Oxidative Addition of Cl<sub>2</sub>, HClO to Square‐Planar Pt<sup>II</sup> Complexes: Synthesis and Structural Characterization of Platinum(<scp>II</scp>) and Platinum(<scp>IV</scp>) Bis(amidate) Complexes

Liu, Fenghui; Chen, Wanzhi

doi:10.1002/ejic.200500878

Cited by 8 publications

(4 citation statements)

References 44 publications

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“…Compounds in which two new ligands are added as the result of oxidation (with hydrogen peroxide or chlorine) of Pt(II) to Pt(IV) complexes have also been reported for example by Dunham et al (1993), Pe´rez et al (2003) and Liu and Chen (2006).…”

Section: Analysis By Esi-ms Of Cisplatin Ozonation Products At Non-bumentioning

confidence: 87%

Ozonation of Cisplatin in Aqueous Solution at pH 9

Hernandez

Ramos

Fernández

et al. 2008

Ozone: Science & Engineering

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Ozonation of cisplatin [cis-diamminedichloroplatinum (II)] in non-buffered and buffered aqueous solutions at pH 9 was carried out at 303 K in a semi batch system at laboratory scale. The degradation of cisplatin and the formation of reaction products were analyzed by reverse phase high performance liquid chromatography. In the first two minutes of reaction practically all the initial cisplatin was depleted and only one major peak was observed in chromatograms under both experimental conditions. The structure of this main product was proposed after analysis by electrospray ionization tandem mass spectrometry (ESI-MS/MS). The mutagenicity of reaction mixture at non-buffered pH 9 was evaluated by performing Ames test. Non-mutagenic effect was observed. The second-order reaction rate constant of cisplatin with hydroxyl radical at pH 9 and 303 K was determined.

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Section: Analysis By Esi-ms Of Cisplatin Ozonation Products At Non-bumentioning

confidence: 87%

Ozonation of Cisplatin in Aqueous Solution at pH 9

Hernandez

Ramos

Fernández

et al. 2008

Ozone: Science & Engineering

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“…296,298 The reaction of diamine diamidate complexes of platinum(II) with NaOCl yields the corresponding trans hydroxo-chlorido platinum(IV) complexes (Scheme 21). 299 The tetrachloroaurate ion, [AuCl 4 ] − , can also oxidize platinum(II). The complex cis -[Pt(NH 3 ) 2 (1-methylthymine) 2 ] was oxidized by NaAuCl 4 to afford cis , cis , trans -[Pt(NH 3 ) 2 (1-methylthymine) 2 (OH)(OH 2 )].…”

Section: Synthesis Of Platinum(iv) Anticancer Complexesmentioning

confidence: 99%

Synthetic Methods for the Preparation of Platinum Anticancer Complexes

2013

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“…The first step in the design of Pt(IV) complexes is usually the oxidation of the desired Pt(II) precursor: most employed oxidants (e.g., hydrogen peroxide, tert-butyl hydrogen peroxide, N-halosuccinimide, halides) 12,[89][90][91][92][93][94][95][96][97] add two axial ligands to the parent square planar complex without any scrambling of the ligands (Fig. 5).…”

Section: Design and Synthesis Of The Multifunctional Pt(iv) Prodrugsmentioning

confidence: 99%