Oxidative modification of proteins and blood antioxidant activity of ground squirrels during induced awakening from hibernation

Astaeva, M. D.; Klichkhanov, N. K.

doi:10.1134/s106235900906003x

Cited by 3 publications

(3 citation statements)

References 32 publications

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“…Buzadźić et al (1990a, b) suggested that high antioxidant defence in hibernators was a consequence of NST in BAT, especially during rewarming from hibernation torpor. An increased concentration of antioxidants during hibernation bout and also during rewarming phase would protect against oxidative stress during arousal, when metabolic rate dramatically increased (Buzadźić et al 1990a, b;Tøien et al 2001;Ma et al 2005;Okamoto et al 2006;Filho et al 2007;Morin and Storey 2007;Astaeva and Klichkhanov 2009;Vucetic et al 2013;Yin et al 2016; but see Page et al 2009). Although rewarming may increase the amount of carbonyl proteins and lipid peroxide end products in BAT, indicating oxidative stress in this tissue, nonetheless hibernation torpor itself did not induce oxidative stress (Orr et al 2009).…”

Section: Seasonal Changes In Antioxidant Defencementioning

confidence: 95%

Predictive and reactive changes in antioxidant defence system in a heterothermic rodent

2020

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Living in a seasonal environment requires periodic changes in animal physiology, morphology and behaviour. Winter phenotype of small mammals living in Temperate and Boreal Zones may differ considerably from summer one in multiple traits that enhance energy conservation or diminish energy loss. However, there is a considerable variation in the development of winter phenotype among individuals in a population and some, representing the non-responding phenotype (non-responders), are insensitive to shortening days and maintain summer phenotype throughout a year. Differences in energy management associated with the development of different winter phenotypes should be accompanied by changes in antioxidant defence capacity, leading to effective protection against oxidative stress resulting from increased heat production in winter. To test it, we analysed correlation of winter phenotypes of Siberian hamsters (Phodopus sungorus) with facultative non-shivering thermogenesis capacity (NST) and oxidative status. We found that in both phenotypes acclimation to winter-like conditions increased NST capacity and improved antioxidant defence resulting in lower oxidative stress (OS) than in summer, and females had always lower OS than males. Although NST capacity did not correlate with the intensity of OS, shortly after NST induction responders had lower OS than non-responders suggesting more effective mechanisms protecting from detrimental effects of reactive oxygen metabolites generated during rewarming from torpor. We suggest that seasonal increase in antioxidant defence is programmed endogenously to predictively prevent oxidative stress in winter. At the same time reactive upregulation of antioxidant defence protects against reactive oxygen species generated during NST itself. It suggests that evolution of winter phenotype with potentially harmful characteristics was counterbalanced by the development of protective mechanisms allowing for the maintenance of phenotypic adjustments to seasonally changing environment.

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Section: Seasonal Changes In Antioxidant Defencementioning

confidence: 95%

Predictive and reactive changes in antioxidant defence system in a heterothermic rodent

2020

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“…Функціонування СОД у клітинах еукаріотів пов'язано з існуванням таких ізоформ: цитозольної Сu,Zn-СОД (у вигляді мономеру 29-32 кДа та димеру 61-64 кДа) та мітохондріальної Mn-СОД (тетрамер 76-81 кДа) [ може забезпечувати стійкість організму до окисного стресу, у тому числі і при виході тварин із стану гібернації [18].…”

Section: результати та їх обговоренняunclassified

Аntioxidant Defense System State in the Liver and the Myocardium of Rats Under Conditions of Acute Hypoxia-Hypercapnia

Khyzhnyak¹,

Morozova²,

Мидык³

et al. 2019

Fiziol Zh

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Проведена оцінка антиоксидантного статусу тканин щура за умов гострої гіпоксії-гіперкапнії при зниженні температури тіла. Встановлене зниження вмісту активних продуктів 2-тіобарбітурової кислоти (ТБК-АП) в печінці та міокарді на 48,2 та 51,0% відповідно свідчить про пригнічення окисних процесів у тканинах. При цьому в печінці активність супероксиддисмутази (СОД) знижувалася на 24,2%, переважно за рахунок молекулярної форми Сu,Zn-СОД, а каталази зростала на 29,4%. У міокарді активність СОД зростала на 62,7 %, переважно за рахунок молекулярної форми Mn-СОД, а каталази зменшувалася на 21,9%. Досліджувані показники відновлювалися до контрольних значень через 24 год після зняття впливу гіпоксії-гіперкапнії. Показано різноспрямовані зміни активності глутатіонпероксидази та вмісту відновленого глутатіону в тканинах щурів в умовах досліду. Зроблено висновок, що у разі гострої гіпоксії-гіперкапнії перебіг окисних процесів у організмі щурів знаходиться під контролем системи антиоксидантного захисту. Обговорюється можлива регуляторна роль гіперкапнії.

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“…Along with numerous studies on torpid ground squirrels (Sciuridae) (Toien et al, 2001;Carey et al, 2003;Astaeva and Klichkhanov, 2009;Orr et al, 2009;Storey, 2010;James et al, 2013) there are very few data on the antioxidant status in bats (Wilhelm Filho et al, 2007;Lilley et al, 2014;Yin et al, 2016). Some authors (Wilhelm Filho et al, 2007;Yin et al, 2016) consider that bats are likely to cope with oxidative stress through effective antioxidant defenses during hibernation.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant defenses in three vesper bats(Chiroptera: Vespertilionidae) during hibernation

Antonova¹,

Ilyukha²,

Sergina³

et al. 2017

Turk J Zool

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IntroductionMammalian hibernators represent a unique model for the study of adaptation to changes in oxygen consumption (Carey et al., 2003;van Breukelen and Martin, 2015). Physiological parameters such as metabolism and oxygen supply are reduced during torpor (Storey, 2010;Yin et al., 2016). However, torpor is replaced by periods of intensive metabolic activity (arousal), which are characterized by quick warming of the organism (Carey et al., 2003;Storey, 2010). The great burst of reactive oxygen species (ROS) in mitochondrial respiration during the torpor-arousal cycles of bats may lead to the oxidative damage to sensitive tissues (Carey et al., 2003;Sanderson et al., 2013;Yin et al., 2016). The glutathione (GSH) and antioxidant defense enzymes (superoxide dismutase (SOD) and catalase) reduce the effects of ROS (Galano and Alvarez-Idaboy, 2011; Conde-Pérezprina et al., 2012).Along with numerous studies on torpid ground squirrels (Sciuridae)

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Oxidative modification of proteins and blood antioxidant activity of ground squirrels during induced awakening from hibernation

Cited by 3 publications

References 32 publications

Predictive and reactive changes in antioxidant defence system in a heterothermic rodent

Predictive and reactive changes in antioxidant defence system in a heterothermic rodent

Аntioxidant Defense System State in the Liver and the Myocardium of Rats Under Conditions of Acute Hypoxia-Hypercapnia

Antioxidant defenses in three vesper bats(Chiroptera: Vespertilionidae) during hibernation

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