Overweight and obesity as protective factors against mortality in nonischemic cardiomyopathy patients with an implantable cardioverter defibrillator

Zhou, Bin; Zhao, Shuang; Tang, Min; Chen, Keping; Hua, Wei; Su, Yangang; Chen, Silin; Liang, Zhaoguang; Xu, Wei; Li, Xiaoyao; Xue, Xiaodi; Sun, Xuerong; Zhang, Shu

doi:10.1002/clc.23458

Cited by 5 publications

(7 citation statements)

References 29 publications

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“…Braun et al [ 50 ] found that in 763 patients, the 64 obese patients (BMI > 30 kg/m 2 ) had a significantly lower 6-year all-cause mortality compared with normal-weight patients (BMI 18.5-25 kg/m 2 ). Other studies also report similar results[ 22 - 24 ], supporting the present study. Nevertheless, some points still remain to be clarified.…”

Section: Discussionsupporting

confidence: 93%

“…In a cohort study of 110000 Japanese adults, BMI (≥ 25 kg/m 2 ) had a protective effect on pneumonia mortality [odds ratio (OR) = 0.7, 95% confidence interval (CI): 0.5-0.8][ 21 ]. Thus, in some diseases, obesity has emerged as a protective factor that could improve prognosis and reduce mortality[ 22 - 24 ]. Nevertheless, conflicting results are found in the literature[ 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

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Influence of overweight and obesity on the mortality of hospitalized patients with community-acquired pneumonia

Wang¹,

Liu²,

Ma³

et al. 2022

WJCC

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BACKGROUND Obesity is associated with a better prognosis in patients with community-acquired pneumonia (the so-called obesity survival paradox), but conflicting results have been found. AIM To investigate the relationship between all-cause mortality and body mass index in patients with community-acquired pneumonia. METHODS This retrospective study included patients with community-acquired pneumonia hospitalized in the First Hospital of Qinhuangdao from June 2013 to November 2018. The patients were grouped as underweight (< 18.5 kg/m 2 ), normal weight (18.5-23.9 kg/m 2 ), and overweight/obesity (≥ 24 kg/m 2 ). The primary outcome was all-cause hospital mortality. RESULTS Among 2327 patients, 297 (12.8%) were underweight, 1013 (43.5%) normal weight, and 1017 (43.7%) overweight/obesity. The all-cause hospital mortality was 4.6% (106/2327). Mortality was lowest in the overweight/obesity group and highest in the underweight group (2.8%, vs 5.0%, vs 9.1%, P < 0.001). All-cause mortality of overweight/obesity patients was lower than normal-weight patients [odds ratio (OR) = 0.535, 95% confidence interval (CI) = 0.334-0.855, P = 0.009], while the all-cause mortality of underweight patients was higher than that of normal-weight patients (OR = 1.886, 95%CI: 1.161-3.066, P = 0.010). Multivariable analysis showed that abnormal neutrophil counts (OR = 2.38, 95%CI: 1.55-3.65, P < 0.001), abnormal albumin levels (OR = 0.20, 95%CI: 0.06-0.72, P = 0.014), high-risk Confusion-Urea-Respiration-Blood pressure-65 score (OR = 2.89, 95%CI: 1.48-5.64, P = 0.002), and intensive care unit admission (OR = 3.11, 95%CI: 1.77-5.49, P < 0.001) were independently associated with mortality. CONCLUSION All-cause mortality of normal-weight patients was higher than overweight/ obesity patients, lower than that of underweight patients. Neutrophil counts, albumin levels, Confusion-Urea-Respiration-Blood pressure-65 score, and intensive care unit admission were independently associated with mortality in patients with community-acquired pneumonia.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Influence of overweight and obesity on the mortality of hospitalized patients with community-acquired pneumonia

Wang¹,

Liu²,

Ma³

et al. 2022

WJCC

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“…Easier studies conducted in this feld focused on obese patients with ICD, and the results showed an "obesity paradox" [19,20]. In the study by Echoufo-Tcheugui et al found that compared to normal-weight individuals, ≥65 years old patients with CRT-D who were underweight (BMI: 25-29.9 kg/m 2 ) had greater risks of mortality and hospitalization, while those who were overweight (BMI ≥ 30 kg/m 2 ) or obese had a lower mortality risk [19].…”

