Overview of recent developments of pyrazole derivatives as an anticancer agent in different cell line

Bennani, Fatima Ezzahra; Doudach, Latifa; Cherrah, Yahia; Ramli, Youssef; Karrouchi, Khalid; Ansar, Mʼhammed; Faouzi, My El Abbes

doi:10.1016/j.bioorg.2019.103470

Cited by 209 publications

(107 citation statements)

References 109 publications

Supporting

Mentioning

106

Contrasting

Unclassified

Order By: Relevance

“…In light of this review, promising cytotoxic activities of some analogs against breast cancer cell lines (MCF-7 and MDA-MB-231) is expected to stimulate extensive evaluation of their effects on lung cancer (A-549), liver cancer (HepG-2), and brain cancer (HeLa) cell lines (Lv et al, 2016;Lehmann et al, 2017;Turkan et al, 2018;McKenzie et al, 2019;Bennani et al, 2020;Masaret, 2021). As a life-threatening health issue and one of the most lethal diseases known, cancer can be managed by targeting gene expression, certain protein synthesis, functions of organelles, pH, and electrolytes (Johnston and Strobel, 2020).…”

Section: Final Considerations and Future Perspectivementioning

confidence: 99%

Heterocyclic Compounds: Pharmacology of Pyrazole Analogs From Rational Structural Considerations

et al. 2021

View full text Add to dashboard Cite

Low quality of life and life-threatening conditions often demand pharmacological screening of lead compounds. A spectrum of pharmacological activities has been attributed to pyrazole analogs. The substitution, replacement, or removal of functional groups on a pyrazole ring appears consistent with diverse molecular interactions, efficacy, and potency of these analogs. This mini-review explores cytotoxic, cytoprotective, antinociceptive, anti-inflammatory, and antidepressant activities of some pyrazole analogs to advance structure-related pharmacological profiles and rational design of new analogs. Numerous interactions of these derivatives at their targets could impact future research considerations and prospects while offering opportunities for optimizing therapeutic activity with fewer adverse effects.

show abstract

Section: Final Considerations and Future Perspectivementioning

confidence: 99%

Heterocyclic Compounds: Pharmacology of Pyrazole Analogs From Rational Structural Considerations

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Most of the synthesized pyrazole derivatives have been studied for their in vitro antiproliferative activities and in vivo antitumor activity, often resulting in promising lead scaffolds [ 81 , 82 , 83 , 84 , 85 ]. Recently, Bennani et al also demonstrated that pyrazole derivatives possess high antiproliferative activity against tumors cells such as breast (MCF-7), lung (A-549), liver (HepG-2), and brain (HeLa) cell lines [ 86 ]. In a continuing interest in pyrazole-based derivatives, PTs with pyrazole rings have been reported.…”

Section: Pyrazolementioning

confidence: 99%

Pentacyclic Triterpenoids with Nitrogen-Containing Heterocyclic Moiety, Privileged Hybrids in Anticancer Drug Discovery

et al. 2021

View full text Add to dashboard Cite

Pentacyclic triterpenoids are well-known phytochemicals with various biological activities commonly found in plants as secondary metabolites. The wide range of biological activities exhibited by triterpenoids has made them the most valuable sources of pharmacological agents. A number of novel triterpenoid derivatives with many skeletal modifications have been developed. The most important modifications are the formation of analogues or derivatives with nitrogen-containing heterocyclic scaffolds. The derivatives with nitrogen-containing heterocyclic compounds are among the most promising candidate for the development of novel therapeutic drugs. About 75% of FDA-approved drugs are nitrogen-containing heterocyclic moieties. The unique properties of heterocyclic compounds have encouraged many researchers to develop new triterpenoid analogous with pharmacological activities. In this review, we discuss recent advances of nitrogen-containing heterocyclic triterpenoids as potential therapeutic agents. This comprehensive review will assist medicinal chemists to understand new strategies that can result in the development of compounds with potential therapeutic efficacy.

show abstract

“…Azole nuclei, which are exemplified by 1,2,3‐triazole, 1,2,4‐triazole, tetrazole, pyrazole, imidazole, thiazole, and oxazole, have proven to be an unusually fertile source of medicinal agents. [ 48,49 ] Azole derivatives could exhibit the antibacterial activities via diverse mechanisms of action such as inhibition of DNA gyrase, topoisomerase IV, and efflux pumps, and they possess promising antibacterial activities against both drug‐sensitive and ‐resistant pathogens. [ 6,50 ] Moreover, several azole‐based drugs such as cefazolin, cloxacillin, linezolid, and tedizolid have already been used in clinics for the treatment of various bacterial infections, even those caused by drug‐resistant pathogens.…”

Section: Indole/isatin–azole Hybridsmentioning

confidence: 99%

Indole/isatin‐containing hybrids as potential antibacterial agents

Song

Bian

et al. 2020

Archiv der Pharmazie

View full text Add to dashboard Cite

The emergence and worldwide spread of drug-resistant bacteria have already posed a serious threat to human life, creating the urgent need to develop potent and novel antibacterial drug candidates with high efficacy. Indole and isatin (indole-2,3-dione) present a wide structural and mechanistic diversity, so their derivatives possess various pharmacological properties and occupy a salient place in the development of new drugs. Indole/isatin-containing hybrids, which demonstrate a promising activity against a panel of clinically important Gram-positive and Gram-negative bacteria, are privileged scaffolds for the discovery of novel antibacterial candidates. This review, covering articles published between January 2015 and May 2020, focuses on the development and structure-activity relationship (SAR) of indole/isatincontaining hybrids with potential application for fighting bacterial infections, to facilitate further rational design of novel drug candidates.

show abstract

Overview of recent developments of pyrazole derivatives as an anticancer agent in different cell line

Cited by 209 publications

References 109 publications

Heterocyclic Compounds: Pharmacology of Pyrazole Analogs From Rational Structural Considerations

Heterocyclic Compounds: Pharmacology of Pyrazole Analogs From Rational Structural Considerations

Pentacyclic Triterpenoids with Nitrogen-Containing Heterocyclic Moiety, Privileged Hybrids in Anticancer Drug Discovery

Indole/isatin‐containing hybrids as potential antibacterial agents

Contact Info

Product

Resources

About