Oxidative Inactivation of SARS-CoV-2 on Photoactive AgNPs@TiO2 Ceramic Tiles

Djellabi, Ridha; Parapini, S.; Delbue, Serena; D’Alessandro, Sarah; Parapini, Silvia; Cerrato, G.; Laurenti, Enzo; Falletta, Ermelinda; Bianchi, Claudia L.

doi:10.3390/ijms22168836

Cited by 21 publications

(16 citation statements)

References 51 publications

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“…Several studies have shown that AgNPs can play preventive role against SARS-CoV-2 infection and can contribute to the development of vaccines and virucides based on nanotechnology [ 36 ]. For example, in locations with severe viral or bacterial infections, such as healthcare facilities, nano-silver–modified titanium dioxide is used for self-disinfection of the environment through photocatalysis, thereby preventing the spread of SARS-CoV-2 [ 37 ]. Jeremiah et al evaluated AgNPs with different sizes and concentrations and found that 1–10 ppm of the particles with a diameter of approximately 10 nm could effectively neutralize extracellular SARS-CoV-2, and cytotoxicity was observed at >20 ppm [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Antiviral Properties of Silver Nanoparticles against SARS-CoV-2: Effects of Surface Coating and Particle Size

Lü

Liu

et al. 2022

Nanomaterials

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Coronavirus disease 2019 (COVID-19) has spread rapidly and led to over 5 million deaths to date globally. Due to the successively emerging mutant strains, therapeutics and prevention against the causative virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are urgently needed. Prevention of SARS-CoV-2 infection in public and hospital areas is essential to reduce the frequency of infections. Silver nanoparticles (AgNPs) with virucidal effects have been reported. Therefore, we investigated the virucidal activity and safety of ten types of AgNPs with different surface modifications and particle sizes, in cells exposed to SARS-CoV-2 in vitro. The AgNPs could effectively inhibit the activity of SARS-CoV-2, and different surface modifications and particle sizes conferred different virucidal effects, of which 50-nm BPEI showed the strongest antiviral effect. We concluded that the efficacy of each type of AgNP type was positively correlated with the corresponding potential difference (R2 = 0.82). These in vitro experimental data provide scientific support for the development of therapeutics against COVID-19, as well as a research basis for the development of broad-spectrum virucides. Given the increasing acquired resistance of pathogens against conventional chemical and antibody-based drugs, AgNPs may well be a possible solution for cutting off the route of transmission, either as an external material or a potential medicine.

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Section: Introductionmentioning

confidence: 99%

Antiviral Properties of Silver Nanoparticles against SARS-CoV-2: Effects of Surface Coating and Particle Size

Lü

Liu

et al. 2022

Nanomaterials

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“…However, very few studies focused on the performances of commercial air sanitizers in eliminating SARS-CoV-2 infected aerosols in indoor spaces [32]. The efficacy of photocatalytic activity against the SARS-CoV-2 virus was demonstrated using industrially coated AgNPs@TiO 2 ceramic tiles irradiated with UV-A [41]. Several studies demonstrated the virucidal activity of ozone against human respiratory viruses, such as Influenza virus [42], Influenza A and respiratory syncytial virus [43], SARS-CoV-1 [44] and other viruses [45][46][47].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Betacoronavirus OC43 and SARS-CoV-2 Elimination by Zefero Air Sanitizer Device in a Novel Laboratory Recirculation System

et al. 2022

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Indoor air sanitizers contrast airborne diseases and particularly severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)/Coronavirus disease 2019 (COVID-19). The commercial air sanitizer Zefero (Cf7 S.r.l., San Giovanni La Punta, Italy) works alternatively using a set of integrated disinfecting technologies (namely Photocatalysis/UV mode) or by generating ozone (Ozone mode). Here we evaluated the virucidal efficacy of Zefero setup modes against human Betacoronavirus OC43 and SARS-CoV-2. For this purpose, we designed a laboratory test system in which each virus, as aerosol, was treated with Photocatalysis/UV or Ozone mode and returned into a recirculation plexiglass chamber. Aerosol samples were collected after different times of exposure, corresponding to different volumes of air treated. The viral RNA concentration was determined by qRT-PCR. In Photocatalysis/UV mode, viral RNA of OC43 or SARS-CoV-2 was not detected after 120 or 90 min treatment, respectively, whereas in Ozone mode, viruses were eliminated after 30 or 45 min, respectively. Our results indicated that the integrated technologies used in the air sanitizer Zefero are effective in eliminating both viruses. As a reliable experimental system, the recirculation chamber developed in this study represents a suitable apparatus for effectively comparing the disinfection capacity of different air sanitizers.

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“…Hence, hybrid synthesis approaches may be explored to balance the toxicity (low) and stability (high) properties of AgNPs. Moreover, the silver nanoparticles and nanocomposites are currently recommended by several researchers as a potential antiviral agent to combat coronaviruses [ 18 , 229 – 231 ], which can lead to severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). These new type of viruses can cause acute respiratory distress syndrome (ARDS) and acute lung injury (ALI), which leads to pulmonary failure and/or fatality [ 232 ].…”

Section: Future Perspectivesmentioning

confidence: 99%

Synthesis approach-dependent antiviral properties of silver nanoparticles and nanocomposites

Jeevanandam

Krishnan²,

Hii

et al. 2022

J Nanostruct Chem

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Graphical abstract Numerous viral infections are common among humans, and some can lead to death. Even though conventional antiviral agents are beneficial in eliminating viral infections, they may lead to side effects or physiological toxicity. Silver nanoparticles and nanocomposites have been demonstrated to possess inhibitory properties against several pathogenic microbes, including archaea, bacteria, fungi, algae, and viruses. Its pronounced antimicrobial activity against various microbe-mediated diseases potentiates its use in combating viral infections. Notably, the appropriated selection of the synthesis method to fabricate silver nanoparticles is a major factor for consideration as it directly impacts antiviral efficacy, level of toxicity, scalability, and environmental sustainability. Thus, this article presents and discusses various synthesis approaches to produce silver nanoparticles and nanocomposites, providing technological insights into selecting approaches to generate antiviral silver-based nanoparticles. The antiviral mechanism of various formulations of silver nanoparticles and the evaluation of its propensity to combat specific viral infections as a potential antiviral agent are also discussed.

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Oxidative Inactivation of SARS-CoV-2 on Photoactive AgNPs@TiO2 Ceramic Tiles

Cited by 21 publications

References 51 publications

Antiviral Properties of Silver Nanoparticles against SARS-CoV-2: Effects of Surface Coating and Particle Size

Antiviral Properties of Silver Nanoparticles against SARS-CoV-2: Effects of Surface Coating and Particle Size

Evaluation of Betacoronavirus OC43 and SARS-CoV-2 Elimination by Zefero Air Sanitizer Device in a Novel Laboratory Recirculation System

Synthesis approach-dependent antiviral properties of silver nanoparticles and nanocomposites

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