Oxazepines and Thiazepines. Part 44. Reductive Formation of 1,5‐Benzothiazepines.

Abstract

Oxazepines and Thiazepines. Part 44. Reductive Formation of 1,5-Benzothiazepines. -Reaction of substrates (I) with excess 2-aminothiophenol results in an unprecedented formation of 1,5-benzothiazepines having an exocyclic double bond. -(LEVAI*, A.; TOTH, G.; GONDOS, T.; JEKO, J.; BRAHMBHATT, D. I.; Heterocycles 68 (2006) 7, 1319-1324; Dep. Org. Chem., Lajos Kossuth Univ., H-4010 Debrecen, Hung.; Eng.) -Mais 47-188

Chalcone derived benzoheterodiazepines for medicinal applications: A Two‐pot and one‐pot synthetic approach

“…Benzoheterodiazepine derivatives are designed from different reactants such as cinnamoylacetonitrile [64], hydrazone [65], flavone [66], chalcone [67], α-haloketones [68,69], ethyl acetoacetate [70], cinnamoyl cyanide [71], propargylic alcohols [72], or ketones [73][74][75]. The condensation of diamines (i.e., o-phenylenediamine, o-aminothiophenol, o-aminophenol) and chalcones [76,77] is common under different modes of reactions (i.e., stirring [78], grindstone [79], reflux [80,81], MW [82,83], and ultrasonic irradiations [84,85]) in the presence of catalysts (i.e., piperidine [86,87], NaOH [88,89], NaOAc [90], acetic acid [91,92], trifluoroacetic acid [93], InCl 3 [94], alumina [82], volcanic ash [95], Ti(OiPr) 4 [77], MgO-ZrO 2 [96], SmI 2 [78], SiO 2 [97], Al 2 O 3 [80], TiCl 4 /Sm [98], Bi(NO 3 ) 3 -Al 2 O 3 [99], La Y zeolite [100], HClO 4 -SiO 2 [101], Fe 3 O 4 [102], B(HSO 4 ) 3 …”