Oxidative stability of linseed oil nano-emulsions filled in calcium alginate hydrogels

Rahiminezhad, Zahra; Gahruie, Hadi Hashemi; Esteghlal, Sara; Mesbahi, Gholamreza; Golmakani, Mohammad‐Taghi; Hosseini, Seyed Mohammad Hashem

doi:10.1016/j.lwt.2020.109392

Cited by 26 publications

(15 citation statements)

References 59 publications

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“…The stability is due to sufficient mutual electrostatic repulsion. This principle is effective for surfactants that have low molecular weights and pure electric stabilization and not for high-molecular-weight stabilizers that act by steric stabilization [ 24 , 25 ]. Therefore, in the present study, despite the measured potential value of nanohydrogel, i.e., −19.3 mV, the natural polymer generated the additional steric repulsive force that adsorbed onto the particle surface of the nanohydrogel and enabled it to exhibit good stability, which was in line with findings reported by Wu et al [ 26 , 27 ].…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial and Anti-Inflammatory Activity of Low-Energy Assisted Nanohydrogel of Azadirachta indica Oil

Kaur

Sharma

Bains

et al. 2022

Gels

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Plant-based bioactive compounds have been utilized to cure diseases caused by pathogenic microorganisms and as a substitute to reduce the side effects of chemically synthesized drugs. Therefore, in the present study, Azadirachta indica oil nanohydrogel was prepared to be utilized as an alternate source of the antimicrobial compound. The total phenolic compound in Azadirachta indica oil was quantified by chromatography analysis and revealed gallic acid (0.0076 ppm), caffeic acid (0.077 ppm), and syringic acid (0.0129 ppm). Gas chromatography–mass spectrometry analysis of Azadirachta indica oil revealed the presence of bioactive components, namely hexadecenoic acid, heptadecanoic acid, ç-linolenic acid, 9-octadecanoic acid (Z)-methyl ester, methyl-8-methyl-nonanoate, eicosanoic acid, methyl ester, and 8-octadecane3-ethyl-5-(2 ethylbutyl). The nanohydrogel showed droplet size of 104.1 nm and −19.3 mV zeta potential. The nanohydrogel showed potential antimicrobial activity against S. aureus, E. coli, and C. albicans with minimum inhibitory, bactericidal, and fungicidal concentrations ranging from 6.25 to 3.125 (µg/mL). The nanohydrogel showed a significantly (p < 0.05) higher (8.40 log CFU/mL) value for Gram-negative bacteria E. coli compared to Gram-positive S. aureus (8.34 log CFU/mL), and in the case of pathogenic fungal strain C. albicans, there was a significant (p < 0.05) reduction in log CFU/mL value (7.79–6.94). The nanohydrogel showed 50.23–82.57% inhibition in comparison to standard diclofenac sodium (59.47–92.32%). In conclusion, Azadirachta indica oil nanohydrogel possesses great potential for antimicrobial and anti-inflammatory activities and therefore can be used as an effective agent.

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Section: Resultsmentioning

confidence: 99%

Antimicrobial and Anti-Inflammatory Activity of Low-Energy Assisted Nanohydrogel of Azadirachta indica Oil

Kaur

Sharma

Bains

et al. 2022

Gels

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“…As a comparison, the encapsulation rate of loaded-LEO β-cyclodextrin, a traditional encapsulated material for hydrophobic drugs, was only 68.98 ± 2.58%, suggesting that C 13 -VY, C 13 -WY, and C 13 -YY hydrogels could be efficient candidates for LEO embedding. Researchers designed materials to encapsulate and load essential oils, but the loading rate was usually approximately 80% less than that of peptide hydrogels. , Moreover, it can also be found that LEO embedding rate was positively associated with the rigidity and uniform nanofiber structures, whereas C 13 -YY hydrogels with the highest G′ value and denser nanofiber networks showed the greatest encapsulation rate of LEO. The higher loading ability of LEO in hydrogels might be attributed to the dual mechanisms of noncovalent interactions and the entanglement nanofibers that effectively locked the LEO within the molecules …”

Section: Resultsmentioning

confidence: 99%

Sequence-Selected C₁₃-Dipeptide Self-Assembled Hydrogels for Encapsulation of Lemon Essential Oil with Antibacterial Activity

