Ovine Chlamydial Abortion: Characterization of the Inflammatory Immune Response in Placental Tissues

Buxton, D.; Anderson, I.E.; Longbottom, David; Livingstone, Morag; Wattegedera, Sean; Entrican, Gary

doi:10.1053/jcpa.2002.0573

Cited by 79 publications

(72 citation statements)

References 22 publications

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“…When both inflammation and focal leukoencephalomalacia are seen together, diagnosis is reasonably certain, but less commonly it could also be seen in chlamydialabortion [3] or tick-borne fever [4].…”

Section: Discussionmentioning

confidence: 99%

Pathological description and immunohistochemical demonstration of ovine abortion associated with Toxoplasma gondii in Iran

Rassouli¹,

Razmi²,

Movassaghi³

et al. 2013

Korean Journal of Veterinary Research

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:The obligatory intracellular protozoan parasite Toxoplasma gondii is a major world wide cause of infectious ovine abortion. In some different diagnostic techniques that are being used to detect this pathogen in ovine fetuses, immunohistochemistry (IHC) is a very sensitive and expensive one. Histopathology is not truly a specific and sensitive test for Toxoplasma infection but it can be helpful to choose some suspected tissues for IHC. In this study 9.5% of 200 samples (aborted ovine fetuses internal organs such as brain, liver, heart, lung, kidney, spleen) (4.6~14.4% with 95% CI) were positive in IHC with a very good logical agreement among different diagnostic techniques (κ = 0.73, 0.8) and with no significant difference among different fetal age groups (p > 0.05).

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Section: Discussionmentioning

confidence: 99%

Pathological description and immunohistochemical demonstration of ovine abortion associated with Toxoplasma gondii in Iran

Rassouli¹,

Razmi²,

Movassaghi³

et al. 2013

Korean Journal of Veterinary Research

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“…This was achieved by conducting a retrospective analysis of serum samples derived from a pregnant-ewe challenge experiment to characterize the inflammatory immune response to C. abortus infection in the placenta (8). The potential of each antigen for use as a diagnostic reagent for detecting EAE is discussed.…”

mentioning

confidence: 99%

Antibody Responses to Recombinant Protein Fragments of the Major Outer Membrane Protein and Polymorphic Outer Membrane Protein POMP90 inChlamydophila abortus-Infected Pregnant Sheep

Livingstone

Entrican

Wattegedera

et al. 2005

Clin Vaccine Immunol

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Chlamydophila abortus is one of the major causes of infectious abortion in pregnant sheep (enzootic abortion of ewes or EAE) worldwide. Organisms shed in infected placentas and uterine discharges at lambing time are the main sources of environmental contamination, responsible for transmission to susceptible animals and possible human contacts. In the present study, a recently developed test, based on a recombinant fragment of the polymorphic outer membrane protein POMP90 (rOMP90-4 indirect enzyme-linked immunosorbent assay [iELISA]) and one based on the variable segment 2 (VS2) region of the major outer membrane protein (MOMP) (MOMP VS2 iELISA) were compared using sera from C. abortus-infected ewes at different stages throughout pregnancy. The rOMP90 iELISA detected antibody much earlier in pregnancy than the MOMP iELISA, which, like the complement fixation test, detected antibody only at the time of abortion or lambing. No anti-MOMP antibody response could be detected in three of seven experimentally infected ewes. Furthermore, the rOMP90 iELISA detected antibody in an animal that seroconverted during the course of the study, which the MOMP iELISA failed to detect. Overall, the results show that the rOMP90-4 iELISA is considerably more sensitive than the MOMP VS2 iELISA for identifying animals infected with C. abortus. Earlier detection of infection will allow appropriate control measures to be taken to reduce environmental contamination, thus limiting the spread of infection, financial losses, and the possible risks of zoonotic transmission to humans.

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“…Other factors may play an important role in activating the abortion process. Inflammatory cytokines, such as IFN-␥, produced in response to infection at the ma-ternal-fetal interface have been postulated to abrogate normal placentation and predispose the mother and fetus to adverse reproductive outcomes, including miscarriage and fetal growth restriction (7,20). The role of IFN-␥ in abortion in mice infected with C. abortus AB7 has been demonstrated in a knockout mouse model, since IFN-␥ knockout mice aborted earlier than the wild-type mice in spite of a lower level of placental infection (I. Benchaîeb, personal communication).…”

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confidence: 99%

Abortive Potency ofChlamydophila abortusin Pregnant Mice Is Not Directly Correlated with Placental and Fetal Colonization Levels

2003

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Abortion, placental and fetal colonization, and levels of gamma interferon were analyzed for four Chlamydophila abortus strains presenting antigenic variations in a mouse model. Expression of virulence of these strains varied and indicated that abortion was not directly related to the number of bacteria in the placenta, and thus, other factors may have an important role in activating the abortion process.

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Ovine Chlamydial Abortion: Characterization of the Inflammatory Immune Response in Placental Tissues

Cited by 79 publications

References 22 publications

Pathological description and immunohistochemical demonstration of ovine abortion associated with Toxoplasma gondii in Iran

Pathological description and immunohistochemical demonstration of ovine abortion associated with Toxoplasma gondii in Iran

Antibody Responses to Recombinant Protein Fragments of the Major Outer Membrane Protein and Polymorphic Outer Membrane Protein POMP90 inChlamydophila abortus-Infected Pregnant Sheep

Abortive Potency ofChlamydophila abortusin Pregnant Mice Is Not Directly Correlated with Placental and Fetal Colonization Levels

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