Oxidative potential of fine ambient particles in various environments

Borlaza, Lucille Joanna S.; Cosep, Enrique Mikhael R.; Kim, Seojong; Lee, Kwangyul; Joo, Hung-Soo; Park, Minhan; Bate, Daphne; Cayetano, Mylene G.; Park, Kihong

doi:10.1016/j.envpol.2018.09.074

Cited by 70 publications

(41 citation statements)

References 64 publications

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“…14,19,20 First, air pollutants can produce free reactive oxygen species, which can activate the nuclear factor kappaB, leading to increased pro-inflammatory cytokines, including TNF-α, ultimately resulting in chronic lung and systemic inflammation. 21–23 Second, oxidative stress and local lung injury can influence T and B cells and thereby regulate regulatory T cells and Th17 cells. Third, diesel exhaust particles can affect cell viability, inducing autophagy, apoptosis and necrosis.…”

Section: Discussionmentioning

confidence: 99%

Effect of air pollution on hospital admissions for systemic lupus erythematosus in Bengbu, China: a time series study

Zhao

Mei

et al. 2019

Lupus

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Recently, exposure to air pollutants has been associated with the development and progression of systemic lupus erythematosus (SLE). The current study aims to evaluate the effects of air pollutants on SLE hospital admissions in Bengbu, China. We performed distributed lag non-linear model combined with quasi-Poisson generalized linear regression to assess the impacts of air pollutants on SLE admissions from 2015 to 2017. Subgroup analyses by admission status (first admission or readmission) were also evaluated. A total of 546 hospital admissions during 2015–2017 were included. For single-day lag structures, the risk effects occurred from lag 2 to lag 9 for the 75th percentile particulate matter (PM)2.5, lag 3 to lag 9 for the 80th percentile PM2.5. For cumulative lag structures, the risk effects occurred from lag 0–5 to lag 0–14 for both 75th PM2.5 and 80th PM2.5, and no significant effect was observed for 90th PM2.5. In addition, the adverse effects on SLE first admissions occurred from lag 0 to lag 1 for NO2, lag 1 to lag 2 for SO2. The maximum effect of PM2.5 on SLE was 4.27 (95% confidence interval: 1.34–13.59) at lag 0–13 day, the minimum effect value was 1.12 (95% confidence interval: 1.03–1.23) at lag 9 day. These findings demonstrate that high PM2.5, NO2 and SO2 are associated with SLE hospital admissions. In addition, this study further revealed that exposure to high concentration of PM2.5 increased the risk of SLE relapse, while high levels of NO2 and SO2 increased the risk of SLE first admissions.

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Section: Discussionmentioning

confidence: 99%

Effect of air pollution on hospital admissions for systemic lupus erythematosus in Bengbu, China: a time series study

Zhao

Mei

et al. 2019

Lupus

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“…The Gwangju site in Korea is located on the campus of the Gwangju Institute of Science and Technology (GIST) (35 • 13 41.1 N and 126 • 50 36.3 E). The Gwangju site is situated~8 km from the city center and is surrounded by agricultural, residential, and commercial areas and is also close to a main highway [20]. The sampling and measurements of PM 2.5 were simultaneously conducted from Jan 3, 2018 to Feb 2, 2018 in both sites.…”

Section: Experimental Methodsmentioning

confidence: 99%

“…Long-term measurements of the chemical composition of PM 2.5 at specific sites have been useful to examine seasonal and annual variability of PM 2.5 sources. Additionally, spatial variability in the chemical composition of PM 2.5 in regions of varying land use in each country was investigated to determine the source variability at different locations [6,[19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Measurements of Chemical Compositions of Fine Particles during Winter Haze Period in Urban Sites in China and Korea

et al. 2020

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We performed simultaneous measurements of chemical compositions of fine particles in Beijing, China and Gwangju, Korea to better understand their sources during winter haze period. We identified PM2.5 events in Beijing, possibly caused by a combination of multiple primary combustion sources (biomass burning, coal burning, and vehicle emissions) and secondary aerosol formation under stagnant conditions and/or dust sources under high wind speeds. During the PM2.5 events in Gwangju, the contribution of biomass burning and secondary formation of nitrate and organics to the fine particles content significantly increased under stagnant conditions. We commonly observed the increases of nitrogen-containing organic compounds and biomass burning inorganic (K+) and organic (levoglucosan) markers, suggesting the importance of biomass burning sources during the winter haze events (except dust event cases) at both sites. Pb isotope ratios indicated that the fraction of Pb originated from possibly industry and coal combustion sources increased during the PM2.5 events in Gwangju, relative to nonevent days.