Yang

et al. 2022

J. Agric. Food Chem.

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Supramolecular self-assembling peptide hydrogels are attracting attention. The switching of even one amino acid may lead to differences in structure and functions of peptide hydrogels. Herein, we investigate the effect of substitution of a single amino acid residue on the gelation properties of C 13 -dipeptide hydrogels. We show that four C 13 -R 1 Y (C 13 -VY, C 13 -FY, C 13 -WY, and C 13 -YY) can form hydrogels with drastically tunable rigidity (the G′ values were 5. 74, 0.16, 27.74, and 67.90 KPa, respectively). Moreover, C 13 -WY and C 13 -YY hydrogels with high stability and excellent mechanical properties formed β-sheet nanofiber crosslinked networks. Furthermore, we applied four hydrogels into encapsulation of lemon essential oil (LEO). The peptide hydrogels had a high encapsulation rate and slowly released the LEO. Importantly, the LEO-loaded hydrogels showed enhanced antibacterial activity than free LEO. Our results clearly demonstrate the significance of side-chain interactions in determining hydrogel properties and their potential application in encapsulation for nutrition agents and hydrophobic drugs.

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“…It is known that the degree of deformation of gel microspheres under the action of applied external force is related to the particle size, number of layers, SA concentration and shell thickness [ 40 ], as shown in Table 1 . The hardness and springiness of the gel microspheres increased with the concentration of SA and the increase in the number of layers, mainly due to the increase in the degree of cross-linking between Ca 2+ and SA [ 41 ], which reflected that the higher the SA concentration, the denser is the shell structure. Thus, it may be inferred that the design of gel microspheres with different mechanical properties and physical properties can be achieved by varying the number of layers.…”

Section: Resultsmentioning

confidence: 99%

The Layered Encapsulation of Vitamin B2 and β-Carotene in Multilayer Alginate/Chitosan Gel Microspheres: Improving the Bioaccessibility of Vitamin B2 and β-Carotene

Liao

Dai

Lian

et al. 2021

Foods

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This research underlines the potential of alginate multilayered gel microspheres for the layered encapsulation and the simultaneous delivery of vitamin B2 (VB) and β-carotene (BC). Chitosan was used to improve the stability and controlled release ability of alginate-based gel microspheres. It was shown that a clear multilayered structure possessed the characteristics of pH response, and excellent thermal stability. The sodium alginate concentration and the number of layers had notable effects on mechanical properties and particle size of gel microspheres. Fourier-transform infrared spectroscopy and X-ray diffraction analyses further proved that VB and BC were encapsulated within the gel microspheres. Compared with the three-layer VB-loaded gel microspheres, the total release of VB from the three-layer VB and BC-loaded gel decreased from 93.23 to 85.58%. The total release of BC from the three-layer VB and BC-loaded gel increased from 66.11 to 69.24% compared with three-layer BC-loaded gel. The simultaneous encapsulation of VB and BC in multilayered gel microspheres can markedly improve their bioaccessibility and bioavailability. These results showed the multilayer gel microspheres synthesized herein have potential for applications in the layered encapsulation and simultaneous delivery of various bioactive substances to the intestinal tract.

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Oxidative stability of linseed oil nano-emulsions filled in calcium alginate hydrogels

Cited by 26 publications

References 59 publications

Antimicrobial and Anti-Inflammatory Activity of Low-Energy Assisted Nanohydrogel of Azadirachta indica Oil

Antimicrobial and Anti-Inflammatory Activity of Low-Energy Assisted Nanohydrogel of Azadirachta indica Oil

Sequence-Selected C₁₃-Dipeptide Self-Assembled Hydrogels for Encapsulation of Lemon Essential Oil with Antibacterial Activity

The Layered Encapsulation of Vitamin B2 and β-Carotene in Multilayer Alginate/Chitosan Gel Microspheres: Improving the Bioaccessibility of Vitamin B2 and β-Carotene

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Oxidative stability of linseed oil nano-emulsions filled in calcium alginate hydrogels

Cited by 26 publications

References 59 publications

Antimicrobial and Anti-Inflammatory Activity of Low-Energy Assisted Nanohydrogel of Azadirachta indica Oil

Antimicrobial and Anti-Inflammatory Activity of Low-Energy Assisted Nanohydrogel of Azadirachta indica Oil

Sequence-Selected C13-Dipeptide Self-Assembled Hydrogels for Encapsulation of Lemon Essential Oil with Antibacterial Activity

The Layered Encapsulation of Vitamin B2 and β-Carotene in Multilayer Alginate/Chitosan Gel Microspheres: Improving the Bioaccessibility of Vitamin B2 and β-Carotene

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Product

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Sequence-Selected C₁₃-Dipeptide Self-Assembled Hydrogels for Encapsulation of Lemon Essential Oil with Antibacterial Activity