Oxidative Status and DNA Damage Following Analgesic Treatment in Patients with Acute Pancreatitis

Gülen, Bedia; Kocyigit, A.; Eken, Cenker; Serinken, Mustafa; Karcıoğlu, Özgür; Dur, Ali; Kılıç, Emre

doi:10.7754/clin.lab.2015.151203

Cited by 2 publications

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“…moderate to strong traumatic musculoskeletal pain (Pagliara et al, ). Tramadol is an effective agent in the management of pain in acute pancreatitis, however, no significant difference in efficacy was found between NSAIDs (paracetamol, dexketoprofen) and tramadol in terms of pain control, (Gülen et al, ) oxidative stress and DNA damage parameters in AP settings (Gulen et al, ). Opioids are reported to decrease the need of supplementary analgesia ( n = 162, 3 studies) in acute pancreatitis highlighting their efficacy (Basurto Ona et al, ).…”

Section: Discussionmentioning

confidence: 99%

Comparison of efficacy of diclofenac and tramadol in relieving pain in patients of acute pancreatitis: A randomized parallel group double blind active controlled pilot study

Kumar

Muktesh

Samra

et al. 2019

European Journal of Pain

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Background Opioids and non steroidal anti inflammatory drugs (NSAIDs) are commonly used for pain relief in acute pancreatitis (AP). Opioids carry risk of sphincter of oddi constriction. Although diclofenac prevents post endoscopic retrograde cholangio‐pancreatography (ERCP) pancreatitis, few reports of diclofenac associated AP are also present. Although, both tramadol and diclofenac are commonly used for pain relief in AP, no study has evaluated their comparative efficacy and safety. Materials and Methods Forty‐six eligible participants were randomized to either diclofenac or tramadol. Primary objectives of our study were improvement in pain intensity on visual analogue scale (VAS pain score after 1 hr of drug administration) and number of patients requiring supplementary analgesia. The secondary objectives were total number of times of supplementary analgesia requirement, time to significant decrease (33%) in VAS pain score from baseline, number of painful days (VAS pain score >5), VAS pain score on 7th day, side effects, all cause death and complications of pancreatitis between the two groups. Results Although 46 patients were randomized, the final analysis included 41 participants. Five patients were withdrawn from the study (intubation = 3, altered sensorium = 2). No significant difference was seen in terms of VAS score after 1 hr of drug administration, number of patients requiring supplementary analgesic and number of painful days. However, time taken to significant reduction of pain was lower in the diclofenac group (p = .028). Both the agents were comparable in terms of safety. Although complications were less in the diclofenac group, the difference was not statistically significant. Conclusion Both diclofenac and tramadol are equally effective in controlling pain in AP with similar safety profile. Significance There are no studies that have compared the safety and efficacy of two commonly used analgesics for pain relief in patients with AP. We found that both diclofenac and tramadol are equally effective in decreasing the pain associated with AP. There is also no significant difference in the incidence of side effects between both the groups. Hence both diclofenac and tramadol can be used safely and effectively for pain control in AP. Trial registration: The trial was registered with clinical trials registry India (Number‐ CTRI/2018/05/014309).

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Section: Discussionmentioning

confidence: 99%

Comparison of efficacy of diclofenac and tramadol in relieving pain in patients of acute pancreatitis: A randomized parallel group double blind active controlled pilot study

Kumar

Muktesh

Samra

et al. 2019

European Journal of Pain

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show abstract

“…In the present study, a statistically significant increase was observed in the DNA DI of patients with D CML relative to the control group. The causes of DNA damage are multifactorial, and oxidative damage to this molecule has been attributed to drug therapy in other diseases [Gulen et al, 2016;Chen et al, 2017].…”

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confidence: 99%

Genotoxicity associated with the use of tyrosine kinase inhibitors in patients with chronic myeloid leukemia

Filho

Moreina-Nunes

et al. 2017

Environ and Mol Mutagen

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Oxidative Status and DNA Damage Following Analgesic Treatment in Patients with Acute Pancreatitis

Abstract: There is no difference between the effects of paracetamol, dexketoprofen, and tramadol, which are commonly used to manage acute pain in AP, on DNA damage in human T-lymphocytes and on serine parameters of oxidative status.

Cited by 2 publications

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Comparison of efficacy of diclofenac and tramadol in relieving pain in patients of acute pancreatitis: A randomized parallel group double blind active controlled pilot study

Comparison of efficacy of diclofenac and tramadol in relieving pain in patients of acute pancreatitis: A randomized parallel group double blind active controlled pilot study

Genotoxicity associated with the use of tyrosine kinase inhibitors in patients with chronic myeloid leukemia

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