Overview of PES biocompatible/hemodialysis membranes: PES–blood interactions and modification techniques

Irfan, Muhammad; Idris, Ani

doi:10.1016/j.msec.2015.06.035

Cited by 121 publications

(87 citation statements)

References 164 publications

(197 reference statements)

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“…Generally, hydrophilic natured membranes resists against protein adsorption, furthermore, grafting on, or blending a hydrophilic fragment with hydrophobic polymer also contributed to protein resistant surfaces. The absence of attractive forces between hydrophilic additives and hydrophobic polymer separate them in two layers, where hydrophilic fragments stretch away from the polymer surface and develop a hydrophilic‐polymeric brush that's also highly repel the protein adsorption . In Table , lesser protein adsorption was observed in all the composition, which contained hydrophobic‐hydrophilic additives.…”

Section: Discussionmentioning

confidence: 99%

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Fabrication and performance evaluation of blood compatible hemodialysis membrane using carboxylic multiwall carbon nanotubes and low molecular weight polyvinylpyrrolidone based nanocomposites

Irfan

Idris

et al. 2018

J Biomedical Materials Res

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This study focused to optimize the performance of polyethersulfone (PES) hemodialysis (HD) membrane using carboxylic functionalized multiwall carbon nanotubes (c‐MWCNT) and lower molecular weight grade of polyvinylpyrrolidone (PVP‐k30). Initially, MWCNT were chemically functionalized by acid treatment and nanocomposites (NCs) of PVP‐k30 and c‐MWCNT were formed and subsequently blended with PES polymer. The spectra of FTIR of the HD membranes revealed that NCs has strong hydrogen bonding and their addition to PES polymer improved the capillary system of membranes as confirmed by Field Emission Scanning Electron Microscope (FESEM) and leaching of the additive decreased to 2% and hydrophilicity improved to 22%. The pore size and porosity of NCs were also enhanced and rejection rate was achieved in the establish dialysis range (<60 kDa). The antifouling studies had shown that NCs membrane exhibited 30% less adhesion of protein with 80% flux recovery ratio. The blood compatibility assessment disclosed that NCs based membranes showed prolonged thrombin and prothrombin clotting times, lessened production of fibrinogen cluster, and greatly suppressed adhesion of blood plasma than a pristine PES membrane. The results also unveiled that PVP‐k30/NCs improved the surface properties of the membrane and the urea and creatinine removal increased to 72% and 75% than pure PES membranes. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 513–525, 2019.

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Section: Discussionmentioning

confidence: 99%

“…The M3 membrane showed the lowest hydrophobicity (see Fig. ) which explained for the low protein adsorption . Moreover, the total repulsive force of NCs reduced the protein adsorption and is dependent on the weight percentage quantity of NCs in the membrane matrix.…”

Section: Discussionmentioning

confidence: 99%

Fabrication and performance evaluation of blood compatible hemodialysis membrane using carboxylic multiwall carbon nanotubes and low molecular weight polyvinylpyrrolidone based nanocomposites

Irfan

Idris

et al. 2018

J Biomedical Materials Res

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“…Polyethersulfone (PES)‐based synthetic membranes have been widely applied in clinic for hemodialysis, plasmapheresis and plasma collection . However, due to large size and hydrophobic surface, the existing membranes always undergo biofouling, which will finally trigger thrombus generation . To improve anti‐biofouling and anti‐thrombosis effect of large‐sized membranes, many efforts have been made, e. g ., surface functionalization and surface modification .…”

Section: Introductionmentioning

confidence: 99%

“…[14] However, due to large size and hydrophobic surface, the existing membranes always undergo biofouling, which will finally trigger thrombus generation. [15,16] To improve antibiofouling and anti-thrombosis effect of large-sized membranes, many efforts have been made, e. g., surface functionalization and surface modification. [17] It is well known that the electrical neutrality and hydrophilic nature of modifying components can reduce electrostatic and nonpolar interactions between proteins and membrane surfaces.…”