Section: Discussionmentioning

confidence: 97%

[Retracted] Sex Differences in the Relationship between Abdominal Obesity and Cardiovascular Death in Elderly Patients with Permanent Pacemakers Implantation: A Retrospective Cohort Study

Xue

Zhao

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Objectives. This study aims to investigate the association between waist circumference (WC) and cardiovascular death in patients with permanent pacemakers (PPMs). Methods. This is a retrospective cohort study that enrolled patients who underwent PPM implantation in Fuwai Hospital from May 2010 to April 2014, according to the BIOTRONIK Home Monitoring database. The WC was treated as sex-specific quartiles, and patients were divided into three groups according to body mass index (BMI): normal (≤22.9 kg/m2), overweight (23–24.9 kg/m2), and obese (≥25 kg/m2). Cox proportional hazards models were used to calculate hazard ratios and 95% confidence intervals for cardiovascular death according to WC and BMI in patients. Results. 492 patients with PPMs implantation were analyzed (mean age: 71.9 ± 10.8 years; 55.1% men (n = 271)). Data showed that after a mean follow-up 67.2 ± 17.5 months, 24 (4.9%) patients had experienced cardiovascular death and 71 (14.4%) were cases of all-cause mortality. Men in the third quartile of WC had an HR of 10.67 (Model 4, 95% CI: 1.00–115.21, p trend = 0.04) for cardiovascular death. However, the association disappeared in female patients (Model 4, HR = 3.99, 95% CI: 0.37–42.87, p trend = 0.25). There was no association between BMI and cardiovascular death or all-cause mortality in both male and female patients. Conclusions. Abdominal obesity was associated with an increased risk of cardiovascular death in patients with PPMs, and this relationship was only in male patients.

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“…The effectiveness of secondary ICD prophylaxis has been confirmed by many studies and thus this prophylaxis is generally accepted [ 4 , 6 , 7 ]. On the other hand, the results of studies examining the effect of BMI are inconsistent [ 61 , 62 , 63 , 64 , 65 , 66 ]. Despite the well-known harmful effect on CV health, some studies showed a paradoxically favourable prognosis in overweight and obese cardiac patients.…”

Section: Discussionmentioning

confidence: 99%

Let It Beat: How Lifestyle and Psychosocial Factors Affect the Risk of Sudden Cardiac Death—A 10-Year Follow-Up Study

Obrova

Sovová

Ivanová

et al. 2022

IJERPH

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(1) Background: The aim of this study was to evaluate the lifestyle and occurrence of psychosocial factors in patients with a high risk of sudden cardiac death (SCD) and to explore their effect on the occurrence of the adequate therapy of an Implantable Cardioverter Defibrillator (ICD). (2) Methods: In this retro-prospective single-centre study, a group of patients aged 18–65 years old, who underwent the first ICD implantation for primary (PP) or secondary (SP) prevention between 2010–2014, was studied. The control group consisted of pair-matched (age ± 5 years, gender) respondents without a high risk of SCD. Information was obtained using a self-reported questionnaire and hospital electronic health records. The adequacy of ICD therapy was evaluated regularly until 31 January 2020. Multivariate logistic regression models were employed to assess the risk of SCD. (3) Results: A family history of SCD, coronary artery disease, diabetes mellitus and depression significantly aggravated the odds of being at a high risk of SCD. The occurrence of an appropriate ICD therapy was significantly associated with being in the SP group, BMI, education level and TV/PC screen time. (4) Conclusions: Lifestyle and psychosocial factors have been confirmed to affect the risk of SCD. Early identification and treatment of coronary artery disease and its risk factors remain the cornerstones of preventive effort. Further research is needed to evaluate the complex nature of psychosocial determinants of cardiac health.

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Overweight and obesity as protective factors against mortality in nonischemic cardiomyopathy patients with an implantable cardioverter defibrillator

Cited by 5 publications

References 29 publications

Influence of overweight and obesity on the mortality of hospitalized patients with community-acquired pneumonia

Influence of overweight and obesity on the mortality of hospitalized patients with community-acquired pneumonia

[Retracted] Sex Differences in the Relationship between Abdominal Obesity and Cardiovascular Death in Elderly Patients with Permanent Pacemakers Implantation: A Retrospective Cohort Study

Let It Beat: How Lifestyle and Psychosocial Factors Affect the Risk of Sudden Cardiac Death—A 10-Year Follow-Up Study

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