2022
DOI: 10.3390/cells11010164
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Overview of Polyamines as Nutrients for Human Healthy Long Life and Effect of Increased Polyamine Intake on DNA Methylation

Abstract: Polyamines, spermidine and spermine, are synthesized in every living cell and are therefore contained in foods, especially in those that are thought to contribute to health and longevity. They have many physiological activities similar to those of antioxidant and anti-inflammatory substances such as polyphenols. These include antioxidant and anti-inflammatory properties, cell and gene protection, and autophagy activation. We have first reported that increased polyamine intake (spermidine much more so than sper… Show more

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Cited by 41 publications
(54 citation statements)
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References 296 publications
(455 reference statements)
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“…In addition, antizymes are able to inhibit the absorption of polyamines or stimulate their secretion. The existence of 3 forms of AZI antizymes has been shown: AZI 1, AZI 2, and AZI 3 [ 21 ]. A more complex regulation of ODC activity is provided by antizyme inhibitor (AZIN) proteins, which are able to interact with AZI with a higher affinity than with ODC.…”
Section: Polyamine Metabolism In Normal Mammalsmentioning
confidence: 99%
See 4 more Smart Citations
“…In addition, antizymes are able to inhibit the absorption of polyamines or stimulate their secretion. The existence of 3 forms of AZI antizymes has been shown: AZI 1, AZI 2, and AZI 3 [ 21 ]. A more complex regulation of ODC activity is provided by antizyme inhibitor (AZIN) proteins, which are able to interact with AZI with a higher affinity than with ODC.…”
Section: Polyamine Metabolism In Normal Mammalsmentioning
confidence: 99%
“…A more complex regulation of ODC activity is provided by antizyme inhibitor (AZIN) proteins, which are able to interact with AZI with a higher affinity than with ODC. Currently, two forms have been identified: AZIN 1 and AZIN 2 [ 21 ].…”
Section: Polyamine Metabolism In Normal Mammalsmentioning
confidence: 99%
See 3 more Smart Citations