Oxidative damage in gills and liver in Nile tilapia (Oreochromis niloticus) exposed to diazinon

Toledo-Ibarra, Gladys Alejandra; Díaz-Reséndiz, Karina Janice Guadalupe; Ventura-Ramón, Guadalupe Herminia; Gonzalez-Jaime, Fabiola; Vega-López, Armando; Becerril-Villanueva, Enrique; Pavón, Lenin; Girón-Pérez, Manuel Iván

doi:10.1016/j.cbpa.2016.05.007

Cited by 19 publications

(4 citation statements)

References 36 publications

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“…OPs are oxidants and impair enzymatic antioxidant defences, including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione S-transferase (GST) (23,34,44,(114)(115)(116)(117)(118)(119)(120)(121)(122)(123)(124)(125)(126)(127)(128)(129). Malathion, methyl parathion, and parathion in HepG2 cell lines, as well as chlorpyrifos, methidathion, chlorfenvinphos, and dimethoate in rat liver and diazinon in fish most probably disrupt membrane lipids through oxidative stress (23,35,61,116,118,(130)(131)(132)(133)(134)(135). Table 1 summarises the key changes in antioxidant defence and oxidative stress biomarkers caused by OPs.…”

Section: Possible Effects Of Ops On Hepatic Oxidative Stress Pathwaysmentioning

confidence: 99%

Adverse effects of organophosphorus pesticides on the liver: a brief summary of four decades of research

Karami‐Mohajeri

Ahmadipour

Rahimi

et al. 2017

Archives of Industrial Hygiene and Toxicology

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Organophosphorus pesticides (OPs) are widely used volatile pesticides that have harmful effects on the liver in acute and chronic exposures. This review article summarises and discusses a wide collection of studies published over the last 40 years reporting on the effects of OPs on the liver, in an attempt to propose general mechanisms of OP hepatotoxicity and possible treatment. Several key biological processes have been reported as involved in OP-induced hepatotoxicity such as disturbances in the antioxidant defence system, oxidative stress, apoptosis, and mitochondrial and microsomal metabolism. Most studies show that antioxidants can attenuate oxidative stress and the consequent changes in liver function. However, few studies have examined the relationship between OP structures and the severity and mechanism of their action. We hope that future in vitro, in vivo, and clinical trials will answer the remaining questions about the mechanisms of OP hepatotoxicity and its management.

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Section: Possible Effects Of Ops On Hepatic Oxidative Stress Pathwaysmentioning

confidence: 99%

Adverse effects of organophosphorus pesticides on the liver: a brief summary of four decades of research

Karami‐Mohajeri

Ahmadipour

Rahimi

et al. 2017

Archives of Industrial Hygiene and Toxicology

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“…Studies have revealed that oxidative stress can be an important component of the mechanism of DZN intoxication [1] , [28] , [66] , [69] . Treatment of rats with DZN significantly increases renal lipid peroxidation, which is accompanied by a decrease in the activity of renal antioxidant enzymes (CAT, GSH-Px, glutathione reductase and glutathione S-transferase), in addition to promoting a decrease in the level of GSH, events that may be related to the renal toxicity of DZN, mediated by oxidative stress [60] .…”

Section: Discussionmentioning

confidence: 99%

Role of biotransformation in the diazinon-induced toxicity in HepG2 cells and antioxidant protection by tetrahydrocurcumin

Miranda¹,

Beretta²,

Ferreira³

et al. 2023

Toxicology Reports

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“…Moreover, the increment in plasma urea and creatinine levels and the reduction of uric acid in plasma along with histopathological alterations of 2,4-D-treated rats reported by Tayeb et al [8] also supported the impairment of renal functions. Teratogenic [11][12][13], genotoxic [14], neurotoxic [2,[15][16][17], immunosuppressive [18], cytotoxic [19][20], and hepatotoxic [21][22][23] effects of 2,4-D have also been well documented.…”

Section: Introductionmentioning

confidence: 99%

Ameliorative Effects of Melatonin Against 2,4-Dichlorophenoxyacetic Acid Toxicity in Kidney of Mice – A Histological Study.

Upadhyaya

Rao

Jhala

2018

Asian J Pharm Clin Res

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Objective: The compound, 2,4-dichlorophenoxyacetic acid (2,4-D), is a systemic phenoxy herbicide and a plant growth regulator. Histopathological effects of 2,4-D alone and in combination with melatonin on the kidney in adult albino male mice of the Swiss strain were evaluated in the present study.Methods: Twenty adult male albino mice weighing between 30 and 40 g were assigned into four groups with five mice in each group. Group I served as control; Group II -melatonin alone (10 mg/kg body weight); Group III -2,4-D alone (50 mg/kg body weight); and Group IV -2,4-D + melatonin was given orally for 45 days.Results: It revealed a significant reduction in the body and kidney weights (p<0.001 and p<0.01 respectively) of mice treated with 2,4-D, while the body and kidney weights after treatment of melatonin and 2,4-D + melatonin were comparable to control. Histological study revealed that 2,4-D induced nephrotoxicity evidenced by various histological changes including shrinkage of the glomerulus, tubular dilation, hypertrophy of tubular epithelium, and degeneration of renal tubules. Conclusion:Treating animals with the melatonin along with 2,4-D showed mitigative effects of melatonin and minimized the structural alteration in the kidney of mice appeared due to 2,4-D toxicity.

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Oxidative damage in gills and liver in Nile tilapia (Oreochromis niloticus) exposed to diazinon

Cited by 19 publications

References 36 publications

Adverse effects of organophosphorus pesticides on the liver: a brief summary of four decades of research

Adverse effects of organophosphorus pesticides on the liver: a brief summary of four decades of research

Role of biotransformation in the diazinon-induced toxicity in HepG2 cells and antioxidant protection by tetrahydrocurcumin

Ameliorative Effects of Melatonin Against 2,4-Dichlorophenoxyacetic Acid Toxicity in Kidney of Mice – A Histological Study.

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