Oxidative DNA damage in β-thalassemic children

El-Gindi, D Hala; Hassanin, Amal I.; Mostafa, Naglaa; Kassas, Ghada M. El; Wakeel, Maged A. El; Batal, Wael H. El; Galal, Essam M.; Elmalt, Heba A.; Amer, Marwa F.

doi:10.1097/01.mjx.0000472998.78235.d6

Cited by 7 publications

(5 citation statements)

References 22 publications

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“…The results study showed a significant serum elevation of (8-OHdG) in BMT in comparison to normal subjects. These results are in agreement with the results (El Gindi et al, 2015;Ferro et al, 2012), who found 8-OHdG was significantly increased in patients with BMT in comparison to normal control. However our results disagree with studies (El Gindi et al, 2015;Ferro et al, 2012) who found a positive correlation between 8-OHdG and ferritin in thalassemic patients.…”

Section: Discussionsupporting

confidence: 93%

Evaluation of serum trace elements, lipids profile, ferritin and 8-hydroxydeoxyguansine levels in Yemeni patients with beta thalassemia major

Al-Kobati¹,

Al-Mahbashi²,

Shamsan³

et al. 2020

Asian J Pharm Pharmacol

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Beta-thalassemia is a group of frequent genetic disorders resulting in the synthesis of little or no β-globin chains. Beta Thalassemia Major (BTM) is the most common chronic hemolytic anemia among children and adolescents worldwide (Cassinerio et al., 2012) ,most prevalent in certain malariaprone parts of the world including Africa, all Mediterranean countries, the Middle East, the Indian subcontinent, and Southeast Asia (Modell and Darlison, 2008).Patients with BTM need repeated blood transfusions for survival due to severe anemia. Recurrent blood transfusions lead to accumulation of excess iron in the body tissues. Overload of iron is responsible for lipid peroxidation and oxidative stress by increased production of reactive oxygen species within the erythrocytes (Shazia et al., 2012). Many studies showed a fluctuation in the trace elements in BTM patients that led to many complications of disease. BTM is one of the important hemoglobinopathies in Yemen and with its clinical severity; it is considered a major health problem in Yemen. The prevalence of BTM among hereditary hemoglobinopathies patients in Yemen was reported to be 13% (8.6% for α-thalassemia and 4.4% for β-thalassemia traits) in Sana'a city (Al-Nood, 2009).

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Section: Discussionsupporting

confidence: 93%

Evaluation of serum trace elements, lipids profile, ferritin and 8-hydroxydeoxyguansine levels in Yemeni patients with beta thalassemia major

Al-Kobati¹,

Al-Mahbashi²,

Shamsan³

et al. 2020

Asian J Pharm Pharmacol

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“…Oxidative stress is defined as a disturbance of the balance between production and detoxification of reactive oxygen resulting in failure to repair the subsequent damage. This disturbance can lead to harmful impacts through the formation of reactive oxygen species (ROS) leading to disruption of cellular components including nucleic acids, lipids, and proteins [17,18].…”

Section: Discussionmentioning

confidence: 99%

Urinary Markers of Oxidative Dna Damage in Type 1 Diabetic Children: Relation to Microvascular Complications

Wakeel¹,

Abou-El-Asrar²,

El-Kassas³

et al. 2017

Asian J Pharm Clin Res

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Objective: Type 1 diabetes mellitus (T1DM) is a widespread metabolic disease, which frequently carries with it a significant impact on human health. Oxidative damage and tissue inflammation have been claimed to be a typical pathogenic component for the progression of diabetic complications. We aim in this study to explore the relation of urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) (as a marker of nucleic acid oxidation) to microvascular complications in T1DM.Methods: A case–control study, enrolling 45 T1DM children and an equivalent number of healthy subjects, was performed. Full clinical examination and anthropometric measurement were performed to all subjects. Urinary assessment for 8-oxodG and albumin was done in addition to blood sampling for lipid profile and glycated Hb (HbA1c) assay. Complete ocular examination for assessment of diabetic retinopathy (DR) was also done.Results: Levels of urinary 8-oxodG, serum cholesterol, triglycerides, and low-density lipoprotein in cases were significantly higher than non-diabetics; these levels were likewise higher in uncontrolled T1DM patients in comparison with well-controlled T1DM subjects. Urinary 8-oxodG and HbA1c were significantly higher in diabetic patients with albuminuria and DR compared to patients without complications. Significant positive correlation was found between 8-oxodG with HbA1c (r=0.8, p<0.01), diastolic blood pressure (DBP) (r=0.4, p=0.02), and cholesterol (r=0.4, p=0.05).Conclusion: Urinary 8-oxodG was found to be a reliable marker for assessing oxidative DNA damage in T1DM and can be used in the determination of microvascular complications related to diabetes.

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“…From about 10,000 registered β-thalassemia cases and more than 20,000 non-registered cases; 95%of them are β-thalassemia major, and 5% are thalassemia intermediate or haemoglobin H disease [3]. β-thalassemia is a chronic condition, which put the huge psychosocial burden on the patient and his family [4], [5]. It is also considered a major health problem for the Public Health System of any country due to high expenses of treatment involving regular blood transfusions, iron chelation, frequent hospitalization and general medical follow up; that creates a burden not only on the health system but also on the affected families and their children, who become more liable to emotional, social, psychological and behavioural problems [6], [7].…”

Section: Introductionmentioning

confidence: 99%

Adaptive Functioning and Psychosocial Problems in Children with Beta Thalassemia Major

Alzaree¹,

Shehata²,

Wakeel³

et al. 2018

Open Access Maced J Med Sci

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BACKGROUND:Beta thalassemia major is considered one of the serious health problems and the commonest hemoglobinopathy in Egypt that creates a burden not only on health system but also on the affected families and children who become vulnerable to emotional, social, psychological and behavioural problems.AIM:This study was designed to assess the psychosocial burden and the adaptive functioning in children with beta-thalassemia major.SUBJECTS AND METHODS:A group of 50 children with thalassemia major and 50 normal children matched for age and sex were included in a case-control study. Vineland Adaptive Functioning Scale was used to assess the adaptive functions; while the Pediatric Symptom Checklist (PSCL) was used to assess psychosocial morbidity.RESULTS:A group of 50 children aged 5-17 years old with thalassemia major, their mean age was 11.05 ± 3.8, showed a statistically significant lower total adaptive behaviour score and communication subscale score. All the mean values of adaptive behaviour for cases and controls were within the average values. Results from the PSCL revealed no significant difference between mean scores of children with thalassemia and controls. A score of attention domain was markedly higher in children with thalassemia. Internalising behaviour was the most dominant as it was detected in 10% of the patient group.CONCLUSION:Thalassemic patients had a relatively mild affection for adaptive and psychosocial functioning that can be explained by social and medical support they receive, which may increase their competence and psychological wellbeing.

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Oxidative DNA damage in β-thalassemic children

Cited by 7 publications

References 22 publications

Evaluation of serum trace elements, lipids profile, ferritin and 8-hydroxydeoxyguansine levels in Yemeni patients with beta thalassemia major

Evaluation of serum trace elements, lipids profile, ferritin and 8-hydroxydeoxyguansine levels in Yemeni patients with beta thalassemia major

Urinary Markers of Oxidative Dna Damage in Type 1 Diabetic Children: Relation to Microvascular Complications

Adaptive Functioning and Psychosocial Problems in Children with Beta Thalassemia Major

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