2007
DOI: 10.1002/0471140864.ps1808s50
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Overview of Solid Phase Synthesis of “Difficult Peptide” Sequences

Abstract: Solid-phase peptide synthesis has contributed immeasurably to the understanding of the chemistry and biology of peptides by enabling their ready preparation in small quantities up to the ton scale. The advantages of the technology, including its simplicity, ease of operation, and general efficiency have far outweighed its limitations. However, despite the general effectiveness of the solid phase synthesis methodology, some peptides are resistant to efficient assembly and are known as "difficult peptides." Such… Show more

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Cited by 35 publications
(39 citation statements)
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“…Successful peptide synthesis is known to technically depend on its length or amino acid sequence (23). Because of the technical difficulty associated with synthesizing the full-length SAA3 peptide without the signal sequence (103 mer), we attempted to shorten the SAA3 peptide sequence while retaining its biological activity.…”
Section: Resultsmentioning
confidence: 99%
“…Successful peptide synthesis is known to technically depend on its length or amino acid sequence (23). Because of the technical difficulty associated with synthesizing the full-length SAA3 peptide without the signal sequence (103 mer), we attempted to shorten the SAA3 peptide sequence while retaining its biological activity.…”
Section: Resultsmentioning
confidence: 99%
“…Since Merrifield invented the technology in 1963, SPPS has become the primary approach for the routine preparation of peptides [28][29][30][31][32]. The general scheme of solid phase peptide synthesis is illustrated in Fig.…”
Section: Synthesis Of Peptide Fragmentsmentioning
confidence: 99%
“…[86] Recombinant expression of this protein is limited due to the high number of hydroxyproline residues.…”
Section: Native Chemical Ligationmentioning
confidence: 99%