Oxidative DNA damage and influence of genetic polymorphisms among urban and rural schoolchildren exposed to benzene

Buthbumrung, Nantaporn; Mahidol, Chulabhorn; Navasumrit, Panida; Promvijit, Jeerawan; Hunsonti, Potchanee; Autrup, Herman; Ruchirawat, Mathuros

doi:10.1016/j.cbi.2008.01.005

Cited by 64 publications

(29 citation statements)

References 44 publications

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“…The results agreed with several previous reports (Fan et al, 2012a;Buthbumrung et al, 2008). Some of the studies showed strong and positive relationships between urinary 8-OHdG concentration and PAH exposure (Lee et al, 2012;Kuang et al, 2013) and benzene exposure (Kim et al, 2006a).…”

Section: Relationships Between the 8-ohdg And Pahs And The Bt Metabolsupporting

confidence: 92%

Biomass fuels and coke plants are important sources of human exposure to polycyclic aromatic hydrocarbons, benzene and toluene

Fan

Chen³

et al. 2014

Environmental Research

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Section: Relationships Between the 8-ohdg And Pahs And The Bt Metabolsupporting

confidence: 92%

Biomass fuels and coke plants are important sources of human exposure to polycyclic aromatic hydrocarbons, benzene and toluene

Fan

Chen³

et al. 2014

Environmental Research

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“…To the best of our knowledge no substantial differences between schoolchildren and adults concerning 8-oxodG level have been reported in the literature (23,24). However, some studies have reported much lower levels of 8-oxodG than those detected in our work; for example, Buthbumrung et al (25) reported 0.8/10…”

Section: Methodscontrasting

confidence: 55%

Oxidatively Damaged DNA/Oxidative Stress in Children with Celiac Disease

Szaflarska-Popławska

Siomek²,

Czerwionka-Szaflarska³

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Because patients with celiac disease face increased risk of cancer and there is considerable circumstantial evidence that oxidatively damaged DNA may be used as a marker predictive of cancer development, we decided, for the first time, to characterize oxidative stress/oxidative DNA damage in celiac disease patients.Methods: Two kinds of oxidatively damaged DNA biomarkers, namely, urinary excretion of 8-oxodG and 8-oxoGua, and the level of oxidatively damaged DNA in the leukocytes, as well as the level of antioxidant vitamins were analyzed using high-performance liquid chromatography (HPLC) and HPLC/gas chromatography with isotope dilution mass detection methods. These parameters were determined in three groups: (a) children with untreated celiac disease, (b) patients with celiac disease on a strict gluten-free diet, and (c) healthy children.Results: The mean level of 8-oxodG in DNA isolated from the leukocytes and in the urine samples of the two groups of celiacs was significantly higher than in controls, irrespective of diet. There was no statistically significant difference in these parameters between treated and untreated celiacs. The mean plasma retinol and α-tocopherol concentration in the samples of untreated celiacs was significantly lower than in treated celiacs.Conclusion: Our results suggest that although diet can be partially responsible for oxidative stress/ oxidatively damaged DNA in celiac patients, there is a factor independent of diet.Impact: It is possible that celiac disease patients may be helped by dietary supplementation rich in vitamin A (and E) to minimize the risk of cancer development. Cancer Epidemiol Biomarkers Prev; 19(8); 1960-5. ©2010 AACR.

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“…A number of studies have shown that biomarkers of oxidative DNA damage are high in biological media, most commonly urine and blood, of adults exposed to air pollution, in particular particulate matter and benzene (32). An increment has also been found in the leucocytes, urine cells, and nasal mucosa cells of schoolchildren living in metropolitan areas, such as Bangkok (Thailand) (33) and Mexico City (34), and in the urine cells of children living near power plants in Taichung, Taiwan (35).…”

Section: Discussionmentioning

confidence: 99%

Asthma Symptoms, Lung Function, and Markers of Oxidative Stress and Inflammation in Children Exposed to Oil Refinery Pollution

et al. 2010

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Objectives. Little is known about the effects of exposure to petroleum refinery emissions on respiratory health in children. We evaluated lung function and markers of inflammation and oxidative stress in children and adolescents with and without asthma or wheezing symptoms living in a petrochemical polluted area (Sarroch, Sardinia) versus a reference area (Burcei). Methods. Parents of 275/300 6-to 14-year-old children living in Sarroch and parents of 214/323 children living in Burcei answered a questionnaire on respiratory symptoms and risk factors. Measurements of forced expiratory volume after 1 second (FEV 1 ) and of forced expiratory flow rates at 25-75% of vital capacity ) were available in 27 and 23 asthma/wheezing-positive subjects and in 7 and 54 asthma/wheezing-negative subjects in Sarroch and in Burcei, respectively; for fractional exhaled nitric oxide (FE NO ) corresponding figures were 27 and 24 and 8 and 55 in Sarroch and in Burcei, respectively. Malondialdehyde-deoxyguanosine (MDA-dG) adduct levels in nasal mucosa were measured in 12-to 14-year-old adolescents (8 and 14 asthma/wheezing-positive and 20 and 28 asthma/wheezing-negative subjects in Sarroch and in Burcei, respectively). Air pollutants were assessed during 3 weeks, starting 1 week before lung function, FE NO , and MDA-dG measurements. Generalized linear models were used to estimate the effect of the area of residence adjusting for confounders. Results. Weekly average concentrations of sulfur dioxide were 6.9-61.6 µg/m 3 in Sarroch versus 0.3-7.6 µg/m 3 in the rural area of Burcei; of nitrogen dioxide, 5.2-28.7 µg/m 3 versus 1.7-5.3 µg/m 3 ; and of benzene, 1.8-9.0 µg/m 3 versus 1.3-1.5 µg/m 3 , respectively. Children living in Sarroch versus children living in the reference area showed an increase in wheezing symptoms {adjusted prevalence ratio = 1.70 [90% confidence interval (CI) = 1.01; 2.86]}; a decrease in lung function [variation in FEV 1 = −10.3% (90% CI = −15.0; −6.0%) and in FEF 25-75 = −12.9% (90% CI = −20.7; −4.3%)]; an increase in bronchial inflammation [variation in FE NO = +35% (90% CI = 11.7; 80.1%)]; and an increase in MDA-dG adducts of +83% (90% CI = 22.9; 174.1%). Conclusions. Data from this small study are consistent with the role of environmental pollutants on lung function and inflammation.

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Oxidative DNA damage and influence of genetic polymorphisms among urban and rural schoolchildren exposed to benzene

Cited by 64 publications

References 44 publications

Biomass fuels and coke plants are important sources of human exposure to polycyclic aromatic hydrocarbons, benzene and toluene

Biomass fuels and coke plants are important sources of human exposure to polycyclic aromatic hydrocarbons, benzene and toluene

Oxidatively Damaged DNA/Oxidative Stress in Children with Celiac Disease

Asthma Symptoms, Lung Function, and Markers of Oxidative Stress and Inflammation in Children Exposed to Oil Refinery Pollution

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