Oxidant and antioxidant levels in children with acute otitis media and tonsillitis: A comparative study

Efficacy of vitamin A in experimentally induced acute otitis media

“…Several studies reported increased antioxidant enzyme activity during infections. Nevertheless in a recent report, antioxidant enzyme activities were determined with a diminished level in patient group with AOM compared with normal population [16]. In current study, blood SOD and GSH-Px activities were significantly increased in the group receiving both antibiotic and vitamin A compared to the group receiving only antibiotic.…”

“…Our hypothesis depends on the fact that vitamin A is essential for immunity and maintenance for respiratory epithelium. In a recent report by Cemek et al [16], nonenzymatic antioxidants levels such as vitamin A, vitamin C and vitamin E were determined lower in children with AOM compared with healthy control subjects. Unal et al [17] have studied the therapeutic role of vitamin A in acute sinusitis based on histopathologic examinations.…”

Free Radicals and Oxidative Stress: Basic Concepts and Misconceptions

“…A sudden acceleration in the production of free radicals (i.e., ischemia reperfusion) or a chronic defi ciency in the antioxidant defense system may alter this balance, which leads to free-radical-induced damage to biomolecules, and may be further involved in the pathogenesis of various disorders and diseases (Valko et al 2007 ). Levels of beta-carotene, retinol, vitamin E, and vitamin C, for example, were observed to be signifi cantly decreased in children with acute otitis media and tonsillitis (Cemek et al 2005 ). Manjunath et al reported that serum MDA levels were signifi cantly elevated and that ferric reducing antioxidant power was dramatically decreased in patients with laryngeal and hypopharyngeal cancer (Manjunath et al 2010 ).…”

“…Current understanding of the involvement of free radicals in pathology suggests that antioxidant therapy through attenuating free radicals may be important to optimize treatment (Ding et al 2013 ;Tian et al 2013 ;Someya et al 2010 ;Cemek et al 2005 ). Most studies using animal models indicate the benefi ts of antioxidants in the prevention of acute oxidative conditions and diseases.…”

Are Vitamins and Trace Elements Important in Children with Chronic and Recurrent Tonsillitis

“…7 Vitamin A ve E nonenzimatik antioksidan defans sistemlerindendir. 8 Düşük antioksidan seviyelerinin kronik enfeksiyonların hem sebebi hem de sonucu olabileceği bildirilmiştir. 9 Kronik ve rekürren tonsilllit çocukluk çağında en sık görülen enfeksiyon hastalıklarından biridir.…”