Oxidative, inflammatory, genetic, and epigenetic biomarkers associated with chronic obstructive pulmonary disorder

Aggarwal, Taru; Wadhwa, Ridhima; Thapliyal, Noopur; Sharma, Kanishka; Rani, Varsha; Maurya, Pawan Kumar

doi:10.1002/jcp.27181

Cited by 15 publications

(10 citation statements)

References 166 publications

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“…Indeed, biomass fuels’ smoke has been identified as an independent risk factor leading to the development of COPD, particularly in low- and middle-income countries highly dependent on the use of biomass fuels [ 3 ]. COPD comprises of two diseases, emphysema and chronic bronchitis, whereby an abnormal inflammatory response in the lungs occurs after exposure to noxious particles or gases, leading to airway obstruction and emphysematous changes [ 4 ]. Symptoms of COPD are commonly chronic cough, excessive mucus production, air trapping, dynamic hyperinflation and shortness of breath upon physical exertion [ 1 , 3 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Extracellular vesicles and chronic obstructive pulmonary disease (COPD): a systematic review

et al. 2022

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Background Chronic Obstructive Pulmonary Disease (COPD) is a common inflammatory disease of the airways characterized by irreversible airflow limitation, ranking the third highest cause of death worldwide. Extracellular vesicles (EVs) are important intercellular communication mediators released by cells into their extracellular environment with the capacity to transfer biological signals. EVs involved in COPD hold great potential to understand disease pathogenesis and identify important biomarkers. This systematic review aims to examine all available research on EVs in the pathogenesis and diagnosis of COPD to identify existing knowledge and support further research within the field. Methods Publications were searched using PubMed and EMBASE with the search terms (Exosomes or extracellular vesicles or microvesicles or microparticles or ectosomes) AND (chronic obstructive pulmonary disease or COPD or emphysema or bronchitis). Results Initial search yielded 512 papers of which 142 were manually selected for review and 43 were eligible for analyses. The studies were divided into groups according to the role of EVs in pathogenesis, EV origin and cargo, their role in COPD exacerbations and their diagnostic utility. EVs were found to be involved in the mechanism of pathogenesis of COPD, derived from various cell types, as well as containing modified levels of miRNAs. EVs also varied according to the pathophysiological status of disease, therefore presenting a possible method for COPD diagnosis and progress monitoring. Conclusion The current findings show the limited but good quality research looking at the role of EVs in COPD, demonstrating the need for more studies to better define and provide further insight into the functional characteristics of EV in COPD pathogenesis.

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Section: Introductionmentioning

confidence: 99%

Extracellular vesicles and chronic obstructive pulmonary disease (COPD): a systematic review

et al. 2022

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“…Inflammation and oxidative stress play a pivotal role in the pathogenesis of various lung disorders [ 180 ] such as asthma, chronic obstructive pulmonary disease (COPD) [ 181 ], pulmonary fibrosis (PF), acute lung injury (ALI), and lung cancer [ 182 ]. Certain herbal remedies are of significant value in the treatments of pulmonary diseases.…”

Section: Benefits Of Black Cumin On Human Health and Disease Conditionsmentioning

confidence: 99%

Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety

et al. 2021

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Mounting evidence support the potential benefits of functional foods or nutraceuticals for human health and diseases. Black cumin (Nigella sativa L.), a highly valued nutraceutical herb with a wide array of health benefits, has attracted growing interest from health-conscious individuals, the scientific community, and pharmaceutical industries. The pleiotropic pharmacological effects of black cumin, and its main bioactive component thymoquinone (TQ), have been manifested by their ability to attenuate oxidative stress and inflammation, and to promote immunity, cell survival, and energy metabolism, which underlie diverse health benefits, including protection against metabolic, cardiovascular, digestive, hepatic, renal, respiratory, reproductive, and neurological disorders, cancer, and so on. Furthermore, black cumin acts as an antidote, mitigating various toxicities and drug-induced side effects. Despite significant advances in pharmacological benefits, this miracle herb and its active components are still far from their clinical application. This review begins with highlighting the research trends in black cumin and revisiting phytochemical profiles. Subsequently, pharmacological attributes and health benefits of black cumin and TQ are critically reviewed. We overview molecular pharmacology to gain insight into the underlying mechanism of health benefits. Issues related to pharmacokinetic herb–drug interactions, drug delivery, and safety are also addressed. Identifying knowledge gaps, our current effort will direct future research to advance potential applications of black cumin and TQ in health and diseases.

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“…Epigenetic modifications refer to alteration in the gene expression pattern which may be due to histone modification, DNA methylation, gene silencing by Noncoding RNA, an aberration in chromatin and DNA occurring due to environmental influences (Handy, Castro, & Loscalzo, 2011). Evidence suggested that epigenetic changes associated with COPD include DNA methylation at specific CpG Islands as mentioned in Table 3, these studies are based on analysis of blood sample for genotyping (Aggarwal, Wadhwa, Thapliyal et al, 2018)…”

Section: Epigenetic Modifications In Copdmentioning

confidence: 99%

Identification of biomarkers and genetic approaches toward chronic obstructive pulmonary disease

Wadhwa

Aggarwal

Malyla

et al. 2019

Journal Cellular Physiology

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Chronic obstructive pulmonary disease accounts as the leading cause of mortality worldwide prominently affected by genetic and environmental factors. The disease is characterized by persistent coughing, breathlessness airways inflammation followed by a decrease in forced expiratory volume1 and exacerbations, which affect the quality of life. Determination of genetic, epigenetic, and oxidant biomarkers to evaluate the progression of disease has proved complicated and challenging. Approaches including exome sequencing, genome‐wide association studies, linkage studies, and inheritance and segregation studies played a crucial role in the identification of genes, their pathways and variation in genes. This review highlights multiple approaches for biomarker and gene identification, which can be used for differential diagnosis along with the genome editing tools to study genes associated with the development of disease and models their function. Further, we have discussed the approaches to rectify the abnormal gene functioning of respiratory tissues and various novel gene editing techniques like Zinc finger nucleases (ZFN), transcription activator‐like effector nucleases (TALEN), and clustered regulatory interspaced short palindromic repeats/CRISPR‐associated protein 9 (CRISPR/Cas9).

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Oxidative, inflammatory, genetic, and epigenetic biomarkers associated with chronic obstructive pulmonary disorder

Cited by 15 publications

References 166 publications

Extracellular vesicles and chronic obstructive pulmonary disease (COPD): a systematic review

Extracellular vesicles and chronic obstructive pulmonary disease (COPD): a systematic review

Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety

Identification of biomarkers and genetic approaches toward chronic obstructive pulmonary disease

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