Overview of Hydroxychloroquine and Remdesivir on severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)

The alkali metal tert‐butoxides have found wide application as catalysts and activators for the conversion of numerous organic molecules. These formidable additives in catalytic amounts are extensively employed in the transition metal‐free approaches to serve for the single‐electron transfer processes towards the formation of C−C and C‐heteroatom bond formation. This review elucidates their multifaceted roles encompassing a series of novel synthetic methodologies, in‐depth analyses of their reactivity patterns, and catalytic efficiencies across a myriad of reactions. The involvement of alkali metal tert‐butoxides either directly or in combination with other metals as catalysts are discussed along with the detailed mechanistic pathways in various reactions. Overall, this article summarises approximately all reactions those have been influenced by the catalytic amounts of tert‐butoxides and reported in the last decades.

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Roles of Alkali Metals tert‐Butoxide as Catalysts and Activators in Organic Transformations

Patel

Banerjee

Kant

et al. 2023

Asian J Org Chem

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Targeting SARS‐CoV‐2 Proteins: In Silico Investigation with Polypyridyl‐Based Zn(II)‐Curcumin Complexes

Gawande,

Kushwaha,

Mandal

et al. 2024

ChemBioChem

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Herein, we have selected eight Zn(II)‐based complexes viz., [Zn(bpy)(acac)Cl] (1), [Zn(phen)(acac)Cl] (2), [Zn(dppz)(acac)Cl] (3), [Zn(dppn)(acac)Cl] (4), [Zn(bpy)(cur)Cl] (5), [Zn(phen)(cur)Cl] (6), [Zn(dppz)(cur)Cl] (7), [Zn(dppn)(cur)Cl] (8), where bpy=2,2'‐bipyridine, phen=1,10‐phenanthroline, dppz=benzo[i]dipyrido[3,2‐a:2',3'‐c]phenazine, dppn=naphtho[2,3‐i]dipyrido[3,2‐a:2',3'‐c]phenazine, acac=acetylacetonate, cur=curcumin and performed in silico molecular docking studies with the viral proteins, i.e., spike protein (S), Angiotensin‐converting enzyme II Receptor protein (ACE2), nucleocapsid protein (N), main protease protein (Mpro), and RNA‐dependent RNA polymerase protein (RdRp) of SARS‐CoV‐2. The binding energy calculations, visualization of the docking orientation, and analysis of the interactions revealed that these complexes could be potential inhibitors of the viral proteins. Among complexes 1‐8, complex 6 showed the strongest binding affinity with S and ACE2 proteins. 4 exerted better binding affinity in the case of the N protein, whereas 8 presented the highest binding affinities with Mpro and RdRp among all the complexes. Overall, the study indicated that Zn(II) complexes have the potential as alternative and viable therapeutic solutions for COVID‐19.

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Overview of Hydroxychloroquine and Remdesivir on severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)

Kabi

Pal

Gujjarappa

et al. 2022

Journal of Heterocyclic Chem

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The novel severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) caused the ongoing pandemic named COVID‐19 which causes a serious emergency on public health hazards of international concern. In the face of a critical medical emergency, repositioning of drugs is one of the most authentic options to design an adequate treatment for infected patients immediately. In this strategy, Remdesivir (Veklury), Hydroxychloroquine appears to be the drug of choice and garnered unprecedented attention as potential therapeutic agents against the pandemic realized worldwide due to SARS‐CoV‐2 infection. These are the breathtaking instances of possible repositioning of drugs, whose pharmacokinetics and optimal dosage are familiar. In this review, we provide an overview of these medications, their synthesis, and the possible mechanism of action against SARS‐CoV‐2.

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Overview of Hydroxychloroquine and Remdesivir on severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)

Cited by 6 publications

References 123 publications

Roles of Alkali Metals tert‐Butoxide as Catalysts and Activators in Organic Transformations

Roles of Alkali Metals tert‐Butoxide as Catalysts and Activators in Organic Transformations

Targeting SARS‐CoV‐2 Proteins: In Silico Investigation with Polypyridyl‐Based Zn(II)‐Curcumin Complexes

Overview of Hydroxychloroquine and Remdesivir on severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)

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