2013
DOI: 10.3923/pjbs.2013.1849.1861
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Overview on Cysteine Protease Inhibitors as Chemotherapy for Schistosomiasis mansoni in Mice and also its Effect on the Parasitological and Immunological Profile

Abstract: The present study evaluated the use of 3 types of Cysteine Protease Inhibitors (CPIs) with praziquantel (PZQ) as chemotherapy against schistosomiasis mansoni in mice. All groups were going to assessment of fluromethylketone (FMK), Vinyl Sulfone (VS) and Sodium Nitro Prussid (SNP) by measurement of parasitological, immunological and histological parameters. In our study, The ova count/gm liver or intestine on with PZQ treatment showed 99.1 and 95.2% Percent Reduction (PR), respectively compared to control group… Show more

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Cited by 12 publications
(4 citation statements)
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“…Also, histopathological scoring of liver (Table 3) and kidney (Table 4) sections was performed according to Ansari et al [34], Farid et al [35] and Khalid et al [36], respectively.…”
Section: Histological and Immunohistochemical Studiesmentioning
confidence: 99%
“…Also, histopathological scoring of liver (Table 3) and kidney (Table 4) sections was performed according to Ansari et al [34], Farid et al [35] and Khalid et al [36], respectively.…”
Section: Histological and Immunohistochemical Studiesmentioning
confidence: 99%
“…mansoni infection have shown to prevent growth and differentiation of the parasite. Among the CPIs, the best schistosomicidal effect was observed with FMK followed by VS to selectively arrest parasite replication [ 61 ]. Using docking protocol ( S3 Table ), we have shown that FMK (Mu-Y-(O-methyl)-hF-FMK) exhibit more negative interaction energy and lower inhibition constant as compared to K11777 (VS), suggesting FMK as better peptide inhibitors against SmCL1.…”
Section: Resultsmentioning
confidence: 99%
“…The specimens were then arranged in blocks and immersed in paraffin wax at 58 °C. For histological analysis, paraffin slices of 4 micron thickness were cut, stained with hematoxylin and eosin, mounted in dibutylphthalate polystyrene xylene, and then covered 33 , 35 . For immunohistochemical examination 28 , H 2 O 2 (3%) [followed by a PBS wash and a 60-min blocking with bovine serum albumin (BSA, 5%)] was used to inhibit the endogenous peroxidase activity.…”
Section: Methodsmentioning
confidence: 99%