Overview of hypercalcemia of malignancy

Solimando, Dominic A.

doi:10.1093/ajhp/58.suppl_3.s4

Cited by 27 publications

(20 citation statements)

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“…Moreover four glands, which were strongly and diffusely calcitonin positive, were all chromogranin B negative suggesting that calcitonin expression may be independent of chromogranin B expression. Calcitonin along with the parathyroid hormone and calcitetrol (1,25[OH] 2 D 3 ) plays a major role in calcium homeostasis [23][24][25]. High serum calcium levels induce the release of calcitonin from the thyroid C cells, which by its action of inhibiting osteoclastic activity reduces the serum calcium level.…”

Section: Discussionmentioning

confidence: 99%

Calcitonin immunoreactivity in neoplastic and hyperplastic parathyroid glands: an immunohistochemical study

et al. 2003

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CgB, SYN, and CD57 are markers for subsets of hyperplastic and neoplastic parathyroid glands. CT is also expressed in a significant proportion of hyperplastic and neoplastic parathyroid glands, and may be independent of the presence of CgB, SYN, or DD57. The significance of these findings in relationship to the abnormal calcium metabolism in patients with parathyroid hyperplasia remains to be determined.

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Section: Discussionmentioning

confidence: 99%

Calcitonin immunoreactivity in neoplastic and hyperplastic parathyroid glands: an immunohistochemical study

et al. 2003

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“…In diesem Lebensalter sollte unbedingt eine multiple endokrine Neoplasie Typ 1 ausgeschlossen werden . 65% aller im Spital diagnostizierten Hyperkalzämien werden durch Malignome verursacht und bis zu 10-30% aller Krebspatienten sind von einer Hyperkalziämie betroffen [69] . Mamma-und Bronchialkarzinome sind für ~ 50% der Tumorhyperkalziämien verantwortlich [70] .…”

Section: Epidemiologieunclassified

Endokrinologische Notfälle

Wohlschläger-Krenn

Luger

Gessl

2010

Wiener Klin. Wochenschr. Educ.

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“…È la complicanza metabolica più frequente in assoluto, con un'incidenza intorno al 10% 66 . La neoplasia induce ipercalcemia attraverso un meccanismo locale legato alla produzione di varie citochine che inducono la mobilizzazione del calcio dall'osso (meccanismo paracrino); inoltre molti fattori umorali rilasciati in circolo dal tumore, segnatamente la proteina correlata al paratormone (PTHrP), stimolano la mobilizzazione dall'osso e il riassorbimento renale del calcio (meccanismo endocrino), portando all'ipercalcemia.…”

Section: L'ipercalcemiaunclassified

I tumori del rachide

Ferraú¹,

Antonelli²

2002

Rivista di Neuroradiologia

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RIASSUNTO -Il sistema scheletrico rappresenta nei tumori solidi la terza sede metastatica in ordine di frequenza, dopo fegato e polmoni. Di tutti i segmenti ossei, il rachide risulta essere quello maggiormente interessato. Dal punto di vista prognostico, il coinvolgimento osseo consente sopravvivenze relativamente più lunghe, ma è in grado di condizionare la qualità di vita pesantemente. L'integrazione terapeutica multispecialistica è indispensabile per una corretta valutazione diagnostica e terapeutica. Il trattamento comprende il controllo della malattia neoplastica di base e la terapia delle manifestazioni conseguenti alle metastasi ossee: compressione midollare, dolore, ipercalcemia, complicanze internistiche. Il trattamento oncologico specifico dipende fondamentalmente dallo stadio di malattia, dall'eventuale concomitante coinvolgimento viscerale, dalla ormonodipendenza e dalla chemiosensibilità della patologia neoplastica di base. SUMMARY -The skeleton is the third most common site of metastases after the liver and lung. Of all bone segments, the spine is the most frequently affected. In terms of prognosis, patients with bone involvement have a relatively long survival rate, but a poor quality of life. A multidisciplinary approach is essential for accurate diagnostic and therapeutic assessment. Treatment includes control of the primary tumour and therapy for the signs and symptoms of bone metastases: cord compression, pain, hypercalcaemia and internal complications.Specific cancer treatment basically depends on the disease stage, possible concomitant visceral involvement, hormone dependence and chemosensitivity of the primary tumour.

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Overview of hypercalcemia of malignancy

Cited by 27 publications

References 0 publications

Calcitonin immunoreactivity in neoplastic and hyperplastic parathyroid glands: an immunohistochemical study

Calcitonin immunoreactivity in neoplastic and hyperplastic parathyroid glands: an immunohistochemical study

Endokrinologische Notfälle

I tumori del rachide

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