Oxidant/antioxidant status in blood of patients with malignant breast tumour and benign breast disease

Abstract

The aim of this study was to investigate the alterations in lipid peroxidation and antioxidant enzyme defences in the blood of patients with malignant breast tumour and benign breast disease. Forty patients with malignant breast tumour, 20 patients with benign breast disease and also 20 healthy control subjects were recruited for the study. Malondialdehyde levels in plasma and erythrocytes, and the activities of erythrocyte CuZn-superoxide dismutase, catalase, glutathione peroxidase and glucose-6-phosphate dehydrogenase were measured. Malondialdehyde levels were higher in patients with both benign breast disease and malignant breast tumour compared with control subjects. The activities of all antioxidant enzymes were higher in patients with malignant breast tumour, while only glutathione peroxidase and CuZn-superoxide dismutase activities were higher in patients with benign breast disease. Except for glucose-6-phosphate dehydrogenase, the antioxidant enzymes studied correlated positively with the malondialdehyde levels in patients with malignant breast tumour. On the other hand, only glucose-6-phosphate dehydrogenase activity was increased by the level of malignancy. The activity increases in erythrocyte antioxidant enzymes may be a compensatory upregulation in response to increased oxidative stress especially in patients with malignant breast tumour.

Plasma and Dietary Carotenoids Are Associated with Reduced Oxidative Stress in Women Previously Treated for Breast Cancer

“…Further, the study populations were markedly different from those in the present study in that a significant percentage of subjects were male, many were smokers, and in the Moller study the mean study subject was >3 decades younger than our participants. The levels of oxidative stress in our study group were not as high as has been suggested for breast cancer patients in other studies (40)(41)(42)(43) and may be related to both the fact that our subjects were recruited, on average, just over two years after breast cancer diagnosis and are considered to be consuming relatively healthy diets since the time of breast cancer diagnosis (37). In fact, the plasma carotenoid concentrations observed in the present study sample are generally higher than those observed in the general population, as reflected in National Health and Nutrition Examination Survey III (44).…”

Blood volatile compounds as biomarkers for colorectal cancer

“…The available evidence indicates that in cases of various types of cancers, there are high levels of antioxidant enzyme activity and deficiencies in antioxidant vitamins. [30][31][32][33][34] The results of the current study revealed that CRC-specific VOCs in blood included the following compounds: phenyl methylcarbamate, ethylhexanol, 6-t-butyl-2,2,9,9-tetramethyl-3,5-decadien-7-yne, and 1,1,4,4-tetramethyl-2,5-dimethylenecyclohexane. The methylated alkanes, such as 1,1,4,4-tetramethyl-2, 5-dimethylene-cyclohexane, that were identified as CRC-specific VOCs in our results were similar to the metabolic biomarkers of melanoma that were identified by Abaffy et al, which include 4-methyl decane, dodecane, and undecane.…”

Lipid peroxidation the levels of antioxidant enzymes in hypertension

“…Oxidized glutathione (GSSG) is reduced back to GSH by glutathione reductase. [30][31][32][33] Reduced glutathione (GSH) and its redox enzymes are the most important cellular antioxidants and play a major role in protecting cells against oxidative stress caused by ROS. [34] Superoxide dismutases (SOD) are a class of enzymes that catalyze the dismutation of superoxide into oxygen and hydrogen peroxide.…”