2009
DOI: 10.1016/j.freeradbiomed.2009.02.005
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Oxidative DNA adducts after Cu2+-mediated activation of dihydroxy PCBs: Role of reactive oxygen species

Abstract: Polychlorinated biphenyls (PCBs) are toxic industrial chemicals, complete carcinogens and efficacious tumor promoters. However, the mechanism(s) of PCB-mediated carcinogenicity remains largely undefined. One likely pathway by which these agents may play a role in carcinogenesis is the generation of oxidative DNA damage by redox cycling of dihydroxylated PCB metabolites. We have now employed a new 32 P-postlabeling system to examine novel oxidative DNA lesions induced by Cu 2+ -mediated activation of PCB metabo… Show more

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Cited by 31 publications
(40 citation statements)
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“…H 2 O 2 is known to induce oxidative stress in a variety of cells Siddiqui et al, 2011;Sattayasai et al, 2013). There is a plethora of evidence documenting the essential involvement of oxidative stress-induced damages and increased levels of H 2 O 2 in a variety of diseases (Spencer et al, 2009;Yamashita et al, 2008). Since oxidative stress seems to be involved in many diseases, the administration of anti-oxidants may be useful in the prevention and treatment of these diseases (Sekler et al, 2008).…”
Section: Discussionmentioning
confidence: 99%
“…H 2 O 2 is known to induce oxidative stress in a variety of cells Siddiqui et al, 2011;Sattayasai et al, 2013). There is a plethora of evidence documenting the essential involvement of oxidative stress-induced damages and increased levels of H 2 O 2 in a variety of diseases (Spencer et al, 2009;Yamashita et al, 2008). Since oxidative stress seems to be involved in many diseases, the administration of anti-oxidants may be useful in the prevention and treatment of these diseases (Sekler et al, 2008).…”
Section: Discussionmentioning
confidence: 99%
“…Liu et al, 2009; Lyng & Seegal, 2008). Thus, in addition to direct binding of PCBs to RyRs, PCB metabolites that possess redox active moieties, such as quinones and semiquinones (Machala et al, 2004; Spencer, Lehmler, Robertson, & Gupta, 2009), would be expected to confer additional activities toward modifying RyRs and their signaling events. In this regard, site-selective oxidation of RyRs was already demonstrated for naphthoquinones, benzoquinones, and benzo[a]pyrene 7,8-dione (Feng et al, 1999; Gao et al, 2005; Pessah et al, 2001).…”
Section: Ryr Macromolecular Complexes: Significance To Pcb-mediatementioning
confidence: 99%
“…1719,2639 Substantial evidence has accumulated to support that TCDD can induce oxidative stress in mammalian cells in vitro and in rodents in vivo. Different biomarkers have been applied to assess the oxidative stress induced by TCDD in the liver of animals including hepatic LPO, DNA single strand breaks, hepatic membrane fluidity, glutathione, nonprotein sulfhydryl, and NADPH.…”
Section: Introductionmentioning
confidence: 99%
“…Although many PHAHs have been shown to have very weak initiating activity without direct genotoxic effects, it has been postulated that they may be indirectly genotoxic through the formation of DNA lesions induced by ROS and RNS. 15,1720,2639 Because the TEF has been widely applied for the evaluation of the toxic effects of PHAHs and oxidative stress is universally induced in the animals exposed to these compounds, it is meaningful to evaluate the application of the TEF approach in the toxicity of PHAHs using DNA oxidation products, especially in chronic animal carcinogenesis studies.…”
Section: Introductionmentioning
confidence: 99%