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“…The dithiothreitol (DTT) and ascorbic-acid (AA) assays are widely used in associations with health endpoints (Abrams et al, 2017;Atkinson et al, 2016;Bates et al, 2015;Canova et al, 2014;Fang et al, 2016;Janssen et al, 2015;Strak et al, 2017a;Weichenthal et al, 2016;Yang et al, 2016;Zhang et al, 2016) even if the exact methodologies differ from one study to the other. Results can also differ for the seasonality of OP based on these two assays and some studies report strong seasonality of OP whereas others don't (Bates et al, 2015;Calas et al, 2019;Cesari et al, 2019;Fang et al, 2016;Ma et al, 2018;Paraskevopoulou et al, 2019;Perrone et al, 2016;Pietrogrande et al, 2018;Verma et al, 2014;Fang et al, 2015;Weber et al, 2018;Borlaza et al, 2018;Zhou et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Source apportionment of atmospheric PM<sub>10</sub> Oxidative Potential: synthesis of 15 year-round urban datasets in France

Weber¹,

Uzu²,

Favez³

et al. 2021

Preprint

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Abstract. Reactive oxygen species (ROS) carried or induced by particulate matter (PM) are suspected to induce oxidative stress in vivo, leading to adverse health impacts, such as respiratory or cardiovascular diseases. The oxidative potential (OP) of PM, displaying the ability of PM to oxidize the lung environment, is gaining a strong interest to examine health risks associated to PM exposure. In this study, OP was measured by two different acellular assays (dithiothreitol, DTT and ascorbic acid, AA) on PM10 filter samples from 15 yearly time series of filters collected at 14 different locations in France between 2013 and 2018, including urban, traffic and Alpine valley site typologies. A detailed chemical speciation was also performed on the same samples allowing the source-apportionment of PM using positive matrix factorization (PMF) for each series, for a total number of more than 1700 samples. This study provides then a large-scale synthesis on the source-apportionment of OP using coupled PMF and multiple linear regression (MLR) models. The primary road traffic, biomass burning, dust, MSA-rich, and primary biogenic sources had distinct positive redox-activity towards the OPDTT assay, whereas biomass burning and road traffic sources only display significant activity for the OPAA assay. The daily median source contribution to the total OPDTT highlighted the dominant influence of the primary road traffic source. Both the biomass burning and the road traffic sources contributed evenly to the observed OPAA. Therefore, it appears clearly that residential wood burning and road traffic are the two main target sources to prioritized in order to decrease significantly the OP in Western Europe and, would the OP being a good proxy of human health impact, to lower the health risks from PM exposure.

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Oxidative potential of fine ambient particles in various environments

Cited by 70 publications

References 64 publications

Effect of air pollution on hospital admissions for systemic lupus erythematosus in Bengbu, China: a time series study

Effect of air pollution on hospital admissions for systemic lupus erythematosus in Bengbu, China: a time series study

Simultaneous Measurements of Chemical Compositions of Fine Particles during Winter Haze Period in Urban Sites in China and Korea

Source apportionment of atmospheric PM<sub>10</sub> Oxidative Potential: synthesis of 15 year-round urban datasets in France

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Oxidative potential of fine ambient particles in various environments

Cited by 70 publications

References 64 publications

Effect of air pollution on hospital admissions for systemic lupus erythematosus in Bengbu, China: a time series study

Effect of air pollution on hospital admissions for systemic lupus erythematosus in Bengbu, China: a time series study

Simultaneous Measurements of Chemical Compositions of Fine Particles during Winter Haze Period in Urban Sites in China and Korea

Source apportionment of atmospheric PM&lt;sub&gt;10&lt;/sub&gt; Oxidative Potential: synthesis of 15 year-round urban datasets in France

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Source apportionment of atmospheric PM<sub>10</sub> Oxidative Potential: synthesis of 15 year-round urban datasets in France