Ovulation: New Dimensions and New Regulators of the Inflammatory-Like Response

Richards, JoAnne S.; Russell, Darryl L.; Ochsner, Scott A.; Espey, Lawrence L.

doi:10.1146/annurev.physiol.64.081501.131029

Cited by 389 publications

(268 citation statements)

References 153 publications

Supporting

Mentioning

258

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, fertilization rate and clinical pregnancy rate were found to be dependent on the optimum timing of oocyte retrieval after HCG injection. As LH surge triggers acute inflammation and ROS production in the ovary [47], it is reasonable to expect that higher levels of LH lead to higher ROS production in MNIVF. The exposure of only one follicle to excessive inflammation and thus higher ROS levels could have detrimental effects on oocyte quality and success rates of MNIVF.…”

Section: Discussionmentioning

confidence: 99%

Differences in cumulus cells gene expression between modified natural and stimulated in vitro fertilization cycles

Papler

Bokal

Tacer

et al. 2013

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose The aim of our study was to determine whether there are any differences in the cumulus cell gene expression profile of mature oocytes derived from modified natural IVF and controlled ovarian hyperstimulation cycles and if these changes could help us understand why modified natural IVF has lower success rates. Methods Cumulus cells surrounding mature oocytes that developed to morulae or blastocysts on day 5 after oocyte retrieval were submitted to microarray analysis. The obtained data were then validated using quantitative real-time PCR. Results There were 66 differentially expressed genes between cumulus cells of modified natural IVF and controlled ovarian hyperstimulation cycles. Gene ontology analysis revealed the oxidation-reduction process, glutathione metabolic process, xenobiotic metabolic process and gene expression were significantly enriched biological processes in MNIVF cycles.Among differentially expressed genes we observed a large group of small nucleolar RNA's whose role in folliculogenesis has not yet been established. Conclusion The increased expression of genes involved in the oxidation-reduction process probably points to hypoxic conditions in modified natural IVF cycles. This finding opens up new perspectives for the establishment of the potential role that oxidation-reduction processes have in determining success rates of modified natural IVF.

show abstract

Section: Discussionmentioning

confidence: 99%

Differences in cumulus cells gene expression between modified natural and stimulated in vitro fertilization cycles

Papler

Bokal

Tacer

et al. 2013

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…In the mammalian ovary, COX-2 is localized to the granulosa cells and induced by LH at the time of the preovulatory gonadotropin surge [43]. In the hen ovary, COX-2 is also expressed in the granulosa cells, as shown in Fig.…”

Section: Localization and Quantification Of Cox-1 And Cox-2 In The Hementioning

confidence: 92%

Cyclooxygenases expression and distribution in the normal ovary and their role in ovarian cancer in the domestic hen (Gallus domesticus)

Hales

Zhuge

Lagman

et al. 2008

Endocr

View full text Add to dashboard Cite

Cyclooxygenase (COX) (PTGS) is the rate-limiting enzyme in the biosynthesis of prostaglandins. Two COX isoforms have been identified, COX-1 and COX-2, which show distinct cell-specific expression and regulation. Ovarian cancer is the most lethal gynecological malignancy and the © Humana Press Inc. 2008 Correspondence to: Dale Buchanan Hales, dbhale@uic.edu. HHS Public Access Author ManuscriptAuthor Manuscript Author ManuscriptAuthor Manuscript disease is poorly understood due to the lack of suitable animal models. The laying hen spontaneously develops epithelial ovarian cancer with few or no symptoms until the cancer has progresses to a late stage, similar to the human disease. The purpose of this study was to examine the relative expression and distribution of COX-1 and COX-2 in the ovaries of normal hens and in hens with ovarian cancer. The results demonstrate that COX-1 was localized to the granulosa cell layer and cortical interstitium, ovarian surface epithelium (OSE) and postovulatory follicle (POF) of the normal ovary. In ovarian cancer, COX-1 mRNA was significantly increased and COX-1 protein was broadly distributed throughout the tumor stroma. COX-2 protein was localized to the granulosa cell layer in the follicle and the ovarian stroma. COX-2 mRNA expression did not change as a function of age or in ovarian cancer. There was significantly higher expression of COX-1 mRNA in the first POF (POF-1) compared to POF-2 and POF-3. COX-2 mRNA expression was not significantly different among POFs. There was no difference in COX-1 or COX-2 mRNA in the OSE isolated from individual follicles in the follicular hierarchy. The results confirm previous findings of the high expression of COX-1 in ovarian tumors further supporting the laying hen as a model for ovarian cancer, and demonstrate for the first time the high expression of COX-1 in POF-1 which is the source of prostaglandins needed for oviposition.

