Ovine forestomach matrix biomaterial is a broad spectrum inhibitor of matrix metalloproteinases and neutrophil elastase

Negron, Leonardo; Lun, S.; May, Barnaby C. H.

doi:10.1111/j.1742-481x.2012.01106.x

Cited by 38 publications

(55 citation statements)

References 37 publications

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“…2 In this same comparative study, the soluble components of the CECM biomaterial inhibited all MMPs tested, including collagen, stromelysins, and gelatinases. Similar inhibitory potency between ORC/C and CECM extracts were determined only for the gelatinases, MMP-2 and MMP-9.…”

Section: Ovine-based Collagen Matrix Dressingmentioning

confidence: 82%

“…Collagen dressings have been shown to reduce MMP levels, acting as a sacrificial substrate for excessive proteases in chronic wounds. [1][2][3] New ovine-based collagen extracellular matrix (CECM) dressings (EndoformÔ dermal template; Hollister Wound Care, Libertyville, IL) exhibit broad-spectrum MMP inhibition and can serve as a provisional matrix to affect cellular signaling and differentiation that may enhance wound healing.…”

Section: Scope and Significancementioning

confidence: 99%

“…5 Soluble components of the CECM biomaterial inhibited all MMPs tested, including collagen, stromelysins, and gelatinases. 2 …”

Section: Scope and Significancementioning

confidence: 99%

“…Ovine-based CECM dressings are prepared from propria submucosa of ovine forestomach tissue using processes to delaminate and decellularize the tissue. 2,22 Dressings are processed using a proprietary method that retains the complex collagen architecture of native tissue ECM.…”

Section: Ovine-based Collagen Matrix Dressingmentioning

confidence: 99%

“…3,17,18 Collagen has been shown to reduce MMP levels, acting as a sacrificial substrate for excessive proteases in a chronic wound. 1,2,19 As such, collagen can reduce the excessive protease activity in a wound to a level that may allow healing to proceed.…”

mentioning

confidence: 99%

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Ovine-Based Collagen Matrix Dressing: Next-Generation Collagen Dressing for Wound Care

Bohn¹,

Liden²,

Schultz

et al. 2016

Advances in Wound Care

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Significance: Broad-spectrum metalloproteinase (MMP) reduction along with inherent aspects of an extracellular matrix (ECM) dressing can bring about improved wound healing outcomes and shorter treatment duration. Initial reports of clinical effectiveness of a new ovine-based collagen extracellular matrix (CECM) dressing demonstrate benefits in chronic wound healing. Recent Advances: CECM dressings are processed differently than oxidized regenerated cellulose/collagen dressings. CECM dressings consist primarily of collagens I and III arranged as native fibers that retain the three-dimensional architecture present in tissue ECM. As such, ovine-based ECM dressings represent a new generation of collagen dressings capable of impacting a broad spectrum of MMP excess known to be present in chronic wounds. Critical Issues: While MMPs are essential in normal healing, elevated presence of MMPs has been linked to wound failure. Collagen has been shown to reduce levels of MMPs, acting as a sacrificial substrate for excessive proteases in a chronic wound. Preserving collagen dressings in a more native state enhances bioactivity in terms of the ability to affect the chronic wound environment. Clinical observation and assessment may not be sufficient to identify a wound with elevated protease activity that can break down ECM, affect wound fibroblasts, and impair growth factor response. Future Directions: Collagen dressings that target broad-spectrum excessive MMP levels and can be applied early in the course of care may positively impact healing rates in difficult wounds. Next-generation collagen dressings offer broader MMP reduction capacity while providing a provisional dermal matrix or ECM. SCOPE AND SIGNIFICANCESelecting treatment based on a scientific understanding of the pathological condition of a chronic wound is important in addressing cost and patient needs. Harmful effects of excessive metalloproteinase (MMP) activity in chronic wound healing should be a consideration of wound care decision making. Collagen dressings have been shown to reduce MMP levels, acting as a sacrificial substrate for excessive proteases in chronic wounds. 1-3New ovine-based collagen extracellular matrix (CECM) dressings (EndoformÔ dermal template; Hollister Wound Care, Libertyville, IL) exhibit broad-spectrum MMP inhibition and can serve as a provisional matrix to affect cellular signaling and differentiation that may enhance wound healing. 2 TRANSLATIONAL RELEVANCEDegradation of collagen is important for the physiological remodeling of connective tissues during wound healing. Extracellular degradation of collagen fibers is mediated by MMPs and is a multistep process. A collagen dressing with a preserved structural component can serve as a provisional ECM dermal template and influence cellular interaction necessary to encourage keratinocyte migration. 4 CECM dressings have been shown to retain the complex collagen architecture of native tissue ECM as well as the ECM-associated secondary molecules, including laminin, fibronectin, and glycosam...

