Overview of non-steroidal anti-inflammatory drugs (nsaids) in resource limited countries

Fokunang, Charles; Fokunang, Estella Tembe; Frederick, Kechia; Ngameni, B; Ngadjui, Bonaventure T.

doi:10.15406/mojt.2018.04.00081

Cited by 66 publications

(34 citation statements)

References 31 publications

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“…Unfortunately, the management of pain and inflammation is expensive, and it typically entails the administration of different classes of analgesic and anti-inflammatory drugs, which are affected by various drawbacks [7]. Most of these drugs are associated with severe side effects, such as gastric ulcers, hepatotoxicity, dependency, tolerance, nephropathy, among others [32,33,34]. It has been established that herbal remedies are cheap, readily available, effective, and with few side effects [11,35,36].…”

Section: Discussionmentioning

confidence: 99%

In vivo anti-inflammatory, anti-nociceptive, and in vitro antioxidant efficacy, and acute oral toxicity effects of the aqueous and methanolic stem bark extracts of Lonchocarpus eriocalyx (Harms.)

Moriasi

Ireri

Nelson

et al. 2021

Heliyon

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Section: Discussionmentioning

confidence: 99%

In vivo anti-inflammatory, anti-nociceptive, and in vitro antioxidant efficacy, and acute oral toxicity effects of the aqueous and methanolic stem bark extracts of Lonchocarpus eriocalyx (Harms.)

Moriasi

Ireri

Nelson

et al. 2021

Heliyon

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“…The OS and inflammatory diseases are one of the major reasons for the mortality around the world in recent decades [18,19] . So, there is a need to identify the new antiinflammatory and antioxidant drugs to get rid of acute and chronic inflammatory diseases and their side effects [20,21] .…”

Section: Research Papermentioning

confidence: 99%

Antiinflammatory Activity of Wheat Grass Fortified with Cow Urine Distillate

Killari¹,

Prasad²,

Talluri³

et al. 2019

pharmaceutical-sciences

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Killari et al.: Antiinflammatory activity of Fortified Triticum aestivum with Cow urine Cow urine distillate appear to possess bioenhancement capacity that increases effectiveness of medicinal products. So, the current research was aimed to evaluate the antiinflammatory and antioxidant activity of wheat grass powder fortified with cow urine distillate. Antiinflammatory activity was studied using carrageenan-induced paw edema in Wistar rats at 100, 200 and 400 mg/kg doses of wheat grass powder fortified with cow urine distillate and the antioxidant capacity was studied using the ferric thiocyanate method. Wheat grass powder fortified with cow urine distillate showed significant reduction (61.09 %) in peroxide production in the ferric thiocyanate method. All the three doses tested produced significant inhibition of rat paw edema in the carrageenan assay but the 400 mg/kg dose produced maximum inhibition of rat paw edema (40.06 %) at the 5 h time point compared to the control. It is possible to conclude from the results of the study that fortification of wheat grass powder with cow urine distillate enhanced the antioxidant and antiinflammatory activities and further research is necessary to understand the mechanism and phytochemicals responsible for the fortification of the activity of wheat grass.

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“…13 Presently, more than 100 NSAIDs have been tested clinically and more than 50 are there in the world market. 13,14 Nearly 35 million people are taking them on daily basis and FDA has ranked them the most frequent cause of adverse drug reactions. 15 Unfortunately, they also cause most frequently lethal drug toxicity such as gastrointestinal haemorrhage.…”

Section: Importance In Selecting the Right Nsaid In A Clinical Settingmentioning

confidence: 99%

Overview of non-steroidal anti-inflammatory drugs (nsaids) in resource limited countries

Fokunang¹

2018

MOJT

Self Cite

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The non-steroidal anti-inflammatory drugs (NSAIDs) is a drug class that groups together drugs that provide analgesic (pain-killing) and antipyretic (fever-reducing) effects, and, in higher doses, anti-inflammatory effects. The analgesic and anti-inflammatory properties acts by inhibiting two recognized isoenzymes of prostaglandin G/H synthase also known as cycl-oxygenase (COX), which are COX 1 and COX 2.The pharmacodynamic action of these drugs is mostly mediated by inhibition of COX2, while the adverse reactions are largely due to COX1 inhibition.. The NSAID selectively inhibiting COX2 were developed in the 90s to reduce the risk of gastrointestinal toxicity. NSAID use has been found to be associated with an increased risk of heart failure in several randomized clinical trials and observational studies. Nevertheless, there is still limited information on the risk of heart failure associated with the use of individual NSAIDs (both COX 2 inhibitors and traditional NSAIDs) in clinical practice in resource poor communities, and especially on their doseresponse associations. The most prominent members of this group of drugs, are aspirin, ibuprofen, naproxen, that are all available over the counter in most countries. Paracetamol (acetaminophen) is generally not considered an NSAID because it has only little antiinflammatory activity. It treats pain mainly by blocking COX-2 mostly in the central nervous system, but not much in the rest of the body. Most NSAIDs inhibit the activity of (COX-1) and COX2, and thereby the synthesis of prostalglandin and thromboxanes. It is thought that inhibiting COX-2 leads to the anti-inflammatory, analgesic and antipyretic effects and that those NSAIDs also inhibiting COX-1, particularly aspirin, may cause gastrointestinal bleeding and ulcers. This review attempts to give a comprehensive view of NSAIDs pharmacological activities, the drug class, mode of action and usage in a low income economy.

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Overview of non-steroidal anti-inflammatory drugs (nsaids) in resource limited countries

Cited by 66 publications

References 31 publications

In vivo anti-inflammatory, anti-nociceptive, and in vitro antioxidant efficacy, and acute oral toxicity effects of the aqueous and methanolic stem bark extracts of Lonchocarpus eriocalyx (Harms.)

In vivo anti-inflammatory, anti-nociceptive, and in vitro antioxidant efficacy, and acute oral toxicity effects of the aqueous and methanolic stem bark extracts of Lonchocarpus eriocalyx (Harms.)

Antiinflammatory Activity of Wheat Grass Fortified with Cow Urine Distillate

Overview of non-steroidal anti-inflammatory drugs (nsaids) in resource limited countries

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