Overview of iron metabolism in health and disease

Dev, Som; Babitt, Jodie L.

doi:10.1111/hdi.12542

Cited by 360 publications

(313 citation statements)

References 154 publications

(290 reference statements)

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“…The results of the current study show there is a negative influence of Fe overload and Fe deficiency on blood vessels. This is in agreement with the report by Dev and Babitt indicating that the influence of Fe overload includes oxidant‐mediated injury, interference with cardiac electrical function, and promotion of vascular fibrosis. Fe deficiency also has adverse consequences on the heart and blood vessels.…”

Section: Resultssupporting

confidence: 93%

“…Fe deficiency also has adverse consequences on the heart and blood vessels, organs with high energy demands. Some epidemiologic studies in the general population have demonstrated an association between increased heme Fe intake, body Fe stores, and cardiovascular risk . Current European Society of Cardiology guidelines for the diagnosis and management of acute and chronic heart failure recommend assessment of Fe parameters, with ensuing Fe therapy in cases of Fe deficiency…”

Section: Introductionmentioning

confidence: 99%

“…Some epidemiologic studies in the general population have demonstrated an association between increased heme Fe intake, body Fe stores, and cardiovascular risk. 5 Current European Society of Cardiology guidelines for the diagnosis and management of acute and chronic heart failure recommend assessment of Fe parameters, with ensuing Fe therapy in cases of Fe deficiency. 6 In general, the origin of Fe deficiency is related to reduced Fe intake, increased Fe losses, and/or the abnormal Fe distribution when it is functionally not available for the body.…”

Section: Introductionmentioning

confidence: 99%

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Fermented goat milk consumption improves cardiovascular health during anemia recovery

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Section: Resultssupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Fermented goat milk consumption improves cardiovascular health during anemia recovery

et al. 2018

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“…In human beings, it can act as a key component embedded into proteins (e.g., hemoglobin, myoglobin), be a part of enzymes (e.g., myeloperoxidase, nitric oxide synthetases, DNA primase) or play a major role in aerobic electron energy transfer (e.g., respiratory complexes I-III, coenzyme Q10) [8,9]. Our bodies contain about 3-4 g of iron in a heme and non-heme form, though only the minority of it is circulating in the plasma bound to plasma proteins, mainly transferrin [7]. Because of their high reactivity both, ferric (Fe3+) and ferrous (Fe2+) iron are well-protected by chaperones or chelators.…”

Section: Physiology Of Iron In Inflammation and Ros Productionmentioning

confidence: 99%

Iron Chelation as Novel Treatment for Interstitial Cystitis

et al. 2019

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Interstitial cystitis (IC) is a highly prevalent debilitating disease, with its cardinal symptoms being severe pain, urinary urgency and frequency. The associated pain may eventually lead as a last resort to removal of the bladder. Though the initial trigger for IC remains largely unknown, we propose novel iron chelators as a possible new treatment for this disease. Iron is a mandatory component for the generation of reactive oxygen species (ROS). A substantial decrease in ROS production and thus inflammation can be achieved by effectively sequestering host iron, which we believe may improve outcome and quality of life in IC patients. Novel iron chelators could be used via the intravesical route to reduce or attenuate inflammation by effectively sequestering host iron, thus preventing the production of ROS via the Fenton and Haber-Weiss reactions.

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“…Sin embargo, su exceso genera estrés oxidativo, que es también dañino para la función y supervivencia de las células y tejidos. Por ello es importante mantener la homeostasis del hierro (Figura 2) (14,15) . Uno de los mecanismos que utiliza el organismo para mantener la homeostasis del hierro es evitar su excreción; así, las pérdidas por descamación de células entéricas y otras son del nivel de 1 mg diario, que es lo que habría que reponer con la dieta.…”

Section: Requerimiento De Hierrounclassified

Necesidades de investigación para el diagnóstico de anemia en poblaciones de altura

Gonzáles

Fano

2017

Rev Peru Med Exp Salud Publica

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RESUMENTanto la deficiencia como la sobrecarga de hierro son situaciones que ponen en riesgo la salud y la vida de las personas, por lo que es importante mantener su homeostasis. Como la hemoglobina contiene 70% del hierro del organismo, la OMS recomienda su medición para determinar la prevalencia de anemia por deficiencia de hierro (ID), a pesar que ellos mismos reconocen que la anemia no es específica de ID. Como la hemoglobina aumenta con la altitud de residencia, la OMS recomienda corregir el punto de corte para definir anemia en la altura. Una objeción a esta corrección es que el aumento de la hemoglobina en la altura no es universal ni aumenta de manera lineal. Además, las poblaciones de mayor antigüedad generacional tienen menos hemoglobina que las más recientes. En infantes, niños, gestantes y adultos, la prevalencia de anemia usando hemoglobina corregida es 3-5 veces mayor que usando marcadores del estatus de hierro. Los programas estatales buscan combatir la anemia mediante la suplementación de hierro; no obstante, resultan ineficaces, especialmente en las poblaciones de altura. Entonces, ¿hay deficiencia de hierro en la altura? Los niveles de hepcidina sérica, hormona que regula la disponibilidad de hierro, son similares a los de nivel del mar indicando que en la altura no hay deficiencia de hierro. Un problema adicional al corregir la hemoglobina por la altura, es que las prevalencias de eritrocitosis disminuyen. En conclusión, la corrección del punto de corte de la hemoglobina en la altura para determinar deficiencia de hierro es inadecuada. Palabras clave: Anemia, Deficiencia de hierro, Factor de corrección, Ferritinas (fuente: DeCS BIREME). DIAGNOSIS OF ANEMIA IN POPULATIONS AT HIGH ALTITUDES ABSTRACTIron deficiency and overload are risk factors for numerous poor health outcomes, and thus the maintenance of iron homeostasis is vital. Considering that hemoglobin contains 70% of the total iron in the body, the World Health Organization (WHO) recommends the measurement of iron levels to calculate the rate of iron deficiency anemia (IDA), although WHO recognizes that IDA is not the only cause of anemia. As hemoglobin increases with altitude, WHO recommends correcting the cut-off point to define anemia at high altitudes. An objection to this correction is that the increase in hemoglobin at high altitudes is not universal and is not linear. In addition, individuals in older age groups have lower hemoglobin levels than those in younger age groups. In infants, children, pregnant women, and adults, the prevalence of anemia using corrected hemoglobin is 3-5 times higher than that using markers of iron status. State programs seek to control anemia by means of iron supplementation. However, these programs are ineffective, particularly for high-altitude populations. Therefore, the occurrence of iron deficiency at high altitudes is controversial. The serum levels of the hormone hepcidin, which regulates iron availability, are similar in individuals at high altitudes to those of individuals at sea level, indicat...

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Overview of iron metabolism in health and disease

Cited by 360 publications

References 154 publications

Fermented goat milk consumption improves cardiovascular health during anemia recovery

Fermented goat milk consumption improves cardiovascular health during anemia recovery

Iron Chelation as Novel Treatment for Interstitial Cystitis

Necesidades de investigación para el diagnóstico de anemia en poblaciones de altura

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