Oxidant-antioxidant status in colorectal cancer patients—Before and after treatment

Abstract

Erythrocyte antioxidant glutathione and malondialdehyde levels in erythrocytes and plasma glutathione S-transferase levels were estimated in patients with colorectal cancer and compared to controls. Further, the patients underwent four weeks of radiotherapy with adjuvant chemotherapy. The same parameters were estimated after four weeks of radiotherapy and compared.with pretreatment levels. It was observed that there was a decrease in erythrocyte glutathione and malondialdehyde levels in patients with colorectal cancer compared to controls, but not in case of GST. However, after chemoradiotherapy, there were no statistically significant differences in all the parameters studied.

Saffron Reduction of 7,12-Dimethylbenz[a]anthracene-induced Hamster Buccal Pouch Carcinogenesis

“…Increase in GPx activity and GSH content in the buccal mucosa of hamsters treated with DMBA alone support the above findings (Manikandan et al, 2008). Lowered activities of SOD and CAT were reported in the tumor tissues of several cancerous conditions (Upadhya et al, 2004). Our results are in line with these findings.…”

Evaluation of glutathione in oral squamous cell carcinoma

“…Lower levels of GSH causes overproduction of free radicals and lipid peroxides which in turn may induce damage to the cell membrane and cellular molecules (DNA, RNA) leading to neoplasia. Similarly lower erythrocyte GSH levels in cervical cancer patients were reported by [7]. In contrast to decreased lipid peroxidation in tumor tissues, enhanced lipid peroxidation was associated with antioxidant depletion in the venous blood of OSCC patients [8,10,12].…”

Resonance elastic light scattering (RELS) spectroscopy of fast non-Langmuirian ligand-exchange in glutathione-induced gold nanoparticle assembly

“…It protects cells against organic peroxides and damaging radicals, and is involved in signaling processes associated with cell apoptosis. The diminished active GSH levels in cells and body fluids lead to the reduced antioxidation capacity [47] to protecting against radicals and have been found to increase susceptibility to autism [48,49], diabetes [50], and other diseases [47,[49][50][51][52][53][54][55]. The low GSH levels have been found to be caused by oxidative stress and exposure to toxic heavy metals (Hg, Cd, Pb).…”