Overview of the role and action mechanism of microRNA-128 in viral infections

Alshahrani, Shadia Hamoud; Alameri, Ameer A.; semarang, Fitriani kahar poltekkes kemenkes; Ramírez‐Coronel, Andrés Alexis; Obaid, Rasha Fadhel; Alsaikhan, Fahad; Zabibah, Rahman S.; Qasim, Qutaiba A.; Altalbawy, Farag M. A.; Mustafa, Yasser Fakri; Mirzaei, Rasoul; Karampoor, Sajad

doi:10.1016/j.micpath.2023.106020

Cited by 3 publications

(2 citation statements)

References 146 publications

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“…Cellular miRNAs can exert anti- or proviral effects and they are often dysregulated upon viral infections [ 8 , 9 ]. For example, miRNA-128 limits the replication and dissemination of the human immunodeficiency virus type 1 (HIV-1), whereas miRNA-34 promotes HIV-1 pathogenesis by inducing the accelerated decay of host proteins influencing the HIV-1 life cycle [ 10 , 11 ]. Virus infections have also been shown to induce post-transcriptional modifications on host genes’ transcripts.…”

Section: Introductionmentioning

confidence: 99%

IGF2BP1—An Oncofetal RNA-Binding Protein Fuels Tumor Virus Propagation

Glaß

Hüttelmaier

2023

Viruses

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The oncofetal RNA-binding protein IGF2BP1 has been reported to be a driver of tumor progression in a multitude of cancer entities. Its main function is the stabilization of target transcripts by shielding these from miRNA-mediated degradation. However, there is growing evidence that several virus species recruit IGF2BP1 to promote their propagation. In particular, tumor-promoting viruses, such as hepatitis B/C and human papillomaviruses, benefit from IGF2BP1. Moreover, recent evidence suggests that non-oncogenic viruses, such as SARS-CoV-2, also take advantage of IGF2BP1. The only virus inhibited by IGF2BP1 reported to date is HIV-1. This review summarizes the current knowledge about the interactions between IGF2BP1 and different virus species. It further recapitulates several findings by presenting analyses from publicly available high-throughput datasets.

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Section: Introductionmentioning

confidence: 99%

IGF2BP1—An Oncofetal RNA-Binding Protein Fuels Tumor Virus Propagation

Glaß

Hüttelmaier

2023

Viruses

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“…Dysregulation of miR-128 has been connected to various cancers, including breast, lung, thyroid, head and neck, osteosarcoma, glioma or leukemia, and multiple myeloma (reviewed in [25]). Similarly, miR-128 has also been implicated in mental and behavioral disorders [26], viral infections [27], musculoskeletal disorders [28], or regulation of energy expenditure and metabolic disorders [29], among others. The physiological role of miR-128 in the brain is underlined by the clinical findings of aberrant miR-128 expression in neurodegenerative diseases such as Alzheimer's disease, Huntington's disease, or Parkinson's disease (reviewed in [30]).…”

Section: Introductionmentioning

confidence: 99%

Identification of miR-128 Target mRNAs That Are Expressed in B Cells Using a Modified Dual Luciferase Vector

Schreiber,

Daum,

Danzer

et al. 2023

Biomolecules

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MicroRNAs (miRNAs) are 21–25 nucleotide long non-coding ribonucleic acids that modulate gene expression by degrading transcripts or inhibiting translation. The miRNA miR-128, originally thought to be brain-specific, was later also found in immune cells. To identify a valuable immune cell model system to modulate endogenous miR-128 amounts and to validate predicted miR-128 target mRNAs in B cells, we first investigated miR-128 expression using Northern blot analysis in several cell lines representing different stages of B cell development. The results showed that only primary brain cells showed significant levels of mature miR-128. To study the function of miR-128 in immune cells, we modified dual luciferase vectors to allow easy transfer of 3′ UTR fragments with predicted miR-128 binding sites from widely used single to dual luciferase vectors. Comparison of in silico predicted miR-128-regulated mRNAs in single and dual luciferase constructs yielded similar results, validating the dual luciferase vector for miRNA target analysis. Furthermore, we confirmed miR-128-regulated mRNAs identified in silico and in vivo using the Ago HITS-CLIP technique and known to be expressed in B cells using the dual luciferase assay. In conclusion, this study provides new insights into the expression and function of miR-128 by validating novel target mRNAs expressed in B cells and identifying additional pathways likely controlled by this miRNA in the immune system.

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miRNA-Mediated Mechanisms in the Generation of Effective and Safe Oncolytic Viruses

Toropko,

Chuvpilo,

Karabelsky

2024

Pharmaceutics

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MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression by inhibiting the translation of target transcripts. The expression profiles of miRNAs vary in different tissues and change with the development of diseases, including cancer. This feature has begun to be used for the modification of oncolytic viruses (OVs) in order to increase their selectivity and efficacy. OVs represent a relatively new class of anticancer drugs; they are designed to replicate in cancer tumors and destroy them. These can be natural viruses that can replicate within cancer tumor cells, or recombinant viruses created in laboratories. There are some concerns regarding OVs’ toxicity, due to their ability to partially replicate in healthy tissues. In addition, lytic and immunological responses upon OV therapy are not always sufficient, so various OV editing methods are used. This review discusses the latest results of preclinical and clinical studies of OVs, modifications of which are associated with the miRNA-mediated mechanism of gene silencing.

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Overview of the role and action mechanism of microRNA-128 in viral infections

Cited by 3 publications

References 146 publications

IGF2BP1—An Oncofetal RNA-Binding Protein Fuels Tumor Virus Propagation

IGF2BP1—An Oncofetal RNA-Binding Protein Fuels Tumor Virus Propagation

Identification of miR-128 Target mRNAs That Are Expressed in B Cells Using a Modified Dual Luciferase Vector

miRNA-Mediated Mechanisms in the Generation of Effective and Safe Oncolytic Viruses

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