Overview of in situ gelling injectable hydrogels for diabetic wounds

Mude, Lavanya; Sanapalli, Bharat Kumar Reddy; Vadakkepushpakath, Anoop Narayanan; Singh, Sachin Kumar; Karri, Veera Venkata Satyanarayana Reddy

doi:10.1002/ddr.21788

Cited by 28 publications

(10 citation statements)

References 144 publications

(149 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The swelling properties of hydrogels play a critical role in absorbing extrude in the diabetic wound [ 20 ]. In this study, all the hydrogels displayed similar swelling kinetics ( Figure 4 e).…”

Section: Resultsmentioning

confidence: 99%

Precise Design of Alginate Hydrogels Crosslinked with Microgels for Diabetic Wound Healing

Yan

Ren

et al. 2022

Biomolecules

View full text Add to dashboard Cite

Alginate hydrogel has received great attention in diabetic wound healing. However, the limited tunability of the ionic crosslinking method prevents the delicate management of physical properties in response to diverse wound conditions. We addressed this issue by using a microgel particle (fabricated by zinc ions and coordinated through the complex of carboxymethyl chitosan and aldehyde hyaluronic acid) as a novel crosslinker. Then the cation was introduced as a second crosslinker to create a double crosslinked network. The method leads to the precise regulation of the hydrogel characters, including the biodegradation rate and the controlled release rate of the drug. As a result, the optimized hydrogels facilitated the live-cell infiltration in vitro and boosted the tissue regeneration of diabetic wounds in vivo. The results indicated that the addition of the microgel as a new crosslinker created flexibility during the construction of the alginate hydrogel, adapting for diverse applications during diabetic-induced wound therapy.

show abstract

Section: Resultsmentioning

confidence: 99%

Precise Design of Alginate Hydrogels Crosslinked with Microgels for Diabetic Wound Healing

Yan

Ren

et al. 2022

Biomolecules

View full text Add to dashboard Cite

show abstract

“…However, these dressings still have some limitations. Their advantages and drawbacks are shown in Table 1 below [ 31 ]. Therefore, it is urgently required to identify new smart biomaterials for the treatment of diabetic wounds.…”

Section: Wound Healingmentioning

confidence: 99%

Construction of Smart Biomaterials for Promoting Diabetic Wound Healing

Huang

Yuan

et al. 2023

Molecules

View full text Add to dashboard Cite

Diabetes mellitus is a complicated metabolic disease that has become one of the fastest-growing health crises in modern society. Diabetic patients may suffer from various complications, and diabetic foot is one of them. It can lead to increased rates of lower-extremity amputation and mortality, even seriously threatening the life and health of patients. Because its healing process is affected by various factors, its management and treatment are very challenging. To address these problems, smart biomaterials have been developed to expedite diabetic wound closure and improve treatment outcomes. This review begins with a discussion of the basic mechanisms of wound recovery and the limitations of current dressings used for diabetic wound healing. Then, the categories and characteristics of the smart biomaterial scaffolds, which can be utilized as a delivery system for drugs with anti-inflammatory activity, bioactive agency, and antibacterial nanoparticles for diabetic wound treatment were described. In addition, it can act as a responsive system to the stimulus of the pH, reactive oxygen species, and glucose concentration from the wound microenvironment. These results show that smart biomaterials have an enormous perspective for the treatment of diabetic wounds in all stages of healing. Finally, the advantages of the construction of smart biomaterials are summarized, and possible new strategies for the clinical management of diabetic wounds are proposed.

show abstract

“…Injectable hydrogels are often used for controlled and local drug delivery because of their easily adjustable volume, shape, etc ( Dimatteo et al, 2018 ; Rizzo and Kehr, 2021 ). On the one hand, since the injectable hydrogels are cross-linked in-situ , it is more readily to control the gelation time and avoid the shear stress during injection process to affect the performance of hydrogels ( Mude et al, 2021 ). On the other hand, advantages of albumin-based hydrogels as in situ injectable hydrogels for antitumor applications are mainly in terms of degradability and morphological modifiability.…”

Section: Two Key Applications Of Albumin-based Hydrogelsmentioning

confidence: 99%

Research progress on albumin-based hydrogels: Properties, preparation methods, types and its application for antitumor-drug delivery and tissue engineering

Meng

Zhu

Deng

et al. 2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Albumin is derived from blood plasma and is the most abundant protein in blood plasma, which has good mechanical properties, biocompatibility and degradability, so albumin is an ideal biomaterial for biomedical applications, and drug-carriers based on albumin can better reduce the cytotoxicity of drug. Currently, there are numerous reviews summarizing the research progress on drug-loaded albumin molecules or nanoparticles. In comparison, the study of albumin-based hydrogels is a relatively small area of research, and few articles have systematically summarized the research progress of albumin-based hydrogels, especially for drug delivery and tissue engineering. Thus, this review summarizes the functional features and preparation methods of albumin-based hydrogels, different types of albumin-based hydrogels and their applications in antitumor drugs, tissue regeneration engineering, etc. Also, potential directions for future research on albumin-based hydrogels are discussed.

show abstract

Overview of in situ gelling injectable hydrogels for diabetic wounds

Cited by 28 publications

References 144 publications

Precise Design of Alginate Hydrogels Crosslinked with Microgels for Diabetic Wound Healing

Precise Design of Alginate Hydrogels Crosslinked with Microgels for Diabetic Wound Healing

Construction of Smart Biomaterials for Promoting Diabetic Wound Healing

Research progress on albumin-based hydrogels: Properties, preparation methods, types and its application for antitumor-drug delivery and tissue engineering

Contact Info

Product

Resources

About