Oxidative/Nitrosative Stress in Patients With Modic Changes

Kurutaş, Ergül Belge; Şenoğlu, Mehmet; Yüksel, Kasım Zafer; Ünsal, Velid; Altun, İdris

doi:10.1097/brs.0000000000000737

Cited by 17 publications

(12 citation statements)

References 27 publications

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“…However, when free radical generation exceeds the antioxidant production capacity, oxidative stress occurs in various diseases [ 15 ]. Recently, there has been considerable interest in oxidative stress caused by ROS and its involvement in disease processes [ 16 , 17 ]. The results of the present study showed that 8-iso-PGF 2α (lipid peroxidation product) level was significantly higher in lesional area compared to non-lesional area.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of local trace element status and 8-Iso-prostaglandin F2α concentrations in patients with Tinea pedis

et al. 2016

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BackgroundTinea pedis (TP) is an infection of the feet caused by fungi. The infectious diseases caused by dermatophytes are mainly related to the enzymes produced by these fungi. Up to the now, the local 8-iso-prostaglandin F2α (8-iso-PGF2α), concentration as oxidative stress biomarker and trace elements status have not been published in patients with TP. The aim of this study is to evaluate the relationship between oxidative stress and trace elements (Cu, Zn, Se), and to evaluate the ratios of Cu/Zn and Cu/Se in this disorder.MethodsForty-three consecutive patients with a diagnosis of unilateral interdigital TP were enrolled in this study. The samples were obtained by scraping the skin surface. 8-iso-PGF2α concentrations in scraping samples were determined by ELISA. In addition, the levels of Se, Zn and Cu in scraping samples were determined on flame and furnace atomic absorption spectrophotometer using Zeeman background correction.ResultsOxidative stress was confirmed by the significant elevation in 8-iso-PGF2α concentrations (p < 0.05). When compared to non-lesional area, Zn and Se levels were significantly lower on lesional area, whereas Cu levels was higher on the lesional area than the non-lesional area (p < 0.05). In addition, the correlation results of this study were firstly shown that there were significant and positive correlations between Cu and 8-iso-PGF2α parameters, but negative correlations between Se-Cu; Se-8-iso-PGF2α parameters in lesional area. Furthermore, the ratios of Cu/Zn and Cu/Se were significantly higher on the lesional area than the non-lesional area (p < 0.05). According to sex and fungal subtypes, there was no significant difference in the concentrations of 8-iso-PGF2α and trace elements in patients with TP (p > 0.05).ConclusionsOur results showed that there is a possible link between oxidative stress (increased 8-iso-PGF2α concentrations) and imbalanced of trace elements status in lesional area of TP patients. The use of antifungal agents together with both Zn and Se drugs could be helpful in the both regression of disease and in shortening the duration of disease.

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Section: Discussionmentioning

confidence: 99%

Evaluation of local trace element status and 8-Iso-prostaglandin F2α concentrations in patients with Tinea pedis

et al. 2016

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“…Therefore, biological therapy is a potential method for the treatment of IDD, which can avoid the complication of surgery. Numerous researches have shown that oxidative stress participated in the pathological process of IDD [26–30, 37]. However, the underpinning molecular mechanism is only partially elucidated.…”

Section: Discussionmentioning

confidence: 99%

“…Another study revealed that the level of oxidative stress in the degeneration of cartilaginous endplate was increased, which indicated that oxidative stress was also involved in the degeneration of cartilaginous endplate [30]. Nonetheless, no study was designed to explore the autophagy and apoptosis of cartilaginous endplate under oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Autophagy Is a Protective Response to the Oxidative Damage to Endplate Chondrocytes in Intervertebral Disc: Implications for the Treatment of Degenerative Lumbar Disc

Chen

et al. 2017

Oxidative Medicine and Cellular Longevity

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Low back pain (LBP) is the leading cause of disability in the elderly. Intervertebral disc degeneration (IDD) was considered as the main cause for LBP. Degeneration of cartilaginous endplate was a crucial harmful factor during the initiation and development of IDD. Oxidative stress was implicated in IDD. However, the underlying molecular mechanism for the degeneration of cartilaginous endplate remains elusive. Herein, we found that oxidative stress could induce apoptosis and autophagy in endplate chondrocytes evidenced by western blot analysis, flow cytometry, immunofluorescence staining, GFP-LC3B transfection, and MDC staining. In addition, we also found that the apoptosis of endplate chondrocytes was significantly increased after the inhibition of autophagy by bafilomycin A1 shown by flow cytometry. Furthermore, mTOR pathway upstream autophagy was greatly suppressed suggested by western blot assay. In conclusion, our study strongly revealed that oxidative stress could increase autophagy and apoptosis of endplate chondrocytes in intervertebral disc. The increase of autophagy activity could prevent endplate chondrocytes from apoptosis. The autophagy in endplate chondrocytes induced by oxidative stress was mTOR dependent. These findings might shed some new lights on the mechanism for IDD and provide new strategies for the treatments of IDD.

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“…In some cases, the invading bacteria may have a nonskin origination, for example, from the oral cavity, as shown by Rollason et al . in a phylogenetic study [20];The most commonly found bacteria in the disc and herniated discal tissue are different subtypes of P. acnes [20–22];Bacteria with sufficiently virulent characteristics are able to colonize intradiscally [10];This is followed by inflammation and accelerated degeneration that in turn leads to end plate damage and MC changes as seen on MRI scans [10,23,24];Disc-related inflammation will lead to back pain and the injection of anti-inflammatory agents has demonstrated short-term pain reduction in several studies [23,25];A long-term antibiotic regimen results in a 50% reduction of pain in 50% of patients with low back pain following a disc herniation and Modic changes type 1 [12,13]. …”

Section: The Infectious Pathway: the Scientific Casementioning

confidence: 99%

“…This is followed by inflammation and accelerated degeneration that in turn leads to end plate damage and MC changes as seen on MRI scans [10,23,24];…”

Section: The Infectious Pathway: the Scientific Casementioning

confidence: 99%

10 Years of Research: From Ignoring Modic Changes to Considerations Regarding Treatment and Prevention of Low-Grade Disc Infections

Manniche

Jordan

2016

Future Sci. OA

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Oxidative/Nitrosative Stress in Patients With Modic Changes

Abstract: 4.

Cited by 17 publications

References 27 publications

Evaluation of local trace element status and 8-Iso-prostaglandin F2α concentrations in patients with Tinea pedis

Evaluation of local trace element status and 8-Iso-prostaglandin F2α concentrations in patients with Tinea pedis

Autophagy Is a Protective Response to the Oxidative Damage to Endplate Chondrocytes in Intervertebral Disc: Implications for the Treatment of Degenerative Lumbar Disc

10 Years of Research: From Ignoring Modic Changes to Considerations Regarding Treatment and Prevention of Low-Grade Disc Infections

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