicals. Methods: Information necessary to identify chemicals used by printing workers with cholangiocarcinoma and to estimate chemical exposure concentrations was obtained from the Ministry of Health, Labour and Welfare, Japan.…”

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confidence: 99%