Overview of Plant-Derived Vaccine Antigens: Dengue Virus

Malabadi, Ravindra B.; Ganguly, Advaita; Silva, Jaime A. Teixeira da; Parashar, Archana; Suresh, Mavanur R.; Sunwoo, Hoon H.

doi:10.18433/j3401k

Cited by 17 publications

(15 citation statements)

References 126 publications

(255 reference statements)

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“…Essential oils are the complex volatile compounds, synthesized naturally in different plant parts during the process of secondary metabolism (Swamy et al, 2016;Teixeira et al, 2013). A wide variety of herbal plants are available in the Indian subcontinent, and they are the backbone of Indian traditional herbal medicinal system, Ayurveda and Siddha (Malabadi et al, 2021a;Kulkarni et al, 2020;Swamy et al, 2016;Malabadi, 2008;Malabadi and Vijayakumar, 2008;Malabadi et al, 2009Malabadi et al, , 2010aMalabadi et al, , 2010bMalabadi et al, , 2011aMalabadi et al, , 2011bMalabadi et al, 2012aMalabadi et al, , 2012bMalabadi et al, , 2012cMalabadi et al, , 2012dMalabadi et al, 2016aMalabadi et al, , 2016cMalabadi et al, , 2016dMalabadi et al, 2017aMalabadi et al, , 2017bMalabadi et al. 2018).…”

Section: Introductionmentioning

confidence: 99%

Role of botanical essential oils as a therapy for controlling coronavirus (SARS-CoV-2) disease (Covid-19)

Malabadi¹,

Kolkar²,

Meti³

et al. 2021

IJRSI

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This review paper presented on the basis of extensive literature survey updated the importance of plant essential oils in controlling many diseases, particularly coronavirus (SARS-CoV-2) disease outbreak. Plant essential oils are valuable natural products, and used as a raw materials in aromatherapy, phytotherapy, perfumery, cosmetics, spices and nutrition. Aromatic plants produced a diversity of chemical constituents with the potential to inhibit viral replication. Essential oils have several biological properties such as antibacterial, antifungal, antiviral, antioxidant, anti-inflammatory, wound-healing and anti-cancer effects in in vitro and in vivo. Therefore, essential oils have been analyzed and described as good antiviral agents against respiratory tract viral infections, hence are excellent prospective candidate against coronavirus. Thus, essential oils and their constituents can hopefully be considered in near future for more clinical assessment and possible applications in controlling the coronavirus pandemic. However, some of the plant essential oils are very toxic and poisonous and therefore, oral consumption should be avoided. Further detailed clinical trial experiments should be conducted for the scientific validation.

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Section: Introductionmentioning

confidence: 99%

Role of botanical essential oils as a therapy for controlling coronavirus (SARS-CoV-2) disease (Covid-19)

Malabadi¹,

Kolkar²,

Meti³

et al. 2021

IJRSI

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“…This feature has made vaccine development efforts against the dengue virus a difficult issue. Nevertheless, researchers around the world are exploring different approaches towards dengue vaccine development based on recombinant viral proteins expressed in different systems, inactivated viruses, conventional live attenuated viruses, antigen encoding plasmids and viral vectors encoding antigen genes (3).…”

Section: Introductionmentioning

confidence: 99%

Enhanced Prokaryotic Expression of Dengue Virus Envelope Protein

et al. 2013

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Purpose. To highlight the expression and purification of the recombinant dengue virus type-1 antigen exploiting the codon optimized full length envelope for increased yield in E. coli. Methods. A 6x His tag was inserted at the C terminus to facilitate purification. The purified protein was recognized in Western blot by Monoclonal antibody specific for the tag. The in vitro refolded recombinant protein was used to immunize mice for the development of hybridomas and also analyzed for its biological functionality with heparan sulfate binding assay. Results. The polyclonal anti-sera from the immunized mice were found to recognize the envelope protein thereby establishing the immunogenicity of the protein. Conclusion. The purified envelope protein could potentially be used towards dengue diagnostics and vaccine development efforts. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

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“…The immature stages of Aedes aegypti mosquito are found in water-filled habitats, mostly in artificial containers closely associated with human dwellings and often indoors. This means that people, rather than mosquitoes, rapidly move the virus within and between communities and places World Health Organisation (WHO) [4,5,2,3]. Dengue disease continues to involve newer areas, newer populations and is increasing in magnitude, epidemic after epidemic.…”

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confidence: 99%

“…Dengue disease continues to involve newer areas, newer populations and is increasing in magnitude, epidemic after epidemic. Every aspect of dengue viral infection continues to be a challenge; the pathogenesis of severe dengue disease is not known, no vaccine is yet available for protection and the vector control measures are inadequate World Health Organisation (WHO) [6,7,8,9,10,11,4,5,2,3]. Search for new anti-dengue agents from medicinal plants has assumed more urgency than in the past.…”

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confidence: 99%

“…Medicinal plants have been used widely to treat a variety of vector World Health Organisation (WHO), [4,5,2,3]. The larvicidal activity of hydrodistillate extracts from Mentha piperita L. Ocimum basilicum L. Curcuma longa L. and Zingiber officinale L. Cymbopogon citrates L. Lippi asidoides L. Ocimum americanum L. Ocimum gratissimum L. were investigated against the dengue vector Aedes aegypti L. (Diptera: Culicidae).…”

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2019

RJLBPCS

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Mosquito borne diseases such as dengue, ebola, zika, chikungunya, malaria and filariasis etc. pose a serious threat worldwide in terms of public health. They are responsible for a significant economic burden for the African and Asian continent. Development of resistance, cross-resistance, rising cost and possible toxicity hazards associated with synthetic insecticides are some of the reasons for revival of interest in plant-based products in recent years. Search for cost-effective, safe and highly potent plant-based insecticides for the control of mosquitoes requires the preliminary screening of plants to evaluate their effectiveness in mosquito control and selecting the plants with high potency for further study. Essential oil of Psidium guajava L.variety Navalur Light pink was studied for its chemical composition and larvicidal potential against Aedes aegypti larve. Totally 84.33%compounds were identified in species by GC-MS (Gas Chromatography-Mass Spectrometry). The major chemical compounds were 1-(1-Ethylvinyl)-1-(-2methylene-3-butenyl) cycloproane of 53.34% in Navalur Light. Preliminary bioassay test was carried out by using modified WHO method for determination of larvicidal activity against Aedes aegypti larve. Essential oils of Psidium guajava extract showed good mortality rate in Aedes larvae. Experimental results suggest that essential oil of Psidium guajava species are one of the inexpensive and eco friendly sources of natural mosquito larvicidal agent to control or to reduce the population of Aedes aegypti mosquito. Further isolation and identification of active ingredients in essential oil of Psidium guajava are under process.

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Overview of Plant-Derived Vaccine Antigens: Dengue Virus

Cited by 17 publications

References 126 publications

Role of botanical essential oils as a therapy for controlling coronavirus (SARS-CoV-2) disease (Covid-19)

Role of botanical essential oils as a therapy for controlling coronavirus (SARS-CoV-2) disease (Covid-19)

Enhanced Prokaryotic Expression of Dengue Virus Envelope Protein

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