Overview of preparation methods of polymeric and lipid-based (niosome, solid lipid, liposome) nanoparticles: A comprehensive review

Amoabediny, Ghassem; Haghiralsadat, Fateme; Naderinezhad, Samira; Helder, Marco N.; Kharanaghi, Elham Akhoundi; Arough, Javad Mohammadnejad; Zandieh-Doulabi, Behrouz

doi:10.1080/00914037.2017.1332623

Cited by 184 publications

(92 citation statements)

References 136 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Then, the entrapment e ciency was determined by a UV/VIS spectrophotometer (Beckman, DU 530, Switzerland) at a wavelength of 270 nm. Finally, the essential oil concentration entrapped in nanoliposomes was calculated using the following formula (17):…”

Section: Entrapment E Ciencymentioning

confidence: 99%

Lavandula Angustifolia Essential Oil Loaded in Liposomal Nano-Carriers Regulate the HER2 and CASP3 Genes in MCF-7 and SK-BR-3 Cell-Lines

Mohammadpanah

Mojodi

Haghiralsadat

et al. 2020

Preprint

View full text Add to dashboard Cite

Abstract Cancer drug delivery has recently focused on using novel carrier systems due to their high drug-loading capacity, release rate properties, and minimum side effects. Finding novel chemotherapeutic agents would be essential for the improvement of integrated treatment planning. In this study, the effect of constructed nano-liposomal particles of Lavandula angustifolia essential oil (LAEO) was evaluated on cell toxicity and the expression of HER-2 and Caspase-3 genes in two MCF-7 and SK-BR-3 cell lines. Our results showed a high entrapment efficiency (50 ± 3.34), and a low average size (68.3 ± 7.28 nm) of nano-liposomes under suitable conditions. The surface charge of particles was at a range of -2 to -4.5 mV. The release rate of nanoparticles was estimated to be 63.98% (37 °C; pH = 7) and 87.63% (42 °C; pH = 5) in MCF-7 and SK-BR-3 cell lines after 48 hours, respectively. The stability of nanoparticles without a great increase in particle sizes and spherical shape was observed using force atomic microscopy. The degree of cell growth in response to nanoliposomal LAEO was significantly decreased in comparison with free essential oil (p-value < 0.01) when assayed on both cell lines. The analysis of gene expression showed that the treatment of cancer cell lines with nanoliposomal LAEO significantly elevated the relative expression of the caspase-3 gene while reducing the expression of HER-2 (P < 0.05). Based on the obtained results, it seems that LAEO in the form of nanoparticles could have more efficiency on the growth inhibition of cancer cell lines in comparison with the free form of the essential oil. Further studies are required to assess the in vivo effects of LAEO nanoliposomes with refined formulations against various types of cancer (Fig. 1).

show abstract

Section: Entrapment E Ciencymentioning

confidence: 99%

Lavandula Angustifolia Essential Oil Loaded in Liposomal Nano-Carriers Regulate the HER2 and CASP3 Genes in MCF-7 and SK-BR-3 Cell-Lines

Mohammadpanah

Mojodi

Haghiralsadat

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Their selection depends primarily on the route of application. Generally, SLNs are prepared by a solid lipid from which the drug is dissolved or diffused [4].…”

Section: Introductionmentioning

confidence: 99%

SOLID LIPID NANOPARTICLES (SLNs) AS NANO DRUG DELIVERY CARRIERS: PREPARATION, CHARACTERIZATION AND APPLICATION

Qushawy

Nasr

2019

Int J App Pharm

View full text Add to dashboard Cite

Over the last few years, there has been a significant consideration of solid lipid nanoparticles (SLNs) as an alternative method to other colloidal dispersion methods for drug delivery. Special consideration has been given to the use of SLNs as a drug carrier in recent years. SLNs are aqueous dispersions in which the colloidal particles consist of solid lipids that are biodegradable. As a result of their physical stability, the protection of the entrapped drug from decomposition, the provision of controlled drug release, and the exceptional acceptability, SLNs have several advantages over other drug carriers. This article focuses on the techniques of SLNs preparation and characterization, the effect of formulation variables on SLNs properties, the routes of administration, and the pharmaceutical applications. The data used for this review was collected by searching on Google Scholar and PubMed using the following keywords during the period from 2010 to date.

show abstract

“…Methods to create high surface area nanostructures include laser ionization, [7] chemical and photo lithography [8] and fabrication of nanosize particles. [9] In general, complex and expensive technologies are required and limit the wider applications of these materials. To avoid costly equipment, complicated procedures and high energy consumption, alternative methods for assembling high surface area nanostructured materials are explored.…”

Section: Introductionmentioning

confidence: 99%

Morphology Tuneable and Multifunctional Polystyrene‐Silicone Nano‐Composite Materials

Zhang

Seeger

2019

ChemNanoMat

View full text Add to dashboard Cite

Nanostructured materials have shown extraordinary promise for high surface area applications. Here we report the design of polystyrene (PS)‐silicone nanofilaments (SNFs) composites, which can be flexibly grown on various substrates. The high surface area achieved by the SNFs is further extended by grafting with polystyrene. By changing the polymerization conditions and post treatment methods, the morphology of grafted PS is easily tuned into three types: leaf‐shaped, bead‐shaped and well‐wrapped. The tuneable morphology of PS is optimized for oil‐water separation and photocatalytic reactions and exhibited improved performances.

show abstract

Overview of preparation methods of polymeric and lipid-based (niosome, solid lipid, liposome) nanoparticles: A comprehensive review

Cited by 184 publications

References 136 publications

Lavandula Angustifolia Essential Oil Loaded in Liposomal Nano-Carriers Regulate the HER2 and CASP3 Genes in MCF-7 and SK-BR-3 Cell-Lines

Lavandula Angustifolia Essential Oil Loaded in Liposomal Nano-Carriers Regulate the HER2 and CASP3 Genes in MCF-7 and SK-BR-3 Cell-Lines

SOLID LIPID NANOPARTICLES (SLNs) AS NANO DRUG DELIVERY CARRIERS: PREPARATION, CHARACTERIZATION AND APPLICATION

Morphology Tuneable and Multifunctional Polystyrene‐Silicone Nano‐Composite Materials

Contact Info

Product

Resources

About