show abstract

“…The COCs are exposed to widely varying circumstances after ovulation. Ovulation and follicular rupture are characterized by inflammation-like processes, such as matrix metalloproteinase expression and cytokine production (28). Gene expression of interleukin-1␤ (IL-1␤; Il1b) in the ovary has been shown to increase after ovulation (29).…”

Section: Integrin-dependent Hyaluronidase Resistance Causes Fertilizamentioning

confidence: 99%

Timely interaction between prostaglandin and chemokine signaling is a prerequisite for successful fertilization

Tamba¹,

Yodoi²,

Segi-Nishida

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Timely interaction between the egg and sperm is required for successful fertilization; however, little is known about the signaling therein. Prostaglandin (PG) E receptor EP2-deficient (Ptger2 ؊/؊ ) female mice exhibit a severe fertilization defect. We investigated the molecular events leading to this failure. We found increased gene expression for chemokines, such as Ccl2, Ccl7, and Ccl9, in Ptger2 ؊/؊ cumulus cells (the somatic cells surrounding the egg) compared with wild-type cells. Furthermore, under physiological conditions, cumulus-derived chemokine signaling was found to have a dual action; CCL7 facilitates sperm migration to the cumulus-egg complex and integrin-mediated cumulus extracellular matrix (ECM) assembly to protect eggs. However, in the absence of PGE 2-EP2 signaling, chronic CCL7 signaling results in excessive integrin engagement to the ECM, making the cumulus ECM resistant to sperm hyaluronidase, thereby preventing sperm penetration. Our findings indicate that PGE 2-EP2 signaling negatively regulates the autocrine action of chemokines and prevents excessive cumulus ECM assembly. This interaction between PG and chemokine signaling is required for successful fertilization.O vulation and fertilization are key processes in mammalian female reproduction, which are strictly regulated by pituitary gonadotropins, follicle-stimulating hormone, and luteinizing hormone. These hormones induce various preovulatory processes, including follicular development, oocyte maturation, and cumulus expansion, and trigger ovulation (1). Ovulated eggs move to the oviduct; subsequently the timely interaction between an egg and sperm leads to successful fertilization (2). Whereas various molecules are known to regulate preovulatory processes locally in the follicle under the control of gonadotropin (3), little is known about the regulation of postovulatory processes, including fertilization in the oviduct, which gonadotropin does not control.One potential candidate for the local mediators regulating fertilization within the oviduct is chemokines. Chemokines constitute a family of structurally related, inducible peptides involved in various immune responses and inflammation, acting as chemoattractants and activators of specific types of leukocytes (4). Approximately 40 chemokines, grouped into distinct families and secreted by various cells, are currently known (5). It was recently reported that in humans, CCL5 (also called RANTES) is present in the follicular fluid and stimulates the in vitro migration of sperm, which express CCR1, a receptor for CCL5 (6). Based on these findings, it has been proposed that chemokines may participate in sperm guidance within the genital tract (7). The physiological significance of such chemokine signaling within the oviduct remains elusive, however.The cumulus oophorus is composed of a group of closely associated granulosa cells that surround the oocyte in the antral follicle and are collectively called cumulus cells (8). In response to a surge in luteinizing hormone, the cumulus cells ...

show abstract

Ovulation: New Dimensions and New Regulators of the Inflammatory-Like Response

Cited by 389 publications

References 153 publications

Differences in cumulus cells gene expression between modified natural and stimulated in vitro fertilization cycles

Differences in cumulus cells gene expression between modified natural and stimulated in vitro fertilization cycles

Cyclooxygenases expression and distribution in the normal ovary and their role in ovarian cancer in the domestic hen (Gallus domesticus)

Timely interaction between prostaglandin and chemokine signaling is a prerequisite for successful fertilization

Contact Info

Product

Resources

About