Section: Introductionmentioning

confidence: 99%

Hydrophilic Porous Poly(l‐Lactic Acid) Nanomembranes: Self‐Assembly, and Anti‐Biofouling and Anti‐Thrombosis Effects

et al. 2019

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Hydrophilic PEGylated porous self‐assembled nanomembranes (PSANMs) with average thickness and pore diameter of ca. 10 and 20–24 nm were successfully prepared by an emulsification‐induced programmable self‐assembly strategy. The hydrophilicity, anti‐biofouling, and anti‐thrombosis properties of PEGylated PSANMs were largely improved in comparison with the nonfunctionalized PSANMs, which could transform into hydrophilic (PEGylated PSANMs, minimum water contact angle: 38.8°) from hydrophobic units (PSANMs, maximum water contact angle: 137.5°) with increasing PEG density and length. The total protein adsorption of PEGylated PSANMs was about six times lower than that of the PSANMs, while the thrombosis of the PEGylated PSANMs (maximum R‐time: 5.37 min) was also greatly relieved in comparison with the PSANMs (minimum R‐time: 2.93 min). Such PEG‐modified PSANMs may have applications in drug delivery and tissue and organ repair in vivo.

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“…In this study, polyethersulfone (PES) was chosen to be used as the main polymer due to its excellent mechanical and chemical properties, outstanding oxidative, thermal and hydrolytic properties. Furthermore, PES was notable to be used in biomedical field application for medical devices, artificial organs and also as a material for dialyzer membrane in blood purification applications such as hemodialysis, hemofiltration and plasmapheresis . POC was used as an additive of PES membranes through direct blending.…”

Section: Introductionmentioning

confidence: 99%

Hemocompatibility evaluation of poly(1,8‐octanediol citrate) blend polyethersulfone membranes

Zailani

Ismail

Kadir

et al. 2017

J Biomedical Materials Res

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In this study, poly (1,8-octanediol citrate) (POC) was used to modify polyethersulfone (PES)-based membrane to enhance its hemocompatibility. Different compositions of POC (0-3%) were added into the polyethersulfone (PES) dope solutions and polyvinylpyrrolidone (PVP) was used as pore forming agent. The hemocompatible POC modified PES membranes were fabricated through phase-inversion technique. The prepared membranes were characterized using attenuated total reflectance-Fourier transform infrared (ATR-FTIR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), Atomic-force microscopy (AFM), contact angle, Zeta-potential, membrane porosity and pore size and pure water flux (PWF) and BSA rejection. The hemocompatibility of the modified PES membranes was evaluated by human serum fibrinogen (FBG) protein adsorption, platelet adhesion, activated partial thromboplastin time (APTT) and prothrombin time (PT), and thrombin-antithrombin III (TAT), complement (C3a and C5a) activation and Ca absorption on membrane. Results showed that by increasing POC concentration, FBG adsorption was reduced, less platelets adhesion, prolonged APTT and PT, lower TAT, C5a and C3a activation and absorb more Ca ion. These results indicated that modification of PES with POC has rendered improved hemocompatibility properties for potential application in the field of blood purification, especially in hemodialysis. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1510-1520, 2017.

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Overview of PES biocompatible/hemodialysis membranes: PES–blood interactions and modification techniques

Cited by 121 publications

References 164 publications

Fabrication and performance evaluation of blood compatible hemodialysis membrane using carboxylic multiwall carbon nanotubes and low molecular weight polyvinylpyrrolidone based nanocomposites

Fabrication and performance evaluation of blood compatible hemodialysis membrane using carboxylic multiwall carbon nanotubes and low molecular weight polyvinylpyrrolidone based nanocomposites

Hydrophilic Porous Poly(l‐Lactic Acid) Nanomembranes: Self‐Assembly, and Anti‐Biofouling and Anti‐Thrombosis Effects

Hemocompatibility evaluation of poly(1,8‐octanediol citrate) blend polyethersulfone membranes

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