Overview of the coagulation system

Palta, Sanjeev; Saroa, Richa; Palta, Anshu

doi:10.4103/0019-5049.144643

Cited by 712 publications

(643 citation statements)

References 39 publications

Supporting

Mentioning

617

Contrasting

Unclassified

Order By: Relevance

“…Basic coagulation tests were performed for initial characterization of intrinsic and extrinsic pathways of the coagulation system [29] and for detection of overall procoagulant potential of haemostasis [30]. Normally, determination of these parameters is insufficient to characterize the haemostasis system and several additional tests are needed [31].…”

Section: Resultsmentioning

confidence: 99%

Blood coagulation and aortic wall integrity in rats with obesity-induced insulin resistance

Dziuba¹

2018

Ukr.Biochem.J

View full text Add to dashboard Cite

Obesity is an important factor in pathogenesis of disorders caused by chronic inflammation. Diet-induced obesity leads to dyslipidemia and insulin resistance (Ir) O besity is recognized as an important factor in the pathogenesis of metabolic disorders. Metabolic syndrome which is related to weight gain, specifically intra-abdominal fat accumulation, is a known risk factor for early cardiovascular diseases. The reason for such a dependence is clear from the other name for the metabolic syndrome; it is also known as 'the deadly quartet'

show abstract

Section: Resultsmentioning

confidence: 99%

Blood coagulation and aortic wall integrity in rats with obesity-induced insulin resistance

Dziuba¹

2018

Ukr.Biochem.J

View full text Add to dashboard Cite

show abstract

“…El término proviene de hema (sangre) y estasis (parar), y se refiere al equilibrio trombohemorrágico que se mantiene por interacciones entre la coagulación, el sistema fibrinolítico, las plaquetas y la pared vascular 25 . La activación de la coagulación requiere la participación de plaquetas, endotelio, monocitos y factores de coagulación, y puede ocurrir por las vías extrínseca, intrínseca o ambas, englobadas en el modelo celular de la coagulación 26 .…”

Section: La Hemostasia En El Cáncer Colorrectal Y El Pronósticounclassified

Angiogénesis y hemostasia en cáncer colorrectal

Agredano-Pérez¹,

Mariscal-Ramírez²,

Ronquillo-Carreón³

et al. 2022

GAMO

View full text Add to dashboard Cite

Resumen Mundialmente, el cáncer colorrectal representa la tercera causa de muerte en hombres y la segunda causa de muerte en mujeres, con cerca de 1.2 millones de casos nuevos diagnosticados y 600,000 muertes estimadas. Una proporción importante de pacientes son diagnosticados con enfermedad metastásica al momento del diagnóstico. La neoangiogénesis es la formación de nuevos vasos sanguíneos a partir de los existentes, los cuales juegan un papel importante en la progresión y crecimiento tumoral. Se han identificado factores relacionados con el crecimiento endotelial, entre ellos el factor de crecimiento endotelial vascular. Diversos estudios han demostrado la participación en el desarrollo angiogénico tumoral de la activación de los sistemas de la coagulación y fibrinólisis. Algunos de estos factores son el factor von Willebrand, el fibrinógeno, el activador del plasminógeno de tipo I, su inhibidor y su receptor, además del dímero D y las plaquetas. Se considera que las concentraciones séricas de estas proteínas son factores predictivos de respuesta al tratamiento, progresión de la enfermedad y superviviencia. La interacción entre las células tumorales, la angiogénesis y la activación de la coagulación es una retroalimentación positiva. Las estrategias que interfieran en esta relación pueden prevenir o tratar el cáncer, como el uso de quimioterapia en combinación con nuevos agentes específicos de diana. Además, el papel de los anticoagulantes o antiplaquetarios en el tratamiento del cán-cer aún no se ha determinado. (creativecommons.org/licenses/by-nc-nd/4.0/). Abstract Worldwide, colorectal cancer is the third cause of death in men and the second leading cause of death in women, with about 1.2 million new cases diagnosed and 600,000 estimated deaths. A significant proportion of patients are diagnosed with metastatic disease at diagnosis. Angiogenesis is the formation of new blood vessels from existing ones, which play an important role in tumor growth and progression. Factors related to endothelial growth, including vascular endothelial growth factor, have been identified. Several studies have shown the PALABRAS CLAVEAngiogénesis; Cáncer colorrectal; Estado protrombótico; Pronóstico; Trombosis; Factor de crecimiento endotelial vascular (VEGF)

show abstract

“…Factor VIIa is generated after a cleavage of a single peptide in the protease domain of FVII from a different coagulation enzymes, such as FXa, FIXa, and FVIIa itself. However, FXa seems to be the main activator of FVIIa [6]. It has been shown that the binding of FVII to TF increases its activity by several folds.…”

Section: Coagulation Cascade: Something New?mentioning

confidence: 99%

“…Two different initiator pathways were linked to this model: 1) the "intrinsic pathway, " in which all the clotting factors were present in blood starting from the conversion of FXII to FXIIa induced by the contact to polyanions secreted by activated platelets, and 2) the "extrinsic pathway", in which the subendothelial thrombogenic material, such as TF, was required in addition to circulating components. Both of them resulted in activation of FX and the formation of a fibrin-rich clot through a common pathway [6].…”

Section: Coagulation Cascade: Something New?mentioning

confidence: 99%

The Two Faces of Thrombosis: Coagulation Cascade and Platelet Aggregation. Are Platelets the Main Therapeutic Target?

Cimmino¹,

Fischetti²,

Golino³

2017

J Thrombo Cir

View full text Add to dashboard Cite

Acute thrombus formation is the pathophysiological substrate underlying several clinical conditions, such as acute coronary syndrome (ACS) and stroke. Activation of coagulation cascade is a key step of the thrombotic process: vessel injury results in exposure of the glycoprotein tissue factor (TF) to the flowing blood. Once exposed, TF binds factor VII/VIIa (FVII/FVIIa) and in presence of calcium ions, it forms a tertiary complex able to activate FX to FXa, FIX to FIXa, and FVIIa itself. The final step is thrombin formation at the site of vessel injury with subsequent platelet activation, fibrinogen to fibrin conversion and ultimately thrombus formation.Platelets are the key cells in primary hemostasis. For years they have been considered only as cell fragments participating to primary hemostasis and onto which coagulation factors are assembled in the process of thrombus formation. However, recent advances in platelets pathophysiology have shown that these cells are able to regulate their gene and protein expression, make de novo protein synthesis, and release different mediators with paracrine effects that may interfere with different cell functions.Pharmacological modulation of both side of thrombosis, coagulation cascade and platelet activation, is of great clinical importance. Several clinical trials have clearly shown the efficacy of anticoagulation and/or anti platelet aggregation in different thrombotic disorders. This article aims at reviewing the recent advancements on the two faces of thrombosis focusing on the emerging role of platelets not only as clot-forming components, but highlighting their involvement in the inflammatory-immune system, as well as in modulation of different cell functions.

show abstract

Overview of the coagulation system

Cited by 712 publications

References 39 publications

Blood coagulation and aortic wall integrity in rats with obesity-induced insulin resistance

Blood coagulation and aortic wall integrity in rats with obesity-induced insulin resistance

Angiogénesis y hemostasia en cáncer colorrectal

The Two Faces of Thrombosis: Coagulation Cascade and Platelet Aggregation. Are Platelets the Main Therapeutic Target?

Contact Info

Product

Resources

About