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Section: Ovine-based Collagen Matrix Dressingmentioning

confidence: 82%

Section: Scope and Significancementioning

confidence: 99%

“…5 Soluble components of the CECM biomaterial inhibited all MMPs tested, including collagen, stromelysins, and gelatinases. 2 …”

Section: Scope and Significancementioning

confidence: 99%

Section: Ovine-based Collagen Matrix Dressingmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Ovine-Based Collagen Matrix Dressing: Next-Generation Collagen Dressing for Wound Care

Bohn¹,

Liden²,

Schultz

et al. 2016

Advances in Wound Care

View full text Add to dashboard Cite

show abstract

Updates on Recent Clinical Assessment of Commercial Chronic Wound Care Products

Sharma

Zhao

2023

Adv Healthcare Materials

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Impaired wound healing after trauma, disorders, and surgeries impact millions of people globally every year. Dysregulation in orchestrated healing mechanisms and underlying medical complications make chronic wound management extremely challenging. Besides standard‐of‐care treatments including broad spectrum antibiotics and wound‐debridement, novel adjuvant therapies are clinically tested and commercialized. These include topical agents, skin substitutes, growth factor delivery, and stem cell therapies. With a goal to overcome factors playing pivotal role in delayed wound healing, researchers are exploring novel approaches to elicit desirable healing outcomes in chronic wounds. Although recent innovations in wound care products, therapies, and devices are extensively reviewed in past, a comprehensive review summarizing their clinical outcomes is surprisingly lacking. Herein, this work reviews the commercially available wound care products and their performance in clinical trials to provide a statistically comprehensive understanding of their safety and efficacy. The performance and suitability of various commercial wound care platforms, including xenogeneic and allogenic products, wound care devices, and novel biomaterials, are discussed for chronic wounds. The current clinical evaluation will provide a comprehensive understanding of the benefits and drawbacks of the most‐recent approaches and will enable researchers and healthcare providers to develop next‐generation technologies for chronic wound management.

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Approaches to Control and Monitor Protease Levels in Chronic Wounds

Kolahreez,

Ghasemi‐Mobarakeh,

Liebner

et al. 2024

Advanced Therapeutics

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Some wounds do not follow the typical healing trajectory and show very little, if any, progress. They dreadfully threaten the patients' quality of life and may even lead to limb amputation and death. Several interrelated systemic and local factors may cause a delay in wound healing. The microenvironment of these wounds could be different from wounds that heal spontaneously or with standard treatment. As discussed in the present work, proteases’ levels or activity could be elevated in some cases of chronic ulcers; infection could aggravate the situation. A detailed overview of the proteases’ effect on wound healing is presented in this paper. Assuming untimely or irregularly excessive proteolytic activity plays a pathological role, some researchers targeted attenuation of protease level as a strategy to promote healing. This could be done via different approaches, including physical removal, inhibiting their activity, and controlling their expression directly through gene silencing or indirectly, for instance, by resolving infection. Apart from targeting protease modulation as a therapeutic strategy, many studies have examined the protease state to gain insights into the underlying mechanisms by which a remedy, dressing, or specific therapy has affected the healing process. This article aims to provide an overview of the studies in these two categories. Of course, various proteases are involved in the healing process, but in each study, usually, only one or some of them were investigated; matrix metalloproteinase‐2 (MMP‐2), MMP‐9, and human neutrophil elastase (HNE) are among them. Furthermore, in some cases, cumulative proteolytic activity has been evaluated in terms of gelatinolytic, collagenolytic, or caseinolytic activity, which is also absolutely beneficial. Some research groups have considered the potential of proteases as a diagnostic or prognostic biomarker and have tried to develop some sensors or indicators; this topic has also been covered in the present work.This article is protected by copyright. All rights reserved

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Ovine forestomach matrix biomaterial is a broad spectrum inhibitor of matrix metalloproteinases and neutrophil elastase

Cited by 38 publications

References 37 publications

Ovine-Based Collagen Matrix Dressing: Next-Generation Collagen Dressing for Wound Care

Ovine-Based Collagen Matrix Dressing: Next-Generation Collagen Dressing for Wound Care

Updates on Recent Clinical Assessment of Commercial Chronic Wound Care Products

Approaches to Control and Monitor Protease Levels in Chronic Wounds

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