Overview of known non-human primate pathogens with potential to affect colonies used for toxicity testing

Pathogenic Simian Immunodeficiency Virus Infection Is Associated with Expansion of the Enteric Virome

“…As previously observed by others using classical virologic methods (Bailey and Mansfield, 2010; Oberste et al, 2002, 2007; Sasseville and Mansfield, 2010; Wang et al, 2007), picornaviruses were detected in both control and SIV-infected rhesus monkeys (Figure 2, Table S1). This allowed us to compare the number of sequences detected in pathogenic SIV-infected and control rhesus monkeys (Figure 2F).…”

“…Herein, we will define viruses that infect eukaryotic cells as the virome (Virgin et al, 2009). Indeed, primate species used in SIV research can be infected with a range of enteropathogenic viruses (Farkas et al, 2008; Oberste et al, 2002, 2007; Sasseville and Mansfield, 2010; Wang et al, 2007). …”

Naturally occurring infections in non-human primates (NHP) and immunotoxicity implications: Discussion sessions

“…For the most informed path forward, it is important to understand the interaction between the infectious organism and the host immune system, as is discussed in the preceeding publications of presentations during the morning sessions (Hutto, 2010;Lerche, 2010;Price, 2010;Sasseville and Mansfield, 2010;Simmons, 2010;Taylor, 2010).…”

Worker Health and Safety Practices in Research Facilities Using Nonhuman Primates, North America

“…Infectious diseases resulting from importation of nonhuman primates need to be prevented to ensure that colonies of these animals are available for research and to protect persons working with them from exposure to established and emerging zoonotic diseases ( 2 , 3 ). …”

“…However, many zoonotic agents can be difficult to exclude from even meticulously controlled breeding facilities ( 3 , 5 ). Nonhuman primates are commonly imported from regions with a high prevalence of potentially zoonotic diseases, such as tuberculosis and meliodosis, in humans and animals.…”