Oxidative indices as metabolic stress predictors in periparturient dairy cows

Abstract

The aim of the study was to determine changes in reactive oxygen species (ROS), serum antioxidant capacity (SAC) and oxidative stress index (OSi; ROS/SAC) from dry off to 30 days postpartum in dairy cows. Furthermore, the relationship between indices of oxidative status (ROS, SAC, OSi) and indices related to metabolic disorders (blood free fatty acids, FFA and b-hydroxybutyrate, BHB) and a-tocopherol (a-T) was determined. Blood samples were collected from 131 dairy cows belonging to four commercial farms, located in Italy and Greece. Blood samples were collected at dry-off, calving and 30 days postpartum. Results indicated that ROS and OSi were low at dry-off and 30 days postpartum and high at calving. The serum antioxidant capacity followed exactly the opposite trend. There was a negative correlation of ROS (rho: À0.282; p .01) and OSi (rho: À0.267; p .05) with aT at all three sampling points, whereas no correlation was found between SAC and aT. Reactive oxygen species were positively correlated with BHB at all three sampling points and with FFA levels only at dry-off. A negative correlation of SAC with FFA was found at dry-off and 30 days postpartum. The oxidative stress index was positively correlated with FFA and BHB at dry-off, with FFA at calving and with BHB at 30 days postpartum. Thus, associations between parameters related to oxidative status and those related to energy balance were found, mainly at dry-off and postpartum. Oxidative stress markers determined at dry off could be useful in preventing metabolic disorders. HIGHLIGHTS Dairy cows around calving often incur metabolic disorders. Associations between oxidative and metabolic markers were found mainly at dry-off and postpartum. Oxidative markers could be used as a tool for metabolic disorders prevention.

Comparison of metabolic, oxidative and inflammatory status of Simmental × Holstein crossbred with parental breeds during the peripartal and early lactation periods

“…Recently, Invernizzi et al . (2019) observed significant differences in d-ROMs and OSi parameters across the periparturient period, meaning that they may be considered useful biomarkers for oxidative stress.…”

Toxoplasma gondii'li koyunlarda Oksidatif Stresin Glutatyon, Malondialdehit Düzeyi, Oksidatif Stres İndeksi, Toplam Oksidan Durumu ve Toplam Antioksidan Kapasitesi Kullanılarak Değerlendirilmesi

“…According to Durgut et al (2016) in cattle with abomasum displacement, they found that OSI level was significantly greater in cattle with right displacement compared to with left displacement and healthy cattle. Invernizzi et al (2019) found in a study they conducted that the OSI level at the calving time was higher than the dry period and the 30th day after calving. Durgut et al (2013) did not find any difference between the OSI levels of bovine herpes virus-1 infected cattle and healthy cattle.…”

How to manage cows yielding 20,000 kg of milk: technical challenges and environmental implications

“…They stated that the effect of genetic, nutritional, and management strategies on periparturient cow wellbeing cannot be assessed without appropriate tools for measuring metabolic health at both the individual and herd levels especially measuring these parameters from plasma and milk that have strong associations with economically important outcomes related to metabolic health in early lactation, such as disease occurrence, milk yield, and reproductive performance. Furthermore, markers of oxidative status can predict the cow stress and support nutritional choices (Invernizzi et al 2019). Oxidative stress must be monitored separately since often it has no clear relationships with plasma NEFA or BHB, suggesting that inflammatory status can be altered without direct associations with indicators of energy metabolism (Overton et al 2017).…”