2015
DOI: 10.1530/jme-15-0232
|View full text |Cite
|
Sign up to set email alerts
|

Oxidative and endoplasmic reticulum stress in β-cell dysfunction in diabetes

Abstract: The inability of pancreatic b-cells to make sufficient insulin to control blood sugar is a central feature of the aetiology of most forms of diabetes. In this review we focus on the deleterious effects of oxidative stress and endoplasmic reticulum (ER) stress on b-cell insulin biosynthesis and secretion and on inflammatory signalling and apoptosis with a particular emphasis on type 2 diabetes (T2D). We argue that oxidative stress and ER stress are closely entwined phenomena fundamentally involved in b-cell dys… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

8
180
0
5

Year Published

2016
2016
2023
2023

Publication Types

Select...
9

Relationship

1
8

Authors

Journals

citations
Cited by 226 publications
(197 citation statements)
references
References 192 publications
(208 reference statements)
8
180
0
5
Order By: Relevance
“…Consistent with these observations, P. aeruginosa infection in mice induced lung inflammation and UPR activation as measured by splicing of XBP‐1 measured in vivo using the ERAI ER stress‐reporter transgene 49. Development of ER stress is unsurprising as CF lungs are chronically infected and the mucosa and lung secretions contain a broad array of inflammatory cytokines50, 51 many of which are known to drive oxidative stress and therefore ER stress (reviewed in Hasnain et al 1, 52…”
Section: Oxidative and Er Stress In Chronic Inflammatory And Mucopurumentioning
confidence: 73%
“…Consistent with these observations, P. aeruginosa infection in mice induced lung inflammation and UPR activation as measured by splicing of XBP‐1 measured in vivo using the ERAI ER stress‐reporter transgene 49. Development of ER stress is unsurprising as CF lungs are chronically infected and the mucosa and lung secretions contain a broad array of inflammatory cytokines50, 51 many of which are known to drive oxidative stress and therefore ER stress (reviewed in Hasnain et al 1, 52…”
Section: Oxidative and Er Stress In Chronic Inflammatory And Mucopurumentioning
confidence: 73%
“…24 Beta-cells have low intrinsic antioxidant capacity, making them vulnerable to oxidative stress which then impairs insulin biosynthesis and secretion. 25,26 Increased markers of oxidative stress are seen in serum and islets of individuals with T2D, and levels inversely correlate with the degree of insulin secretion.…”
Section: Lipotoxicitymentioning
confidence: 99%
“…The everchanging demand for insulin production and secretion in response to nutrient stimulation relies greatly on the ER, to ensure synthesis and proper folding of pro-insulin (Back et al 2009, Hassler et al 2015. As a result, β-cells are exquisitely sensitive to additional ER pressure and accumulating evidence indicate a major role of the UPR in the context of β-cell demise leading to diabetes (Brozzi & Eizirik 2016, Hasnain et al 2016.…”
Section: Introductionmentioning
confidence: 99%