Overweight is gender-dependent in prenatal protein–calorie restricted adult rats acting on the blood pressure and the adverse cardiac remodeling

Almeida, Jorge Reis; Mandarim-de-Lacerda, Carlos Alberto

doi:10.1016/j.lfs.2004.12.043

Cited by 16 publications

(6 citation statements)

References 43 publications

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“…Literature concerning different aspects of sexual dimorphism in LP offspring support this notion (Almeida and Mandarim-de-Lacerda, 2005b;McMullen and Langley-Evans, 2005), mainly in moderate LP pregnancies like in this study (Woods et al, 2005).…”

Section: Discussionsupporting

confidence: 79%

Adult cardiorenal benefits from postnatal fish oil supplement in rat offspring of low-protein pregnancies

et al. 2006

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Section: Discussionsupporting

confidence: 79%

Adult cardiorenal benefits from postnatal fish oil supplement in rat offspring of low-protein pregnancies

et al. 2006

Self Cite

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“…Thus, these changes in cardiovascular parameters could be due to several factors including hyperleptinaemia, increased function of the adrenal medulla or raised levels of thyroid hormones. Although there has been no report of kidney dysfunction in this model, it is known that neonatal undernutrition is associated with glomerular dysfunction in adulthood (Langley‐Evans et al 1999; Almeida & Mandarim‐de‐Lacerda, 2005).…”

Section: Discussionmentioning

confidence: 83%

Neonatal hyperleptinaemia programmes adrenal medullary function in adult rats: effects on cardiovascular parameters

Trevenzoli

Valle

Machado

et al. 2007

The Journal of Physiology

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Epidemiological studies have shown a strong correlation between stressful events (nutritional, hormonal or environmental) in early life and development of adult diseases such as obesity, diabetes and cardiovascular failure. It is known that gestation and lactation are crucial periods for healthy growth in mammals and that the sympathoadrenal system is markedly influenced by environmental conditions during these periods. We previously demonstrated that neonatal hyperleptinaemia in rats programmes higher body weight, higher food intake and hypothalamic leptin resistance in adulthood. Using this model of programming, we investigated adrenal medullary function and effects on cardiovascular parameters in male rats in adulthood. Leptin treatment during the first 10 days of lactation (8µg 100 g −1 day −1 , S.C.) resulted in lower body weight (6.5%, P < 0.05), hyperleptinaemia (10-fold, P < 0.05) and higher catecholamine content in adrenal glands (18.5%, P < 0.05) on the last day of treatment. In adulthood (150 days), the rats presented higher body weight (5%, P < 0.05), adrenal catecholamine content (3-fold, P < 0.05), tyrosine hydroxylase expression (35%, P < 0.05) and basal and caffeine-stimulated catecholamine release (53% and 100%, respectively, P < 0.05). Systolic blood pressure and heart rate were also higher in adult rats (7% and 6%, respectively, P < 0.05). Our results show that hyperleptinaemia in early life increases adrenal medullary function in adulthood and that this may alter cardiovascular parameters. Thus, we suggest that imprinting factors which increase leptin and catecholamine levels during the neonatal period could be involved in development of adult chronic diseases.

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“…Several animal studies have implied that perturbations of the nutritional or metabolic environment can influence myocardial development and function in later life (Roigas et al 1996, Bae et al 2003, Davis et al 2003, Han et al 2004, Almeida & Mandarim-de-Lacerda 2005, Battista et al 2005, Cheema et al 2005, Catta-Preta et al 2006, Fernandez-Twinn et al 2006, Xu et al 2006, Elmes et al 2007, Chan et al 2009, Porrello et al 2009, Tappia et al 2009, Xue & Zhang 2009). Experimental placental mass reduction, foetal hypertension and cortisol exposure all affect proliferation and terminal maturation of the neonatal cardiac myocytes (Giraud et al 2006.…”

Section: Developmental Programming Of Cardiac Functionmentioning

confidence: 99%

Maternal obesity and the developmental programming of hypertension: a role for leptin

2014

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Mother-child cohort studies have established that both pre-pregnancy body mass index (BMI) and gestational weight gain are independently associated with cardio-metabolic risk factors in young adult offspring, including systolic and diastolic blood pressure. Animal models in sheep and non-human primates provide further evidence for the influence of maternal obesity on offspring cardiovascular function, whilst recent studies in rodents suggest that perinatal exposure to the metabolic milieu of maternal obesity may permanently change the central regulatory pathways involved in blood pressure regulation. Leptin plays an important role in the central control of appetite, is also involved in activation of efferent sympathetic pathways to both thermogenic and non-thermogenic tissues, such as the kidney, and is therefore implicated in obesity-related hypertension. Leptin is also thought to have a neurotrophic role in the development of the hypothalamus, and altered neonatal leptin profiles secondary to maternal obesity are associated with permanently altered hypothalamic structure and function. In rodent studies, maternal obesity confers persistent sympathoexcitatory hyper-responsiveness and hypertension acquired in the early stages of development. Experimental neonatal hyperleptinaemia in naive rat pups provides further evidence of heightened sympathetic tone and proof of principle that hyperleptinaemia during a critical window of hypothalamic development may directly lead to adulthood hypertension. Insight from these animal models raises the possibility that early-life exposure to leptin in humans may lead to early onset essential hypertension. Ongoing mother-child cohort and intervention studies in obese pregnant women provide a unique opportunity to address associations between maternal obesity and offspring cardiovascular function. The goal of the review is to highlight the potential importance of leptin in the developmental programming of hypertension in obese pregnancy.

show abstract

Overweight is gender-dependent in prenatal protein–calorie restricted adult rats acting on the blood pressure and the adverse cardiac remodeling

Cited by 16 publications

References 43 publications

Adult cardiorenal benefits from postnatal fish oil supplement in rat offspring of low-protein pregnancies

Adult cardiorenal benefits from postnatal fish oil supplement in rat offspring of low-protein pregnancies

Neonatal hyperleptinaemia programmes adrenal medullary function in adult rats: effects on cardiovascular parameters

Maternal obesity and the developmental programming of hypertension: a role for leptin

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